Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Microbicides"”.
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Development of Advanced Delivery Systems for Microbicides
… for women, such as cervical barriers and microbicides. Microbicides are anti-infective medication formulated for topical self-administration before intercourse to protect against HIV and other sexually transmitted pathogens presents potential intervention strategy. Topical administration …
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Microbicides, sexuality and sexual health in KwaZulu-Natal, South Africa
… for women. Evidence supporting the benefit of microbicides in reducing the risk of vaginally acquired HIV acquisition has provided a major breakthrough. Despite the wealth of evidence supporting microbicide acceptability in Africa, there are still gaps in our understanding about how women will …
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Syntheses of Multi-headed, Two-tailed, Anionic Surfactants as Topical Microbicides
… anionic surfactants (3CAm1(n)2) as anti-HIV microbicides, and to compare the biological activities of these compounds to the activities of their straight-acyl chain derivatives. The synthesis requires coupling reaction of dialkylacetic acid (R2CHCOOH) (R2= n-C6H13, n-C7H15, n-C8H17, n-C9H19, …
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Dendronized Amphiphilic Copolymers Synthesized from Methacrylate Derivatives as Potential Topical Microbicides
… STDs and mucosal pathogens is urgent. Topical microbicides based on amphiphilic compounds have been identified as an attractive means toward this goal. Novel dendritic methacrylate macromonomers––di-tert-butyl 4-(2-tert-butoxycarbonyl-ethyl)-4-[3-(2-methacryoloxyethyl)ureido]heptandioate (MI) …
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HIV neutralization through use of antibodies and pharmacokinetics of topical applications
… effective approaches are being sought. Topical microbicides are being developed to provide a women-controlled method to prevent the transmission of HIV-1. Unfortunately, most of the candidate microbicide compounds tested to date have either elicited undesirable mucosal inflammation and …
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Targeted expression of the anti-HIV microbicide lectin griffithsin in maize and tobacco
… et al., 2000; Ma et al., 2003). Protein based microbicides,-namely, neutralising antibodies and peptide lectins- lend themselves to production in plants (De Muynck et al., 2010; Matoba et al., 2010; Sexton et al. 2006; O’Keefe et al., 2009). One of these lectins, namely Griffithsin (GRFT) was …
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Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
… delivery system loaded with anti-HIV topical microbicides for HIV prevention in women. In chapters 1 and 2, the overview of the problem, research objectives as well as the literature review of the technical and scientific background of this dissertation are introduced. In chapter 3, a study …
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MABGEL 1: C2F5, C4E10 & C2G12 as a vaginal microbicide
Topical microbicides are being developed as a female-controlled method for preventing HIV-1 infection. Non-antiretroviral (ARV)-based candidates may be advantageous given increasing levels of ARV resistance in low and middle- income countries.MABGEL 1 was a phase 1 trial designed to evaluate the …
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A gendered perspective of a community's perception of microbicide introduction
… approach. Respondents expressed keen support for microbicides, underscored by desperation related to the AIDS epidemic and recognition of women's greater risk. Discussions amongst both women and men around microbicide use revealed numerous ways in which a new preventive technology could impact on …
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Functional Characterization of the HIV-1 NEF Acidic Cluster
… new measures, including peptide inhibitors and microbicides, are currently being developed and studied for their efficacy. The potential of finding new targets for controlling or preventing infection relies heavily on developments relating to the basic science of the virus as well as the host …
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Mucosal HIV-1 Transmission in Humanized Mice
… candidate for pre-clinical evaluation of both microbicides and pre-exposure prophylactic regimens to prevent mucosal HIV-1 transmission.
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The role of surfaceant protein A in immunity to HPV16 pseudovirus infection
… may contribute to the development of topical microbicides incorporating recombinant fragments of SP-A to reduce the burden of new HPV infections.
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Characterisation of human surfactant protein A and recombinant human vimentin in their modulation of HPV16 pseudovirus infection
… into possible candidates for use in topical microbicides, which may provide protection against new HPV infections.
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IN VITRO SUSCEPTIBILITY OF CHLAMYDIA TRACHOMATIS TO LPS-BINDING POLYAMINES AND CELLULOSE ETHER POLYMERS: TOWARDS THE DEVELOPMENT OF A MICROBICIDE AGAINST CHLAMYDIA INFECTION
… of compounds for the two main components of microbicides; excipient and active ingredient. Excipient candidates were cellulose ether polymers, commonly used in vaginal gels and have pharmaceutical properties that favor their use in the preparation of controlled-release formulations for …
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… approach is the reformulation of topical vaginal microbicides. Our laboratory is developing HIV-targeted microbicide formulations that utilize highly specific, broadly neutralizing anti-HIV antibodies (bNAbs). The purpose of my research project was to characterize Fc receptor expression in …
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Derivatization of porphyrins for DNA and metal ion binding, especially by employing secondary sulfonamide links
… increasing attention is the development of microbicides which, when applied topically, can prevent viral infection. These compounds could directly interact with HIV virions to decrease or prevent infectivity, thus providing a defense against sexual transmission of the virus. Sulfonated …
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Mathematical and Experimental Analysis of Microbicide Vaginal Gels
HIV is a growing concern worldwide. With slow progress in the development of a vaccine, researchers have turned to alternate methods of preventing the spreading of HIV as a result of unprotected sexual intercourse. Developing a mechanism capable of protecting the vaginal or rectal epithelium from …
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Novel Biophotonic Imaging Techniques for Assessing Women's Reproductive Health
<p>Even though women make up over half the population in the United States, medical advancements in areas of women's health have typically lagged behind the rest of the medical field. Specifically, two major threats to women's reproductive health include human immunodeficiency virus (HIV), and …