Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Microbiota-derived metabolites"”.
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TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS
… or tolerogenic activities depending on the microbiota, raising questions about their role in CAC development. To investigate this, high-dimensional single-cell cytometry, metagenomics, RNAseq, spatial immunophenotyping, transcriptomics, ex vivo and in vitro experiments were conducted. …
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Factors Governing Gastrointestinal Colonization of Candida albicans
… hosts. Depletion of specific gut commensal microbiota is associated with or results in increased C. albicans burden in the gut and increased likelihood of dissemination in human patients and mice, respectively. The exact mechanisms by which gut microbiota mediate C. albicans colonization …
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Microbial Metabolite Regulation of Microglial AHR Signaling in Alzheimer’s Disease
… that systemic factors, particularly the gut microbiota and its metabolites, play a significant role in shaping brain immune responses, including microglial activation. However, the mechanisms linking gut dysbiosis to microglial dysfunction in AD are poorly understood. The aryl hydrocarbon …
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Chemical Tools for Exploring Metabolite Interactions with Nuclear Receptors and Beyond
… development. The functionalization of native metabolites and synthetic small molecules with bio-orthogonal detection tags (alkyne, azide, and others) has afforded chemical reporters for the biochemical analysis of metabolically labelled proteins, whereas functionalization with …
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Insights into the molecular mechanisms of function and regulation of histone crotonylation
… the availability of the physiologically-relevant microbiota-derived short-chain fatty acids (SCFA). This makes it a candidate that links the microbiome and cellular metabolism to genome regulation. This link is particularly relevant in the gut, where cells of the epithelium are in direct contact …
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Decoding the interplay between the microbiota-gut-brain axis and the hypothalamic regulation of eating behaviour
… perspective we postulate a key role for the gut microbiota and its metabolites in the “priming” effects of this exposure. Increased food manipulation, or food crumbling behaviour was observed in a sex-specific manner (Chapter 2). The exposure to a HFHS diet during early-life had specific …