Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"MicroRNA-21"”.
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microRNA-21 as a Pro-Fibrotic Mediator in Right Ventricular Failure
… the limited understanding of RV pathophysiology. microRNAs (miRs) are major post-transcriptional regulators and their altered expression has been implicated in several cardiovascular pathologies. We hypothesized that altered miR expression specific to the failing RV may underlie the molecular …
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Microrna 21 targets B Cell Lymphoma 2 (Bcl2) Mrna to increase beta cell apoptosis and exosomal Microrna 21 could serve as a biomarker of developing Type 1 Diabetes Mellitus
The role of beta cell miR-21 in Type 1 Diabetes (T1D) pathophysiology has been controversial. Here, we sought to define the context of beta cell miR-21 upregulation in T1D and the phenotype of beta cell miR-21 overexpression through target identification. Furthermore, we sought to identify whether …
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RESVERATROL INHIBITS PROSTATE CANCER GROWTH AND METASTASIS BY TARGETING AKT/MICRORNA-21 PATHWAY
… available for metastatic prostate cancer. MicroRNAs (miRNAs) are small (18~23 nucleotide long) non-coding RNAs that can influence gene expression by binding to the 3'-untranslated region of coding RNAs at the post-transcriptional level. Some miRNAs has been termed as oncomirs due to their …
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Insulin resistance in cancer cachexia and metabolic syndrome
… interrupting the insulin receptor signal chain. MicroRNAs, non-coding RNAs linked to protein expression regulation, nowadays recognized as active players in the generation of several inflammatory disorders such as cancer and type II diabetes are also of interest. Considering that in cancer …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… display an intrinsic increase in Th2 genes and microRNA-21 (miR-21) expression. MiR-21 is a novel Bcl6 gene target in T cells and ectopic expression of miR-21 directs Th2 differentiation in non-polarized T cells. MiR-21 is up-regulated in mouse models of airway inflammation and also in human …
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The role of DNA damage associated microRNAs in enhancing the chemotherapeutic responses in triple negative breast cancer (TNBC)
… and the modulation of Doxorubicin responses with microRNAs to elucidate novel strategies to kill TNBC cells.Characterizing the response of TNBC cells to a minimum DNA damage following an exposure to low-dose radiation demonstrated that a sublethal radiation dose has the potential to propagate an …
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Connective Tissue Growth Factor in Pancreatitis
… PSC was associated with enhanced expression of microRNA-21 (miR-21). A positive feedback loop between CTGF/CCN2 and miR-21 was identified that resulted in an enhancement of their respective expression as well as that of collagen 1a(I). Both miR-21 and CTGF/CCN2 mRNA were detected in nano-sized …