Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Microbial Physiology"”.
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Impacts of mucins on microbial physiology and interactions
… and urogenital tracts. Despite the enormous microbial population inhabiting the body, some of which are opportunistic pathogens, most people harbor these organisms without showing any signs of disease. The mucus that covers the wet epithelium and houses the microbiota is a prime candidate for …
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Mucins regulate virulence and colonization factors in Streptococcus pneumoniae
… have emerged as multifaceted regulators of microbial physiology and microbial communities. Defects in mucus production or changes in mucin glycosylation are associated with microbial dysbiosis, where the outgrowth of opportunistic pathogens threatens human health. Streptococcus pneumoniae is …
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Analyzing the Role of Mucin O-Glycans in Regulating Microbial Virulence
… component of mucus, are associated with microbial dysbiosis and infection; however, owing to the complexity of mucins, an understanding of the molecular motifs and mechanisms underlying mucins’ protective functions remains poorly understood. In this thesis, I fill this gap by …
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Linking microbial metabolism and organic matter cycling through metabolite distributions in the ocean
… not been well characterized and their roles in microbial physiology, ecological interactions, and carbon cycling remain largely unknown. In this dissertation metabolomics techniques were developed and used to profile and quantify a suite of metabolites in the field and in laboratory experiments. …
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Ecology of Culturable Organisms at Rozel Point, Great Salt Lake, Utah
… research, as it is essential for understanding microbial physiology. We report here the culturing and characterization of isolates from Rozel Point, located on the northeastern shore of Great Salt Lake. This site was chosen because of the presence of petroleum seeps at Rozel Point and the …
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Linking microbial metabolism and organic matter cycling through metabolite distributions in the ocean
… not been well characterized and their roles in microbial physiology, ecological interactions, and carbon cycling remain largely unknown. In this dissertation metabolomics techniques were developed and used to profile and quantify a suite of metabolites in the field and in laboratory experiments. …
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Optimising the Wider Energy Metabolome of Microbes Using Targeted UHPLC-MS/MS Present in Bio-Electrochemical Systems for Carbon Dioxide Conversion to Platform Chemicals
This thesis addresses a major analytical gap in microbial biotechnology by developing and validating a rapid, sensitive UHPLC-MS/MS platform for simultaneous quantification of the key intracellular energy metabolites that govern redox balance, energy charge, and carbon flux in industrial …
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Biomimetic membranes as new materials for applications in envrionmental engineering and biology
… in particular AqpZ and its possible role in microbial physiology. Finally, recent successes in immobilizing protein molecules and in synthesizing 2D crystals of membrane proteins may provide an excellent way to answer fundamental questions regarding the structure and function of these …
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The bi-directional relationship between gut microbiota and autoimmunity
<p>Humans serve as a major reservoir for a vast number of microbiota. These microbes have evolved symbiotic relationships with humans due to their close proximity with their host. As a result, the immune system adapts to the microbiota thus modulating immunological function. Autoimmunity is a state …
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Characterization of Helicobacter pylori sRNAs HPnc2525, HPnc2600, and HPnc2645
<p>Helicobacter pylori is a common microaerophilic gram-negative bacterium that infects approximately 50% of the human population. Although all H. pylori infections result in inflammation of the gastric epithelium, only 10-15% of infections are symptomatic and progress to severe gastric diseases …
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Integrated modeling of bacterial metabolism
… quantitatively understand and predict bacterial physiology and metabolism. In Chapter 2, I present an integrated modeling framework for acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum. ABE fermentation is a biphasic metabolic process during which cells convert carbon …
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Investigating proteins that influence membrane-associated germination processes in Bacillus subtilis spores
Many endospore-forming bacteria cause diseases such as anthrax and food poisoning. Spores however also contribute to various agricultural and industrial processes. Spores possess extreme resistance properties, notably to chemical, et and dry heat, desiccation, and UV damage. For pathogenic spore …
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Inhibition of <em>Escherichia coli</em> ATP Synthase Using Bioflavonoids.
<p>ATP synthase is the fundamental means of the cellular energy production in all organisms. Malfunction of ATP synthase is associated with multiple disease conditions. This enzyme is not only implicated in disease conditions but also likely to contribute in new therapies for multiple diseases by …
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Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
… hydrogen. Hydrogen provides an energy source for microbial metabolism and in combination with mineral catalysts can lead to the abiogenic synthesis of small organic compounds, such as methane. Serpentinite habitats contain abundant potential electron donors, but microorganisms presumably have …
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Conformational Rearrangements In The Sensory Rcsf/Omp Complex Mediate Signal Transduction Across The Bacterial Cell Envelope
<p>Timely detection and repair of envelope damage are paramount for bacterial survival. The Regulator of Capsule Synthesis (Rcs) stress response is a complex signaling cascade that monitors gram-negative cell envelope integrity and can transduce the stress signals across the multilayered envelope …
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Transposon Mutagenesis Facilitates Discovery Of Genotype-Phenotype Associations and Functional Interrogation of the <i>Mycobacterium Kansasii</i> Genome
… of <em>Mk</em> pathogenicity and efficacy of antimicrobial compounds. Finally, we combined Tn mutagenesis with next generation sequencing to identify 12,071 unique insertion sites that do not impact <em>Mk</em> viability. A comparison of our results to published transposon sequencing data for …
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Long-Chain Fatty Acids Promote Candida albicans Gut Colonization by Restructuring the Fungal Cell Surface
<p><strong>Long-chain fatty acids promote <em>Candida albicans</em> gut colonization by restructuring the fungal cell surface </strong></p> <p>Musfirat Shubaita, BS</p> <p>Advisory Professor: J. Christian Perez, Ph.D.</p> <p>The yeast <em>Candida albicans</em> is a facultative anaerobe residing in …
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The Effect of Cellular Dehydration on Glucose Regulation in Lean and Obese Females
<p>A chronically elevated vasopressin level has been associated with an impaired glucose regulation system in humans. A recent study in patients with diabetes suggested that low water intake is associated with impaired glucose regulation. The aim of this study was to examine the effect of …
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Characterizing The Regulation of Candida Albicans Hyphal Morphogenesis In The Context of Host Macrophages
<p><em>Candida albicans</em> is a commensal fungus that resides on the skin, mucosal surfaces, and in the gut of an estimated 80% of individuals. Though generally harmless, <em>C. albicans</em> is capable of causing uncomfortable mucosal infections as well as deadly disseminated infections …
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Requirement of ßDELSEED-Motif of <em>Escherichia coli</em> F<sub>1</sub>F<sub>O</sub> ATP Synthase in Antimicrobial Peptide Binding.
<p>F<sub>1</sub>F<sub>O</sub> ATP synthase is a membrane bound enzyme capable of synthesizing and hydrolyzing ATP. Lately, α-helical cationic peptides such as melittin and melittin related peptide (MRP) were shown to inhibit <em>E. coli</em> ATP synthase. The proposed but unconfirmed site of …
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