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Showing 1 to 2 of 2 for “"MftC"”.
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Sensitivity of Radical SAM Enzyme MftC to Molecular Oxygen
<p>MftC is a radical S-adenosyl L-methionine (SAM) enzyme that catalyzes the first step in the production of mycofactocin. It is a ribosomally synthesized post-translationally modified (RiPP) redox cofactor shown to be essential for the survival of bacteria in the <em>Mycobacterium</em> genus in …
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New Insights into Mycofactocin Biosynthesis, Structure and Function
… of the RRE domain MftB, the RS-SPASM enzyme MftC, catalyzes the SAM-dependent oxidative decarboxylation and carbon-carbon bond formation on MftA to form MftA*. The roles of the auxiliary [Fe-S] clusters in MftC catalysis as well as the subsequent steps in the biosynthesis of mycofactocin are …