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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Microarray Experiment"”.
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Topics on statistical design and analysis of cDNA microarray experiment
A microarray is a powerful tool for surveying the expression levels of many thousands of genes simultaneously. It belongs to the new genomics technologies which have important applications in the biological, agricultural and pharmaceutical sciences. In this thesis, we focus on the dual channel cDNA …
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Molecular characterization of the Arabidopsis thaliana - Botrytis cinerea interaction
… after infection by Botrytis cinerea, using microarrays. The first microarray experiment focused on profiling Arabidopsis genes induced by B. cinerea over time (temporal) while the second investigated spatial expression of Arabidopsis genes from the point of inoculation. A number of genes …
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Genomic studies of social evolution in bees
… 4, I combine a behavioral analysis with a microarray experiment to explore how changes in maternal traits in queens of the bumble bee Bombus terrestris are regulated by workers during the nest initiation phase of the Bombus life cycle. Here, I provide evidence that workers socially regulate …
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The role of the cytochrome B and cytochrome C oxidase III genes in the immune response of the South African abalone, Haliotis midae
… III, were found to be upregulated in a cDNA microarray experiment performed on haemocytes from immunestimulated abalone (Arendze-Bailey, unpublished). The current study sought to confirm these results by semi-quantitative PCR and to further elucidate the roles of these genes, and thus the …
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The Effect of Low Temperature on Alternative Splicing in Barley
… cold-induced expression changes using available microarray and RNA-Seq data. The HvRS41 gene showed a >2 fold increase in expression after 3h exposure to 6°C in a cold-based microarray experiment. A cold-based microarray experiment in Arabidopsis showed a similar cold-induced expression of the …
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Investigating the effect of paralogs on microarray gene-set analysis
In order to interpret the results obtained from a microarray experiment, researchers often shift focus from analysis of individual differentially expressed genes to analyses of sets of genes. These gene-set analysis (GSA) methods use previously accumulated biological knowledge from databases such …
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Incorporation of Physico-Chemical Parameters Into Design of Microarray Experiments
Microarrays containing long oligonucleotides provide sensitive and specific detection of gene expression and are becoming a popular experimental platform. In the process of designing an oligonucleotide microarray for Brucella, we optimized the overall design of the array and created probes to …
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Diabetes Research Vortex : a novel information management system for Type I diabetes
… system for diabetes related publications and experimental data. The DRV was inspired by current T1D research paradigms. A user can choose to upload a publication or experimental data under one of four research categories: a strain, gene, Idd (Insulin Dependent Diabetic) genetic region, or …
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Molecular genetics of abdominal aortic aneurysm
… to the Human Genome (HG) -U133 plus 2.0 microarray (Affymetrix) that interrogates the whole human genome. The robustness of the genearray was assessed using data output quality control as defined by Affymetrix. Statistical analysis was then carried out using the GeneSpring software. Genes …
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Extracytoplasmic stress response systems in S. Typhimurium
… characterisation and regulation studies. A microarray experiment was designed in collaboration with colleagues at the Sanger Centre to identify members of the S. Typhimurium CpxAR regulon, with several members of this regulon being characterised further. The structural components of HtrA, an …
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Distributional aspects of P-value and their use in multiple testing situations
"High dimensional experiments (HDEs) involving thousands of simultaneous hypothesis tests have become more prevalent in recent years. Several statistical methods that have been proposed for analyzing data from such experiments have used the distribution of P-values that result from these tests. …
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Analysis of the Allergenic Potential of the Ubiquitous Airborne Fungus Alternaria Using Bioinformatics
… for the first time results of several sets of experiments including, 1) the analysis of A. alternata spore germination expressed sequence tags (ESTs), 2) the survey of global allergen homologues in fungal genomes, and 3) the first microarray experiment investigating airway epithelial cell …
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High-dimensional classification and attribute-based forecasting
… on high-dimensional classification problems in microarray experiments. The second part deals with forecasting problems with a large number of categories in predictors. Classification problems in microarray experiments refer to discriminating subjects with different biologic phenotypes or known …
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Linking transcript, QTL and association mapping to understand the genetic control of leaf size and shape in Populus
… from Quantitative Trait Loci (QTL), from a microarray experiment and from bioinformatics and literature searches, identifying sixty robust genes. From this list eight candidate genes were selected for further analysis; ASYMMETRIC LEAVES 1 (AS1), ASYMMETRIC LEAVES 2 (AS2), ACC OXIDASE ( ACO), …
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New statistical methods in bioinformatics: for the analysis of quantitative trait loci (QTL), microarrays, and eQTLs
… genes in an unreplicated multiple-treatment microarray timecourse experiment. In a two-sample setting, differential expression is well defined as non-equal means, but in the present setting, there are numerous expression patterns that may qualify as differential expression, and that may be of …
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Optimal Design of Single Factor cDNA Microarray experiments and Mixed Models for Gene Expression Data
Microarray experiments are used to perform gene expression profiling on a large scale. E- and A-optimality of mixed designs was established for experiments with up to 26 different varieties and with the restriction that the number of arrays available is equal to the number of varieties. Because the …
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Dexamethasone- and age-sensitive genes in neonatal small intestine
… et al., with fructose and then compared by microarray analysis. From this, a gene clustering analysis revealed that some age- and fructose-specific genes are regulated by corticosterones, which normally increase in pups >= 14 d old. Subsequent work indicated that priming the gut with …
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Transkriptomanalyse der <i>Arabidopsis</i>-Wurzel nach Infektion mit dem pilzlichen Pathogen <i>Verticillium longisporum</i> und Identifizierung von transkriptionellen Regulatoren der Pathogenantwort
… Reaktion von A. thaliana-Wurzeln.In einem Microarray-Experiment wurden Transkripte bestimmt, die in Wurzeln einen und drei Tage nach Verticillium-Infektion differentiell exprimiert sind. Die Transkriptomanalyse zeigte, dass die Infektion eine massive transkriptionelle Reprogrammierung …
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EMMA2 : a MAGE-compliant system for the analysis of microarray data in integrated functional genomics
… to study gene-expression and metabolic pathways. Microarrays have become a highly popular method to measure the transcriptional regulation in functional genomics. Microarrays allow to measure the expression levels of thousands of genes in parallel, but the measured datasets contain a certain level …
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Investigating molecular mechanisms of neuronal regeneration: a microarray approach.
… neurons do not normally regenerate. We used a microarray approach to identify putative regeneration-associated changes in gene expression in the L4 dorsal root ganglion (DRG) in rat models of PNS and CNS injury. Our models included crush injury to both branches of the bifurcating axon of …
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