Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Microbial Metabolite"”.
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Microbial Metabolite Regulation of Microglial AHR Signaling in Alzheimer’s Disease
… factors, particularly the gut microbiota and its metabolites, play a significant role in shaping brain immune responses, including microglial activation. However, the mechanisms linking gut dysbiosis to microglial dysfunction in AD are poorly understood. The aryl hydrocarbon receptor (AHR), a …
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The gut-brain axis in seizure susceptibility: A role for microbial metabolite S-equol
… interactions, and through production of microbial-metabolites including neurotransmitters, short chain fatty acids (SCFAs), lactate, vitamins, and S-equol. Furthermore, the gut microbiota is crucial for neurodevelopment, indicating that the gut-brain axis may be involved in pediatric …
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Modulation of the microbiota-gut-brain axis by fermented foods
… foods or beverages produced through controlled microbial growth, and the conversion of food components through enzymatic action. Fermented foods can serve as conduits for potentially beneficial microbes, microbial metabolites and bioactives that can serve in a functional role to confer …
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Linking microbial metabolism and organic matter cycling through metabolite distributions in the ocean
… not been well characterized and their roles in microbial physiology, ecological interactions, and carbon cycling remain largely unknown. In this dissertation metabolomics techniques were developed and used to profile and quantify a suite of metabolites in the field and in laboratory experiments. …
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Linking microbial metabolism and organic matter cycling through metabolite distributions in the ocean
… not been well characterized and their roles in microbial physiology, ecological interactions, and carbon cycling remain largely unknown. In this dissertation metabolomics techniques were developed and used to profile and quantify a suite of metabolites in the field and in laboratory experiments. …
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High-Throughput Discovery of Stimuli of Bacterial Two-Component Systems from the Human Gut Microbiome
… virulence regulator PhoPQ, which recognizes antimicrobial peptides (AMPs) during Salmonella infection. Here, we identify altered sensitivity to surface-displayed AMPs in E. coli PhoPQ compared to Salmonella Typhimurium PhoPQ. In unpublished work, the Tabor lab has computationally identified over …
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Role of exercise-sensitive microbial-derived aromatic amino acid metabolites in modifying monocyte physiology
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Gut microbes and brain function
… screening gut-derived lactobacilli for bioactive metabolite production, namely GABA and serotonin, identifying one Lactobacillus plantarum GABA producer and two Lactobacillus paracasei serotonin producers which were subsequently characterised and assessed for probiotic characteristics. Enhanced …
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The role of the gut microbiota in the function and integrity of brain barriers
… between germ-free and conventional mice. Since microbial metabolites are some of the known contributing factors of the gut microbiota’s manipulation of the barriers, we next investigated the effects of physiological concentrations of short chain fatty acids (SCFAs), butyrate and propionate, with …
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Reducing the risk of prostate cancer with tomato and soy bioactives
… PCa by soy consumption is the production of the microbial-metabolite, equol, from daidzein. A TRAMP study from our lab suggested that a 2% soy germ diet reduced PCa incidence by 34%. The same study observed that prostatic equol concentrations were 39 times greater than prostatic genistein and 3 …