Global ETD Search
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Showing 1 to 20 of 51 for “"Methylphenidate"”.
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Molecular and Neurochemical Effects of Methylphenidate on the Developing Brain
… observed in ADHD patients. The psychostimulant, methylphenidate (MPH) is the preferred drug for the treatment of the disorder, however the long-term consequences of the drug are not yet established. Here, we have investigated the effects of acute and chronic MPH treatment on monoaminergic protein …
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State Dependent Recognition With Methylphenidate and Thioridazine in Retarded Children
Made available in DSpace on 2014-12-10T21:07:01Z (GMT). No. of bitstreams: 1 7114777.pdf: 5090879 bytes, checksum: 60edf8ee8ad18c51c42ff89b18e122de (MD5) Previous issue date: 1970
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The influence of methylphenidate on heart rate and brain connectivity
… in examining the impact of a dopaminergic agent, methylphenidate (MPH) on: a) brain connectivity at rest before exercise and during exercise, b) on heart rate (HR) at rest before exercise and during exercise. Furthermore, c) I was interested in whether the effect of MPH administration (MA) on HR …
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UNIQUE PHARMACODYNAMIC PROFILE OF METHYLPHENIDATE: SELF-ADMINISTRATION-INDUCED DOPAMINE SYSTEM ALTERATIONS
Methylphenidate (MPH), the active compound in the medication Ritalin, is commonly diverted for off-label use. It is abused at high rates in both the adolescent and adult population; however, until recently, the neurochemical effects of MPH abuse had not been explored in depth. Pharmacologically MPH …
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Role of Dopamine of Nucleus Accumbens In Behavioral Sensitization to Methylphenidate
… sensitization elicited by chronic treatment with methylphenidate (MPD), a psychostimulant that is widely used to treat attention deficit hyperactivity disorder. The dopaminergic afferents can be selectively destroyed using catecholamine neurotoxin 6-hydroxydopamine (6-OHDA). In order to determine …
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Dosage Effects of Methylphenidate on the Activity Level of Hyperactive Children
Made available in DSpace on 2014-12-12T01:12:11Z (GMT). No. of bitstreams: 1 7212442.pdf: 4126874 bytes, checksum: 3fed8fbbc25f8755930c97733e2657ca (MD5) Previous issue date: 1971
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Behavioral Responses to Methylphenidate: Correlations With Neuronal Activity In The Caudate Nucleus
<p>Methylphenidate is currently a drug of abuse and readily prescribed to both adolescents and adults. Chronic methylphenidate (MPH) exposure results in an increase in DA in the motive circuit, including the caudate nucleus (CN), similar to other drugs of abuse. This study focuses on research aimed …
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EFFECTS OF METHYLPHENIDATE ON AUDITORY INTENSITY DISCRIMINATION AND GENERALIZATION IN THE IMMATURE RAT.
EFFECTS OF METHYLPHENIDATE ON AUDITORY INTENSITY DISCRIMINATION AND GENERALIZATION IN THE IMMATURE RAT.
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The Effects of Methylphenidate on Resource Allocation in the Mental Processing of ADD Children
<p>The effect of Methylphenidate (MPH) on the short-term memory scanning of boys with Attention Deficit Disorder (ADD) was examined from the perspectives of a linear stages model and a capacity model of information processing. A total of 36, six- to ten-year-old boys participated in three age- and …
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Concentration-dependent Effects of D-Methylphenidate on Frontal Cortex and Spinal Cord Networks in vitro
… arrays were used to study effects of D-methylphenidate. These central nervous system tissues have relatively low concentrations of dopaminergic and noradrenergic neurons compared to the richly populated loci, yet exhibit similar neurophysiological responses to methylphenidate. The …
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The Neurocognitive Sequelae of Chronic Traumatic Brain Injury and the Utility of Treatment with Methylphenidate
… cognition with pharmacological treatment i.e., Methylphenidate (MPh). This work aims to further our understanding of the detrimental functional consequences of TBI and inform targeted neurorehabilitation options. In the first experimental chapter, I use task-based functional MRI data acquired …
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EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
Methylphenidate (MPH) is one of the most commonly prescribed drugs in the United States. MPH is a psychostimulant that inhibits the dopamine (DA) and norepinephrine (NE) transporters to increase extracellular monoamines. Abuse rates of MPH are increasing as prescription rates increase, but the …
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Ventral Tegmental Area Neuronal Responses to Methylphenidate Correlated to Behavioral Responses of Adolescent and Adult Rats
<p>Methylphenidate (MPD) is a psychostimulant used in the treat treatment of attention deficit hyperactivity disorder and more recently is being used as a cognitive enhancement and recreational drug. Its therapeutic effects are not fully understood, nor are the long term effects of the drug on …
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2d quantitative structure activity relationship modeling of methylphenidate analogues using algorithm and partial least square regression
… activity (binding affinity) of a set of 80 methylphenidate analogues and to construct a predictive model. The GA code was implemented using the fitness function (1-(n-1)(1-q^2)/ (n - c)), where n is the number of compounds, c is the optimal number of components, and q^2 is the …
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Monoamine Transporter Photoaffinity Ligands Based On Methylphenidate and Citalopram: Rational Design, Chemical Synthesis, and Biochemical Application
… to develop irreversible chemical probes based on methylphenidate (MP) and citalopram (CIT), two therapeutically significant MAT inhibitors, in order to map their binding sites and poses within their major MAT target protein. The central hypothesis was that MP and CIT could be rationally …
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The Effects of Methylphenidate During Rest, Exercise, and Recovery Upon The Circulorespiratory Responses of Hyperactive Children
Made available in DSpace on 2014-12-12T01:12:25Z (GMT). No. of bitstreams: 1 7514079.pdf: 9285366 bytes, checksum: 72cb020c22e54a2d1c79b9b71fcb9805 (MD5) Previous issue date: 1975
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NICOTINE AND METHYLPHENIDATE CHORNIC EXPOSURE ON ADULT CANNABINOID RECEPTOR AGONIST (CP 55,940) PLACE CONDITIONING IN MALE RATS
… or in combination with ADHD medications, like methylphenidate (MPH), in late childhood or early adolescence and the increased likelihood of later marijuana abuse in adulthood. Pre-clinical studies have found that the use of nicotine during the early adolescence period produces enduring changes …
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METHYLPHENIDATE TREATMENT AND REARING ENVIRONMENT: EFFECTS ON THE DOPAMINE SYSTEM AND VULNERABILITY TO SUBSTANCE ABUSE IN ANIMAL MODELS
… was to investigate the effects of chronic methylphenidate treatment, at doses that have been associated with clinical efficacy in children, on the dopamine system and vulnerability to substance abuse in animal models. Methylphenidate is the most commonly prescribed stimulant to treat …
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Effects of Atomoxetine and Methylphenidate on functional brain activation in Medication-naive children with Attention Deficit Hyperactivity Disorder
… Hyperactivity Disorder (ADHD), the stimulant methylphenidate (MPH), and the non-stimulant Atomoxetine (ATX) in ADHD. Brain activation and task performance during motor inhibition (Stop), time discrimination (TD) and working memory (WM) tasks were compared in 20 medication-naive ADHD boys …
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