Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Metoprolol"”.
-
CYP2D6 Inhibitory Activities of Sarpogrelate hydrochloride and Drug-Drug Interaction
… crossover study. A single oral dose of metoprolol (100 mg) was administered with water (treatment A) and sarpogrelate (100 mg bid.; a total dose of 200 mg; treatment B), or after pretreatment of sarpogrelate for 3 days (100 mg tid.; treatment C). Plasma levels of metoprolol and …
-
The validation of heart rate variability in individuals with spinal cord injury
… min continuous ECG recordings during rest, after Metoprolol administration (max dose=3x5mg) and after Atropine administration (0.02mg/kg) in both supine and 40° head-up tilt. After Metoprolol administration there was a 61.8% decrease in the LF:HF ratio in the SCI participants suggesting that the …
-
Development of a platform for nasal delivery of peptides and vaccines using powder carriers based on starch/poly(acrylic) acid
… mixture was co-spray-dried with metoprolol tartrate (used as model molecule) in order to develop a powder suitable for nasal drug delivery via a one-step manufacturing process. The bioavailability of metoprolol tartrate after nasal administration of this powder to rabbits was …
-
Meeting the challenges of quantifying the elimination processes of pharmaceuticals in rivers
… betrachteten Pharmaka (Bezafibrat, Diclofenac, Metoprolol, Naproxen) konnte keine Eliminierung nachgewiesen werden. Aufgrund der geringeren Austauschraten zwischen Oberflächenwasser und Sedimenten wurde die Eliminierung von Ibuprofen und Clofibrinsäure auf biologische Transformation in …
-
A thermal/thermo-mechanical and imaging study of component distribution and interaction in pharmaceutical film coats
… water, pH 1.2 and 6.8 buffers. Dissolution of metoprolol succinate and paracetamol from SureSpheres® pellets coated by these films were then carried out. OA and DBS were more efficient than MCT for EC films. OA and DBS showed good compatibility with EC, whereas at 20% plasticizer level and …
-
How does pulmonary exposure to particulate matter predispose the heart to increased injury after myocardial infarction?
… activation. The beta 1 (β1) selective blocker metoprolol was used to investigate the role of the sympathetic nervous system (SNS) in transmitting the influence of DEP in the lung to the myocardium via β1 adrenoceptor activation. Administration of metoprolol (10 mg/kg, intraperotineal) at the …
-
Ultrasound features of human carotid plaques
… different, more vulnerable, type. Treatment with metoprolol for 3 years decreased progression of intima-media thickness in the bulb. In a post hoc analysis, measuring echogenicity in ultrasound images of carotid plaques in subjects with and without metoprolol treatment, plaque in treated subjects …
-
Evidenz-basierte Pharmakotherapie der Herzinsuffizienz an der stationär-ambulanten Schnittstelle
… und Beta-Blocker mit erwiesenem Langzeiteffekt (Metoprolol, Bisoprolol, Carvedilol, 64,3% vs. 89.0%). Auch Aldosteronantagonisten wurden in der Klinik häufiger verabreicht als nach Entlassung (38,5% vs. 33,8%). Die Verordnung der Aldosteronantagonisten erfolgte sowohl in der Klinik, als auch bei …
-
A Rational Approach to the Design of Highly Effective Chiral Stationary Phases
… blocking agents, propranolol and metoprolol (3,5-dinitrobenzoyl derivative), central nervous system stimulant amphetamine (3,5-dinitrobenzoyl derivative) and antiinflammatory agent ibuprofen (3,5-dintiroanilide derivative) also resolved quite well on these chiral stationary phases.
-
Analysis of Neural Contributions to Ultradian Oscillations of Blood Pressure and Heart Rate in Dogs
… oscillations, and may actually attenuate them. Metoprolol (200mg/day; b.i.d. for 5 days), a beta$\sb1$ antagonist, significantly decreased the power of HR and MAP oscillations. Prazosin (50ug/kg/hr), an alpha$\sb1$ antagonist, significantly decreased the power of MAP oscillations but increased …
-
Cardiac Autonomic Assessment and Diastolic Function in Individuals with Spinal Cord Injury
… baseline after blocking sympathetic outflow via metoprolol. Moreover, while participants were resting, the QTVI increased after blocking parasympathetic activity via atropine. These results suggest that the QTVI may reflect both cardiac sympathetic and parasympathetic activity in those with …
-
Ocorrência e distribuição de fármacos, cafeína e bisfenol-a em alguns corpos hídricos no Estado do Rio de Janeiro
… diazepam, lorazepam, venlafaxina, atenolol, metoprolol, nadolol, propanolol, sotalol, furosemida, torasemida, glibenclamida, irbesartan, losartan, valsartan, warfarina, tiabendazol, xilazina, sulfametoxazol, trimetoprim), cafeína e bisfenol-a, empregando a técnica analítica de extração em …
-
Neuroendocrine mechanisms of behavioral changes induced by hypoglycemia
… of the adrenergic receptors with phentolamine, metoprolol and butoxamine, or treatment with the anti-depressants (fluoxetine and desipramine) ablated the insulin-induced saccharin aversion and increased immobility in forced swim test. Taken together, these data indicate that anhedonia and …
-
Developing novel therapeutic agents for Acanthamoeba infection and investigating the process of encystment
… stimulated the encystment and the antagonists β₁ metoprolol blocked the formation of cysts and protocysts. Two different herbicides including 2,6-dichlorobenzonitrile (DCB) and isoxaben were tested to target the biosynthesis of cellulose in the cyst form and also to evaluate their effects on the …
-
Novel In-Vitro Approaches to Investigate Membrane Partitioning and pH-Dependent Passive Permeation of Small Molecule Drugs
… rat hepatocyte suspensions for tolbutamide and metoprolol, respectively.
-
Liquid-core microcapsules: A mechanism for the recovery and purification of selected molecules in different environments
… active compounds; sulfamethoxazole, metoprolol, furosemide, carbamazepine, clofibric acid, warfarin and diclofenac from water. The approach of preparing capsules with different solvents within their cores and combining them in water, contaminated with pharmaceuticals, enabled a rapid …
-
Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model.
The studies in this thesis are based on questions raised in the clinical setting. Perioperative myocardial ischemia occurs more often than recognized. This may lead to myocardial infarction, increased morbidity, mortality, and health care costs. In the first study, myocardial metabolism was …