Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"MicroRNAs (miRNA)"”.
-
High intensity exercise induced regulation of the microRNA biogenesis pathway
… reticulum. Recent studies suggest that microRNAs (miRNA) – small noncoding RNA molecules that fine-tune gene expression by silencing mRNAs through translational repression and/or transcript destabilization – dynamically respond to exercise and regulate the expression of genes involved in …
-
Integrative Analysis of the Myc and E2F pathway Reveal the Roles for microRNAs in Cell Fate Control
… a cancer cell, as well as expanding roles for microRNAs(miRNA) in control of gene expression, we asked if we may better understand the underlying regulatory (transcription factor, microRNA) structure that contribute to Myc and E2F pathway activities. Through integrative analysis of mRNA and …
-
Luminescence-Based MicroRNA Detection Methods
MicroRNAs (miRNA) are short, 18-24 nucleotide long noncoding RNAs. These small RNAs, which are initially transcribed in the nucleus, are transported into the cell cytoplasm where they regulate protein translation either through direct cleavage of mRNA, or indirect inhibition through binding to mRNA …
-
Functional analysis of the Argonaute family proteins during early embryonic and germ cell development in the mouse
… small non-coding RNAs. Specifically in mammals, microRNAs (miRNA) and short interfering RNAs (siRNAs) bind to Ago-like subclade of the Argonaute family to regulate gene expression, while Piwi-interacting RNAs (piRNAs) associate with PIWI proteins to silence transposons in the germ line.<br/>In …
-
Analysis of Cellular Transcriptomic Changes Induced by Merkel Cell Polyomavirus miRNA
… the majority of MCC cases has been established. microRNAs (miRNA, miR) are a family of small non-coding RNAs which play a key role in post-transcriptional regulation of gene expression and are considered significant players in disease and development in many species. Whilst the focus of MCV …
-
The Cellular Mirna, Mir-190, is Upregulated in Type I Ebv Latency by Ebers and Modulates Cellular Mrnas involved in Cell Survival and Viral Reactivation
… through different programs in host cells. MicroRNAs (miRNA) are small, non-coding RNAs capable of post-transcriptionally regulating mRNA expression. A microarray comparison of EBV type I latency and type III latency infected cells yielded evidence of differential cellular microRNA …
-
MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
… short (~22 nt) genetic molecules called microRNAs (miRNA) that regulate gene expression by repressing messenger RNA (mRNA) have gained attention as robust regulators of keratinocyte biology and key players in psoriasis. A specific miRNA elevated in psoriasis, miR-184, modulates the …
-
ORGANIC ELECTRONIC TRANSISTORS AND MICROFLUIDICS FOR CANCER BIOMARKER SENSING
MicroRNAs (miRNA) are a class of biomarkers whose relevance in oncology is increasing enormously, especially for cancers with high degree of invasiveness such as glioblastoma and lung cancer. Detection of miRNA circulating in blood appears a potential strategy for early diagnosis and patient …
-
Aseptic loosening around total hip and knee arthroplasty is linked to plasma microRNA
… this topic is beyond the scope of this thesis. MicroRNAs (miRNA) are well known for their ability to regulate gene expression in humans. They are present in all tissues and can be readily detectable in the blood stream and other bodily fluids contained within exosomes. Their use as biomarkers …
-
miR-322/503 Cluster Drives Cardiac Differentiation by Inhibiting CUG-binding Protein 1
… in promoting heart regeneration after injury. MicroRNAs (miRNAs) involved in the process are particularly interesting due to their small profile and relatively shorter path to clinic. With Mesp1 as the marker, we used a Mesp1-Cre/Rosa-EYFP reporter system to track the earliest cardiac …
-
The contribution of repeat associated small RNAs to genetic variation, hybrid vigor and inbreeding depression in maize
… of these classes are impacted by hybridization. MicroRNAs (miRNA) are typically 21-nt and often regulate plant growth, but we found that hybridization does not significantly alter miRNA accumulation. One miRNA that does show genotypic variation is microRNA172 (miR172), and its activity is reduced …
-
Effects of weaning age and maternal nutrition on gene expression of longissimus muscle of beef steers
… was assessed, mainly focusing in non-coding microRNAs (miRNA) epigenetics control. Results showed that proadipogenic miRNAs were controlling metabolism of LM of NW-MPN steers between 78 and 187 days of age through activation of: a) miR-103 that inhibits CAV1 that destabilizes INSR increasing …
-
Genetic Predictors of Clinical Outcomes In Non-Small Cell Lung Cancer Patients
… approach focusing on two critical pathways - miRNA and inflammation pathways. MicroRNAs (miRNA) post-transcriptionally regulate around 30% of human genes. Polymorphisms within miRNA processing pathways and binding sites may influence patients’ prognosis through altered gene regulation. …
-
Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… apoptotic pathway in pancreatic cancer.</p> <p>MicroRNAs (miRNA) have been identified as attractive targets for therapeutic intervention. The functional significance of lost miRNAs have been reported in several human malignancies, including PanCa. Restitution of lost miRNA function can provide a …