Global ETD Search
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Showing 1 to 3 of 3 for “"Methylthioadenosine phosphorylase"”.
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Therapeutic Potential of Prmt5 and Mat2A As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors
<p>Homozygous deletion of methylthioadenosine phosphorylase (<em>MTAP</em>) is a frequent genetic alteration found in approximately 15% of all human cancers, including glioblastoma, pancreatic cancer, mesothelioma, urothelial bladder carcinoma, and lung squamous cell carcinoma. MTAP is a critical …
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Targeting a Metabolic Vulnerability in Prostate Cancer
… rate-limiting enzyme involved in this process is methylthioadenosine phosphorylase (MTAP). De novo synthesis of methionine depends on the availability of folate, acquired from the diet, which acts as a carrier for one-carbon units through one-carbon metabolism. The one-carbon unit, donated from …
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Functional and Therapeutic Relevance of MTAP Deletion in Glioblastoma
… identified in GBM is homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene, which occurs in 50% of all GBM cases. Despite its common occurrence, it is unclear what contribution MTAP loss makes in the pathogenesis of GBM or whether this genetic alteration can be used as a …