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Showing 1 to 20 of 74 for “"Michael Addition"”.
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Michael addition of amines to α-ß unsaturated esters
<p>"The rate of Michael addition of primary amines to acrylates under different initial conditions was investigated. An acceptable agreement between different mathematical rate expressions was observed. The maximum rate was obtained in protic and polar solvents. The maximum temperature that …
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Fabrication, analysis, application, and characterization of core-containing microparticles and hydrophilic microfluidic devices produced via the primary- and in situ tertiary-amine catalyzed Michael addition of multifunctional thiols to multifunctional acrylates
… polymerization using the primary amine-catalyzed addition of a trithiol to a triacrylate was realized and investigated. Various core materials were microencapsulated via this technique and introduced into appropriate systems to improve the desired characteristics of the given system. In a specific …
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Design, synthesis and evaluation of organocatalysts in 1,4-conjugate additions to nitroolefins and alkylidene malonates
… activity and selectivity in 1,4-conjugate additions involving the Michael acceptor, nitrostyrene, was evaluated. Thiourea catalysts based upon the cinchona alkaloid framework were found to exhibit excellent activity and enantioselectivity (up to 95% yield and 97% ee) at loadings of 10 mol% …
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Preparation of Dehydropeptides and Their Application in the Convergent Synthesis of Peptide Conjugates
… dehydropeptide (the electrophilic handle) by Michael additions of suitable nucleophiles was developed. The C-terminal sequence of N-Ras, a number of other lipid peptides and S-linked glycopeptides were prepared through the Michael addition of corresponding thiolates to dehydropeptides. …
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NH-Isoxazolidines as Organocatalysts
… as catalysts in the Diels-Alder cycloaddition reaction, the Michael addition reaction and the Aldol condensation reaction is discussed. It has been demonstrated that the NH-isoxazolidines are effective in iminium ion catalysis and act as enantioselective organocatalysts for Diels-Alder …
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Determination of the relative stereochemistry of adducts resulting from the addition lithium dienolates to Michael acceptors
The addition of the lithium dienolate of ethyl crotonate to 2-cyclopentenone was studied to determine the stereochemical outcome of this Michael addition. Proof of the stereochemistry was provided via the unambiguous synthesis and comparison of ketone 73 from norcamphor 85.
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Alternatives to [4+1] carbocyclic annulations
… investigation of the course of intramolecular Michael addition-alkylation sequence of l-phenylsulfonyl-6-carboethoxyocta-5,7-dien-2-one.
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Organisch-anorganische Hybridmonomere, Makromonomere und Polyelektrolyte für Anwendungen in der Dentalchemie
… für Dentalmatrixharze und Nanokomposite war die Michael Addition von Aminen an Acrylate und Vinylphosphonate. Desweiteren wurden hyperverzweigte Polyelektrolyte auf ihre Eignung zur Herstellung von Glasionomerzementen untersucht. Neue acrylat- und methacrylatterminierte organisch-anorganische …
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The Use of Ipso-dihydrodiols Enzymatically Derived from Benzoic Acid in Enantioselective Synthesis. Appoaches to Total Synthesis of Vinca Alkaloids
… into Diels-Alder, radical cascade, and tandem Michael addition reactions as possible routes to the family of alkaloids. Also described are the chemoenzymatic syntheses of the natural product (-)-idesolide and unnatural polyhydroxylated pyrrolidines generated from the biotransformation of …
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Topology and Telechelic Functionality Control in Polyester Design
… displayed an enhanced cohesive strength. In addition, utilization of different comonomer compositions allowed tailoring thermal and adhesive properties of low-Tg polyesters over a wide range. Biodegradable networks were synthesized for the first time using base-catalyzed Michael addition of …
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Reductive Dehalogenation by Aqueous Biochars
… analysis coupled with chemical tagging through Michael addition reactions with cysteine identified possible QN-based compounds in a�"BCs and their formula. This study laid the foundation for the potential applications of the demonstrated reactions in the engineering treatment processes. Chemical …
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Amine Nucleophilic Addition to Nitro-alkene as a New Reaction Mode for the Synthesis of N-heterocycles
Amine Nucleophilic Addition to Nitro-alkene as a New Reaction Mode for the Synthesis of N-heterocycles: An efficient stereoselective synthesis of polycyclic lactams has been developed using Michael addition of conjugated amino-esters to nitro-alkenes. Using acyclic and cyclic aminoesters, this …
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Πορείες συνθέσεως ενώσεων με βιολογικό ενδιαφέρον από 2Η-πυραν-3(6Η)-όνες
… a) The chemistry of 2H-pyran-3(6H)-ones. b) 1,4-addition (Michael) to 2H-pyran-3(6H)-ones. c) Immunostimulants. d) Sympathomimetic amines, neurotransmitters. Part II contains five chapters and deals with the results of the present work. More specifically describes: i) The synthesis of …
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Mechanistic Investigations of Cyclase Enzymes Involved in Lantibiotic Biosynthesis
… termed lanthionines, putatively generated by Michael addition of cysteines to dehydrated serine and threonine residues in the pre-lantibiotic peptide. In class AI lantibiotics, the post-translational modifications are proposed to involve a multi-enzyme complex including the proteins LanB and …
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Synthesis and Non-Covalent Interactions of Novel Phosphonium-Containing Polymers
… monomers in the formation of networks from Michael addition reactions led to the synthesis of ionic networks with increased and broadened glass transitions and improved tensile stresses at break and strains at break compared to those in the non-ionic networks. The first electrospun fibers …
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Multi-component Reactions Initiated via Sonogashira Coupling
… internal alkynes that can now undergo a Michael addition with suitable secondary amines. This coupling-aminovinylation sequence can be performed in a one-pot fashion, providing a straightforward access to push-pull chromophores. By applying acid chlorides instead of arylbromides, it was …
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ΠΟΡΕΙΕΣ ΣΥΝΘΕΣΕΩΣ ΚΑΙ ΗΜΙΣΥΝΘΕΣΕΩΣ ΝΕΩΝ ΑΝΤΙΒΙΟΤΙΚΩΝ 'Η ΑΝΑΛΟΓΩΝ ΤΟΥΣ
… ANTILEUKEMIC ANTIBIOTIC VIA 2H-PYRAN-3(6H)-ONE. MICHAEL ADDITION OF BENZYLAMINE TO 2H-PYRAN-3(6H)-ONES. RESOLYTION OF RACEMIC D, L 2H-PYRAN-E(6H)-ONES SEVERAL 6-HYDROXY-2H-PYRAN-3(6H)-ONES WERE ESTERIFIED WITH BOC-ALA-OH IN LIGH YIELD. SYNTHESIS OF D AND L SUGARS. SYNTHESIS OF L AND D ACULOSE.
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Explorations with optically active, cage-annulated crown ethers.
… as chiral catalysts in an enantioselective Michael addition was studied. The extent of asymmetric induction, expressed in terms of the enantiomeric excess (%ee), was monitored by measuring the optical rotation of the product and comparing to the literature value.
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Extending Highthroughput Technologies: The Automation of Mechanism Discovery Investigations into the mode and action of the thio-Michael Reaction
… project concerns the investigation of the thio-Michael reaction (see scheme). The approach has employed a process development methodology to chemical discovery rather than more traditional research methods. Stage One involved the investigation of rates of addition with and without different …
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Chemical functionalization and modification of Au clusters
… amine-terminated Au NCs was investigated by the Michael addition reaction of the primary amines with methyl acrylate. Based on the UV-Vis spectra and Transmission Electron Microscopy (TEM) images, the size of the NCs remained unchanged during the synthesis and after the functionalization reaction …
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