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Showing 1 to 20 of 65 for “"Metronidazole"”.
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Characterization of metronidazole resistant Helicobacter pylori
The high prevalence of metronidazole resistant Helicobacter pylori (MtzR- Hp ) in relation to gastroduodenal disease is of concern. The study shows that MtzR- Hp is significantly higher in non-ulcer dyspepsia patients ( p = 0.005), expresses lower Le b ( p = 0.0365) and babA2 ( p = 0.03). RAPD …
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Identification of Bacteroides genes involved in Metronidazole resistance
… of choice for treating such infections is metronidazole, a DNA damaging agent. Metronidazole enters the bacterial cell as an inert prodrug, and is activated by cellular reduction into a cytotoxic compound which is thought to cause DNA strand breaks. Certain metronidazole resistant B. …
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Elution of Metronidazole and Gentamicin from Polymethylmethacrylate Beads
… polymethylmethacrylate (PMMA) beads containing metronidazole (3 concentrations); gentamicin sulfate; or metronidazole and gentamicin sulfate were immersed in 5 ml of phosphate buffered saline in triplicate. Eluent was replaced at specified time intervals for 1 day (1, 3, 6, 12 and 24 hours), …
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Induction of metronidazole and clindamycin resistance in gardnerella vaginalis
… with G. vaginalis are typically treated with metronidazole or clindamycin. There has recently been an increase in recurrent BV infections and treatment failure. Antimicrobial resistance in bacteria has proven to lead to higher rates of adverse health outcomes. Understanding the susceptibility …
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Injectable in situ Gelling Metronidazole System for Treating Jawbone Infections
… with a prolonged course of antibiotic therapy. Metronidazole is effective against many gram-negative and gram-positive anaerobic bacteria commonly found in dental infections. However, its poor bioavailability in jawbone requires frequent administration of very high dose of metronidazole which …
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Nitric Oxide in the Cytotoxicity of Metronidazole Against Trichomonas Vaginalis
… for NO in EPR. Using Fe-MGD, the reduction of metronidazole in various systems was examined. When metronidazole was incubated for one hour at 37°C with (1) sodium dithionite and (2) the enzymatic mixture consisting of ferredoxin oxidoreductase, ferredoxin, and NADPH, NO was only detected by …
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The effect of metronidazole on Bacteroides fragilis and Escherichia coli
The antibiotic metronidazole is used extensively in the clinical treatment of anaerobic infections, including those caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole …
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Rhamnose metabolism and metronidazole resistance in B. thetaiotaomicron VPI-5482
… and other opportunistic pathogens to metronidazole, the leading drug of choice. This dissertation aimed to use physiological, molecular and biochemical analyses to elucidate the possible mechanism/s of metronidazole resistance in B. thetaiotaomicron, in order to extend the …
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Characterization of Metronidazole- and Vancomycin-Resistant Clinical Isolates of Clostridium Difficile
<p><strong>Characterization of Metronidazole- and Vancomycin-Resistant Clinical Isolates of <em>Clostridium difficile</em></strong></p> <p>Chioma Odo, MS.</p> <p>Supervisory Professor: Charles Darkoh, Ph.D.</p> <p><strong>ABSTRACT</strong></p> <p>The incidence of <em>C. difficile</em> infections …
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Characterization of a transposon-induced pleiotropic metronidazole resistant mutant of Clostridium acetobutylicum P262
Metronidazole is a pro-drug which must be reduced to elicit a bactericidal effect. In the clostridia, some of the electron transport proteins that provide the source of electrons for the reductive activation of metronidazole play a key role in electron distribution, which in turn regulates the …
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Effect of ethyl oleate and oleic anhydride on metronidazole release from poly(ortho esters) films
… with regard to the release characteristics of metronidazole (1 0% w/w) from poly( ortho esters) films in distilled water at 3 7 °C. The rate of release of metronidazole from poly(miho esters) films was dependent on the ethyl oleate or oleic anhydride concentrations. The poly(ortho esters) films …
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Metronidazole resistance in clinical Bacteroides fragilis isolates from Groote Schuur Hospital, Cape Town, South Africa
… to several of the antibiotics, specifically metronidazole, used in the clinical setting. The aim of this thesis was to examine the levels of antibiotic resistance of 23 B. fragilis strains isolated at Groote Schuur Hospital, Cape Town, and determine the metronidazole (Mtz) resistance …
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Evaluation of amoxicillin, metronidazole and gentamicin dosage regimens for use in antibiotic prophylaxis in colorectal surgery
… models were developed for amoxicillin, metronidazole, and gentamicin usingNONMEM® in order to determine the probability of maintaining free drugconcentrations above the MIC breakpoints of the following microorganisms:methicillin-sensitive Staphylococcus aureus, Escherichia coli, …
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Microarray analysis of Trichomonas vaginalis strains T1 and G3: Identifying genes that may contribute to virulence and metronidazole resistance
… is easily treated with a single dose of Metronidazole. Drug resistance is not common, but it is on the rise. In addition to increasing rates of drug resistance, Trichomoniasis also poses a public health threat as it has been shown to increase the risk of HIV transmission. In order to …
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Evaluation of Antibiotic Drug Synergisms Against Periodontal Aggregatibacter Actinomycetemcomitans
… synergisms between amoxicillin plus metronidazole, between ciprofloxacin plus metronidazole, and between spiramycin and metronidazole, against clinical periodontal isolates of A. actinomycetemcomitans of United States origin. Methods: Standardized cell suspensions, equivalent to a 1.0 …
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Studies on nucleotide levels and electron transport genes of Clostridium acetobutylicum P262
… increase in sporulation. The antibacterial agent metronidazole, was used as a tool for the isolation of C. acetobutylicum electron transport genes. Since it was desired to clone these genes in Escherichia coli, and investigation into the activation of metronidazole by E. coli strains was …
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A cluster of two serine transfer RNA genes from Clostridium acetobutylicum P262
A cloning system, using metronidazole as a screening tool and E. coli FI9 as a selection host, was previously established to clone C. acetobutylicum P262 electron transport genes which may play a role in solvent metabolism in this bacterium. In theory, metronidazole would be reduced under anaerobic …
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DNA repair in bacteroides fragilis
… approximately half of anaerobic bacteraemias. Metronidazole is used to treat anaerobic infections. It diffuses into the celI as an inactive prodrug where it is reduced to form nitro anion and nitroso and hydroxylamine radicals. These chemically reactive compounds interact with DNA causing …
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