Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Microbiota-gut-brain axis"”.
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Modulation of the microbiota-gut-brain axis by fermented foods
The gut harbours trillions of microbes that are involved in robust communication with the host. Various intrinsic and extrinsic factors modulate the composition of the gut microbiota. Over the past two decades seminal work on the impact of diet in shaping gut microbiota composition has resulted in …
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Unravelling the impact of pesticides on the microbiota-gut-brain axis
The gut microbiota exists within a dynamic ecosystem influenced by various factors, including exposure to xenobiotics such as pesticides. There is an increasing emphasis on the role of the gut microbiota in maintaining host health, including growing evidence for its role in regulating brain …
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The Microbiota Gut Brain Axis in the Neuropsychological Complications of Chemotherapy Treatment
… causes both neuroinflammatory changes within the brain, a neuropathological hallmark shared by all neuropsychological symptoms, and significant compositional changes to the gut microbiota. However, the role of the microbiota-gut-brain axis in the development of neuropsychological complications …
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Unravelling the impact of early-life nutrition on microbiota-gut-brain axis signalling
… childhood, are essential for optimal growth, brain and immune system function. Growing lines of evidence suggest that gut microbiota play a role in immune system education, brain function and behaviour. Disruptions in the gut microbiota composition during critical periods of development …
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Nutritional psychiatry, stress and the microbiota-gut-brain axis: focus on dietary fiber
… has an assortment of health benefits and the gut microbiota has been shown to be an integral regulator of brain function and behavior. The interface between these features may have implications from a therapeutic as well as a neurobiological perspective in terms of mental health function, …
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Decoding the interplay between the microbiota-gut-brain axis and the hypothalamic regulation of eating behaviour
… perspective we postulate a key role for the gut microbiota and its metabolites in the “priming” effects of this exposure. Increased food manipulation, or food crumbling behaviour was observed in a sex-specific manner (Chapter 2). The exposure to a HFHS diet during early-life had specific …
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Unravelling the role of tryptophan metabolism in the microbiota-gut-brain axis: focus on the effects of stress and exercise
The involvement of the microbiota-gut-brain axis communication in brain function and behaviour has enabled a paradigm shift in neuroscience, neurogastroenterology and psychiatric research. Two key routes of this bidirectional communication are impaired in stress-related disorders: the …
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Mining the microbiome for markers of microbiota-gut brain communication and mental health
… acknowledgement of the involvement of the gut microbiome - the collection of microbes that reside in our gut - in regulating our mood and behaviour. This phenomenon is referred to as the microbiota-gut-brain axis. While our techniques to measure the presence and abundance of these microbes …
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Exploring glucagon-like peptide 1-secreting L-cells as signal transducers in the microbiota-gut-brain signalling pathways
Background: Communication across the microbiota-gut-brain axis is integral to homeostatic functions throughout the body. However, the mechanisms behind this communication network have yet to be fully elucidated. There is mounting evidence that bacterially secreted metabolites, such as short-chain …
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The role of the gut microbiota in the function and integrity of brain barriers
The barriers of the brain help maintain an optimal environment for central nervous system (CNS) function and homeostasis. There are many instances such as during age related disorders and neuropsychiatric disorders in which these barriers are under threat. Importantly, the gut-microbiota can …
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Inflammasomes in the Intestinal Epithelium
… of this may underpin the diseases of the microbiota-gut-brain axis. Secondly, we have uncovered the importance of the non-canonical inflammasome and caspase-4 in producing intestinal IL-18. Through this we have discovered a novel mechanism of GSDMD and propose that GSDMD regulates the …
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The neurobiological effects of naturally-derived polyphenols and phospholipids in cellular & animal models of stress
… BDNF-dependent recovery, regulation of the HPA axis and the microbiota-gut-brain axis in polyphenol-mediated behavioural improvement. Taken together, our findings support the therapeutic potential of polyphenols for stress-related mental disorders, and we further provide evidence for the …
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Investigations on the role of the gut microbiota in hippocampal neuroplasticity and behaviour throughout the lifespan
… neuroplasticity within the hippocampus of the brain, as well as hippocampus-dependent behavioural processes. The hippocampus is one of the few brain regions in which new neurons are born throughout life, an ability that is critical for specific cognitive and emotional processes, making it …
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Examining the gut microbiota in aging
The human gut microbiome, comprised primarily of bacteria, plays a crucial role in overall health and physiology by regulating metabolism, immunity, and behavior through the microbiota-gut-brain axis (MGBA). Key functions include fermenting complex carbohydrates into short-chain fatty acids (SCFAs) …
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Neurobiological effects of food fermentation-derived metabolites for metabolic and mental health
… outside the gastrointestinal tract including the gut microbiome, the nervous system, immune system and hormonal system. Each of these play essential roles in the bi-directional communication pathway of the microbiota-gut-brain axis. Interactions between our food and this axis can potentially …
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The effects of nondigestible carbohydrates, prebiotics, and probiotics on gastrointestinal health and the microbiota-gutbrain axis in adults
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Peripheral alterations underlying the negative effects of a cafeteria diet on brain and behaviour: exercise as a mitigating strategy
… metabolic dysfunction, (neuro)inflammation, and gut microbiota alterations, which can result from a Western lifestyle, are associated with mood disorders and cognitive impairment, thus constituting potential mechanisms by which Western lifestyle impacts the brain. Adult hippocampal neurogenesis …
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Gut microbes and brain function
The gut-brain-microbiota axis comprises an extensive communication network between the brain, the gut, and the microbiota residing there. If the composition or the diversity of the gut microbiota is impaired, this can have negative consequences for host health and has been associated with disorders …