Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Microbiology in the Medical Area"”.
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Platelets and their immunomodulatory roles during Streptococcus pyogenes infection
Sepsis and invasive bacterial infection is a major cause of human disease and death worldwide. Streptococcus pyogenes is one of the major pathogens responsible for bacterial infections, which range from mild to severe and life threatening conditions. S. pyogenes contains a cell wall anchored M …
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Intrahost evolution of HIV-1 phenotypes
HIV-1 evolves constantly within an infected individual, due to its mutation-prone viral enzyme, high viral turnover and pressure from the host immune system. Therefore, viruses isolated at different time points from the same individual are never exactly the same and, accordingly, rarely function …
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Human papillomavirus testing and its application in cervical cancer prevention
SUMMARY Because of the strong causal relationship between persistent infections of human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for …
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Pseudovirions in the Study of Papilloma- and Polyomaviruses
The papilloma- and polyomaviruses are small DNA viruses that infect humans. Some members of these virus families can cause cancer in experimental animals and some are also established as carcinogenic to humans. Detection of specific antibodies to these viruses allows tracking past and present …
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Real-time PCR for diagnosis of botulism and quantification of neurotoxin gene expression in Clostridium botulinum
The objectives of the work presented in this thesis have been to develop molecular methods for (i) detection of Clostridium botulinum in food and clinical samples, and (ii) monitoring the expression of the neurotoxin gene, cnt, during different growth phases and under different growth conditions. …
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Human papillomaviruses in skin cancer and cervical cancer
The causal relationship between persistent genital infections with human papillomavirus (HPV) and development of cervical cancer is well established. In contrast, the significance of infections with cutaneous HPV for development of non-melanoma skin cancer (NMSC) is not well understood. We have …
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Structure and Function of HAMLET: Epitopes, Membrane Interactions and Molecular Recognition
HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded human alpha-lactalbumin and oleic acid that kills many different types of tumor cells and shows therapeutic efficacy in animal models and clinical studies. This thesis aims to (1) elucidate the structure …
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Determination and control of some pollutants in indoor environments
Unsatisfactory indoor air quality (IAQ) may result from polluting emissions that are spread from building materials such as volatile organic compounds (VOCs) and/or microbial components or from various kinds of human activity such as smoking. Different methods are available to limit the exposure to …
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Invasive disease by Haemophilus influenzae in Sweden in the era of the H. influenzae type b vaccine
What is the current status of Haemophilus influenzae as an agent of invasive infection in Sweden? H. influenzae type b (Hib) used to be a common cause of meningitis, epiglottitis and severe sepsis in young children. In the late 1980’s an effective conjugated vaccine against Hib was developed and a …
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Human papillomaviruses of skin and genital lesions
… (HPV) which has been established as the cause of cervical cancer and genital warts (condylomas). Cutaneous HPV types have been weakly associated with non-melanoma skin lesions such as squamous cell carcinoma (SCC) and actinic keratosis (AK). We have analyzed skin and genital lesions …
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Apoptosis of Peripheral Blood Leukocytes in Systemic Lupus Erythematosus: Studies on Serum Induction and Complement-Dependent Clearance Mechanisms
Systemic lupus erythematosus (SLE) is an autoimmune disease involving many organ systems. The cause is not known, but a complex combination of environmental and genetic factors seems to be involved. In SLE upregulation of type I interferons, a hyperactive B-cell response, presence of autoantibodies …
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"A syndrome so characteristic" Molecular and clinical studies of Fusobacterium necrophorum and Lemierre's syndrome
… is caused by Fusobacterium necrophorum and involves tonsillitis, jugular vein thrombophlebitis and septic pulmonary emboli. The first studies underlying this thesis focused on bacterial interaction with coagulation. The contact system initiates the intrinsic pathway of coagulation and the …
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The role of Moraxella catarrhalis outer membrane proteins in pathogenesis
… pathogen. It is a common cause of otitis media in children, a usual infections agent in sinusitis and makes up to 10% of all exacerbations of chronic obstructive pulmonary disease (COPD). It is known to cause more frequent disease in the colder season, and, generally, its importance is …
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FROM SERUM TO TISSUE: GALECTIN-BINDING GLYCOFORMS OF SERUM GLYCOPROTEINS AS FUNCTIONAL BIOMARKERS
Galectins are small soluble proteins defined by a conserved sequence motif that forms a defining β-galactoside binding site shared among galectins; adjacent binding sites give each galectin a unique fine specificity for a specific subset of galactose containing glycans. A wealth of data now …
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Diversity of Skin Infections
The identification of infectious agents in cancer has been one of the most rewarding endeavors in cancer research. Currently about 20% of the global cancer burden is linked to an infection. A common characteristic of virus-induced cancer is an increased incidence in immunosuppressed patients, …
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The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
Nontypeable Haemophilus influenzae (NTHi) is a remarkably proficient colonizer of the human respiratory tract. The aim of this thesis has been to characterize currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to …
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Human milk as a source of tumor killing molecules. From MAL to HAMLET.
HAMLET (Human alphalactalbumin made lethal to tumor cells), a complex between the partially unfolded alphalactalbumin and oleic acid, was discovered by serendipity when anti-adhesive properties of human milk were examined. HAMLET kills tumor cells but not healthy differentiated cells. Native …
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Haemophilus influenzae adhesins and the innate immune response
Haemophilus influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H. influenzae strains exist in six different serotypes a-f, of which type b (Hib) is the most virulent. Hib is protected by the polysaccharide capsule when invading the blood circulaton and may cause …
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Cutaneous Human Papillomaviruses
… (HPVs) exist as more than 100 distinct types. Variants of HPVs appear to be common findings while HPV subtypes have been considered rare. New information about subtypes has recently been reported by us. Our characterisation of subtype HPV38b[FA125] and the identification of several …
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Mycotoxins in indoor environments. Determination using mass spectrometry.
Dampness in indoor environments may cause various health problems. The specific causative agent(s) are unknown but may originate from degradation processes in damp materials, microbial growth, or a combination of these phenomena. The health impact of dampness in buildings is a politically, legally, …
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