Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Mice, Transgenic"”.
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NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
… and improve tumor rejection, we developed a transgenic model whereby the 5E6 Fab antibody fragments are constitutively secreted to allow the sustained blockade of the Ly49C/I receptor. These studies detail the generation of these Tg mice and their characterization in relation to NK and T cell …
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The prion-like properties of assembled human alpha-synuclein
… protein, aggregated alpha-synuclein from mice transgenic for A53T alpha-synuclein, as well as alpha-synuclein aggregates from Parkinson’s disease and multiple system atrophy brains, seeded aggregation. The mechanisms of alpha-synuclein internalization and intracellular trafficking, and how …
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Spatial-Temporal Regulation of the Atonal Homolog 1 Gene
… and the cochlear and vestibular hair cells of mice. The purpose of these studies was to determine how atonal homolog 1 is regulated by analyzing the activity of atonal homolog 1 regulatory regions. This was accomplished by deleting different conserved regions in a bacterial artificial …
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The Role of TNF Signaling in Regulating Beta-Amyloid Burden in the 3xTgAD Mouse Model of Alzheimer's Disease
… observed in the hippocampus and cortex of 3xTgAD mice (transgenic mouse expressing human familial AD mutations in APP, PS1, and a familial frontotemporal dementia mutation in tau) after chronic systemic LPS exposure, we inhibited TNF signaling with novel engineered dominant negative TNF inhibitors …
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Analysis of Circadian Rhythm Using a Novel SCN-Specific Cre Transgenic Mouse Line
… test this hypothesis, a novel SCN-specific Cre transgenic mouse line, named NMS-Cre, was developed by inserting a bicistronic Cre expression cassette at the 3’-untranslated region of the Neuromedin S (NMS) gene. By crossing NMS-Cre line to a lox-STOP-lox diphtheria toxin receptor line, …
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Constitutive Overexpression of Acyloxyacyl Hydrolase in Mus Musculus
… to the experiments described in this study, mice deficient in AOAH were found to be susceptible to the long-term effects of LPS. Aoah-/- mice developed long-lasting hepatomegaly, exaggerated antibody responses, and prolonged immunosuppression in response to small doses of LPS. In the studies …
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Neural Stem Cells in Brain Tumor Development
… Through somatic loss of heterozygosity, these mice develop varying grades of astrocytic malignancy with 100% penetrance. Studies on our tumor suppressor mouse models indicated a central role for neural stem cells and stem cell-like cancer cells in malignant astrocytoma formation. Using …
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Targeted Disruption of the Deaf1 Gene in Mouse Brain and the Effects on Behavior and Gene Expression
… and dorsal raphe nucleus. We hypothesized that mice with targeted deletion of <italic>Deaf1</italic> in brain would produce behavior phenotypes analogous to human MDD and ID, and that changes in <italic>Deaf1</italic>-target gene expression would be associated with behavior changes. To test this …
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Analysis of the role of the X/Y homologous gene family Xmr/Sly in murine spermiogenesis
… essential for normal sperm production in humans, mice and Drosophila. In mice, deletions of the Y chromosome long arm (Yq) are associated with abnormal sperm head formation, reduced fertilising ability, up-regulation of spermatid-expressed sex-linked genes, and an offspring sex ratio distortion in …
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Identification of gene expression changes in Drosophila models of mammalian prion diseases
… (PrPSc). Prion inoculated wild-type and PrP transgenic mice have been used to model acquired prion diseases. Mice transgenic for mutated forms of PrP have also been used to model different genetic prion diseases. Mouse models of different prion diseases have been used to investigate …
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Modeling Brk/PTK6 expression in the mammary epithelium.
… a WAP-driven Brk/PTK6 transgene in FVB/n mice, and analyzed wild type and transgenic mammary glands after forced weaning. Brk-transgenic dams exhibited delayed mammary gland involution and infrequent tumors in aged mice. Transgenic mammary glands displayed decreased STAT3 phosphorylation, …
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A NOVEL METHOD TO INTERFERE WITH GENE EXPRESSION IN MICE
Transgenic animals are generated by injection of recombinant DNA sequences into fertilized oocytes. Here I applied a new methodology for the generation of transgenic knockdown mice using the LentiLox 3.7 lentivirus as a transfer vehicle bearing an U6-promoter dependent shRNA expression cassette. …