Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Microbicide"”.
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Mathematical and Experimental Analysis of Microbicide Vaginal Gels
… One such tool can come in the form of a microbicide gel, which provides a physical barrier and acts as a delivery vehicle for its active ingredient. In order for the microbicide to be an effective barrier and delivery vehicle, it must have the capability to coat the epithelium for a …
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MABGEL 1: C2F5, C4E10 & C2G12 as a vaginal microbicide
Topical microbicides are being developed as a female-controlled method for preventing HIV-1 infection. Non-antiretroviral (ARV)-based candidates may be advantageous given increasing levels of ARV resistance in low and middle- income countries.MABGEL 1 was a phase 1 trial designed to evaluate the …
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A gendered perspective of a community's perception of microbicide introduction
… rather than their own. The development of a microbicide for HIV prevention may offer the possibility of reducing women’s risk of infection in situations where other more effective methods cannot be used. An environment conducive to introducing a microbicide is critical to avoid some of the …
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Targeted expression of the anti-HIV microbicide lectin griffithsin in maize and tobacco
… et al., 2000; Ma et al., 2003). Protein based microbicides,-namely, neutralising antibodies and peptide lectins- lend themselves to production in plants (De Muynck et al., 2010; Matoba et al., 2010; Sexton et al. 2006; O’Keefe et al., 2009). One of these lectins, namely Griffithsin (GRFT) was …
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Characterisation of HIV-1 Envelope features of breakthrough infections from the CAPRISA 004 Microbicide Trial
The CAPRISA 004 trial demonstrated the safety and a 39% efficacy of a 1% tenofovir (TFV) gel for the prevention of HIV-1 acquisition in young African women. It was subsequently shown that women assigned to the TFV arm who became infected had higher viral loads, slower anti-HIV-1 antibody avidity …
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Development and Evaluation Of HIV gp120 Responsive Microbicide Formulation for the Prevention of HIV Sexual Transmission
… urgent need to develop topical (vaginal/rectal) microbicide formulations capable of preventing HIV sexual transmission. The objective of this dissertation is to develop a mannose specific, lectin-based topical microbicide formulation capable of targeting HIV gp120 for the prevention of HIV sexual …
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IN VITRO SUSCEPTIBILITY OF CHLAMYDIA TRACHOMATIS TO LPS-BINDING POLYAMINES AND CELLULOSE ETHER POLYMERS: TOWARDS THE DEVELOPMENT OF A MICROBICIDE AGAINST CHLAMYDIA INFECTION
… on development of a vaginally-delivered topical microbicide as an alternative strategy for prevention of Chlamydia. The paucity of a well-established method suitable for large-scale analysis of in vitro Chlamydia infection is a major limitation in the development of novel anti-Chlamydia …
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The impact of sexually transmitted infections and inflammation in the female genital tract and blood on susceptibility to HIV-1 infection and disease progression
… even though they were using 1% tenofovir (TFV) microbicide. In the systemic compartment, the level of T cell activation and soluble markers of immune activation during HIV-1 infection are associated with disease outcome. Therefore, the relationships between plasma cytokine concentrations during …
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Microbicides, sexuality and sexual health in KwaZulu-Natal, South Africa
… for women. Evidence supporting the benefit of microbicides in reducing the risk of vaginally acquired HIV acquisition has provided a major breakthrough. Despite the wealth of evidence supporting microbicide acceptability in Africa, there are still gaps in our understanding about how women will …
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… approach is the reformulation of topical vaginal microbicides. Our laboratory is developing HIV-targeted microbicide formulations that utilize highly specific, broadly neutralizing anti-HIV antibodies (bNAbs). The purpose of my research project was to characterize Fc receptor expression in …
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Novel Biophotonic Imaging Techniques for Assessing Women's Reproductive Health
… interferometry (mLCI) to measure in vivo microbicide gel thickness distributions. The study explores the optical performance of the device and provides proof of concept measurements on a calibration socket, tissue phantom, and in vivo human data. Once the instrument is fully characterized, …
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Development of Advanced Delivery Systems for Microbicides
… for women, such as cervical barriers and microbicides. Microbicides are anti-infective medication formulated for topical self-administration before intercourse to protect against HIV and other sexually transmitted pathogens presents potential intervention strategy. Topical administration …
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Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention
… delivery system loaded with anti-HIV topical microbicides for HIV prevention in women. In chapters 1 and 2, the overview of the problem, research objectives as well as the literature review of the technical and scientific background of this dissertation are introduced. In chapter 3, a study …
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"If I could properly understand and get the right information...": The sexual and reproductive health needs and rights of women newly diagnosed with HIV: A qualitative study in the Western Cape Province South Africa
… seroconverted during the course of the larger microbicide, Carraguard study carried out by the Population Council and University of Cape Town. This study is novel in its exploration of these issues amongst women who are newly diagnosed and who were recruited outside of a health-care setting.
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Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors
… low cost, they may be considered for HIV-1 microbicide development. Anti-gp120 VHH might also prove useful in defining neutralising and non-neutralising epitopes on HIV-1 envelope proteins, with implications for HIV-1 vaccine design.
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Research on the epidemiology and prevention of HIV in rural south west Uganda, 1989-2010
… (of STDlbehaviour change and a phase 3 vaginal microbicide) are also discussed. Neither trial showed any effect on HIV transmission. To explain the findings from these trials, a conceptual framework for discussing negative results from HIV prevention trials has been used. The possible …
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Pig mucus as an inhibitory agent of HIV-1
… being a component of an anti-HIV-1 vaginal microbicide.
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Differential effects of combinations of anti-retrovirals and progestins on gene expression and HIV-1 replication in cells of the female genital tract
… who may consider the use of DPV as a microbicide. However, whether in vitro results will occur in vivo, remains to be established.
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Sterically Crowded Copolymers Based on Functionalized Stilbenes
… was found to be ~50 times higher than the microbicide, sodium poly(styrene sulfonate). The early study of antiviral activities of carboxylated stilbene and styrene polyanions also showed promising results. The synthesis of methyl sulfonate ester-functionalized polyanion precursors was …
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HIV neutralization through use of antibodies and pharmacokinetics of topical applications
… effective approaches are being sought. Topical microbicides are being developed to provide a women-controlled method to prevent the transmission of HIV-1. Unfortunately, most of the candidate microbicide compounds tested to date have either elicited undesirable mucosal inflammation and …
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