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Showing 1 to 20 of 36 for “"Methylglyoxal"”.
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Spectroscopy and Photophysics of Methylglyoxal
Made available in DSpace on 2015-05-13T15:17:42Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7606736.PDF: 4397123 bytes, checksum: 6e084405beeb507f6d5d8af1695360b7 (MD5) Previous issue date: 1975
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Kinetics of Conversion of Dihydroxyacetone to Methylglyoxal in Honey
… after due to the perceived health benefits. Methylglyoxal (MGO) is the compound predominately responsible for this non-peroxide activity (NPA). Varying levels of dihydroxyacetone (DHA) are found in mānuka nectar which converts to MGO once honey is harvested; however, this is not a 1:1 …
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Enhanced methylglyoxal formation in cystathionine γ-lyase knockout mice
Methylglyoxal (MG) is a reactive glucose metabolite and a known causative factor for hypertension and diabetes. Hydrogen sulfide (H₂S), on the other hand, is a gasotransmitter with multifaceted physiological functions, including anti-oxidant and vasodilatory properties. The present study …
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Mechanisms of Chemiluminescence
… of this dissymmetric dioxetane to acetone and methylglyoxal proceeds with an activation energy of 26.0 (+OR-) 1 kcal/mol and a log A of 14.2. The enthalpy of activation and entropy of activation were determined to be 25.5 (+OR-) 1.0 kcal/mol and 4.0 (+OR-) 2 eu, respectively. The total yield of …
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Combinational Therapy to Mitigate α-Dicarbonyl Toxicity
… of reactive α-dicarbonyls (α-DCs) like, methylglyoxal (MGO). The abundance of α-DCs form advanced glycation end products (AGEs); in turn, the accumulation of AGEs has been linked to secondary complications. Secondary complications include diabetic neuropathy, nephropathy and …
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DEVELOPING CHEMICAL TOOLS TO MAP MOLECULAR MECHANISMS THAT DRIVE DISEASE
… implications of elevated intracellular methylglyoxal concentrations, and the development of small molecule epigenetic modulators to regulate aberrant DNA methylation. Chapters I, II, and III of this thesis explores how dysregulated dopamine may contribute to Parkinson’s disease …
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Argininderivatisierung und 1,2-Dicarbonylverbindungen in Lebensmitteln
… in Lebensmitteln Glyoxal (GO), Methylglyoxal (MGO), 3-Desoxyglucosulose (3-DG) und 3-Desoxypentosulose (3-DPs) konnten nach Umsetzung mit o-Phenylendiamin erstmals in Milch- und Milchprodukten quantifiziert werden. Für Glyoxal wurden Gehalte von 0,06 bis 3,5 mg/ l und für …
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Acquisition of an Antibiotic Tolerant Phenotype in Enterobacter cloacae and Klebsiella pneumoniae through Antibiotic-Induced Metabolic Regulation
… treated and untreated isolates. I identified the methylglyoxal pathway as a candidate pathway that bacteria can use to acquire antibiotic tolerance due to its ability to decrease ATP production in the cell, leading to metabolic downregulation. A panel of clinical isolates of Enterobacter cloacae …
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Cellular Mechanisms Involved in Reactive Carbonyl and Hyperinsulinemia Enhancement of Diabetic Complications
… and finally (3) the reactive carbonyl methylglyoxal enhances chemotherapeutic drug-dependent cytotoxicity. We report that hyperinsulinemia decreases survival of serum deprived B-cells through a PI 3-kinase and JNK pathway. We describe a mechanism where rapamycin sensitive …
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Methanocaldococcus jannaschii and the Recycling of S-adenosyl-L-methionine
… be the source of deoxysugars for the production methylglyoxal, a precursor for aromatic amino acids. MTIP and MTRI were demonstrated to produce 5-deoxyribulose 1-phosphate from 5'-dI. Additionally, two enzymes annotated as part of the pentose phosphate pathway, ribulose 5-phosphate 3-epimerase …
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Quantum Beat Spectroscopy and Radiationless Transitions
… excitation spectra of the series glyoxal-h(,2), methylglyoxal-h(,4), methylglyoxal-d(,4), biacetyl-h(,6), and 2,3-pentanedione-h(,8) at high resolution show that except for glyoxal these molecules undergo a characteristic structural deformation during the electronic transition. Our nearly …
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Laser-Induced Fluorescence Studies of Molecular Dynamics
… fluoresence excitation spectra of biacetyl, methylglyoxal, and pentanedione have been recorded for the excited singlet state of each molecule. In particular, the fluorescence of biacetyl in a molecular beam has been shown to exhibit the quantum beat effect in the time-resolved fluoresence. By …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… highly reactive and toxic α-dicarbonyls, such as methylglyoxal (MGO) derived from glycolysis, is associated with various age-related diseases including diabetic complications and neurodegenerative diseases. Aging and long-term hyperglycemia causes enhanced production of this highly reactive …
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A study of the Project for American Studies in the Secondary Schools and its effect on curricular change
… spermine remains consistently low.6. Addition of methylglyoxal bis (guanylyhdrazone) inhibits tumor growth, but the inhibitory effect is decreased by concurrent administration of spermidine.7. Both novobiocin and nalidixic acid have an inhibitory effect on tumor growth, but the effects are …
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Nucleotide Inhibition of Glyoxalase II
The glyoxalase system mediates the conversion of methylglyoxal, a toxic ketoaldehyde, to D-lactic acid. The system is composed of two enzymes, glyoxalase I (Glo-I) and glyoxalase II (Glo-II), and exhibits an absolute requirement for a catalytic quantity of glutathione (GSH). Glo-I catalyzes the …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
… (Glo-1) activity with [2-<sup>13</sup>C]Methylglyoxal for detecting metabolic heterogeneity between breast and ovarian cancer PDXs. However, Glo-1 activity did not differ between ovarian or breast cancer subtypes and therefore while <sup>13</sup>C MRSI with [2-<sup>13</sup>C]Methylglyoxal …
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Adaptive Immunity in Cardiovascular Disease
… helper subsets and studies on antibodies against methylglyoxal-modified apolipoprotein B100 (MGO-ApoB100). In the prospective Malmö Diet and Cancer cohort we studied the relation of T helper 1 (Th1) and T helper 2 (Th2) cells to future cardiovacular events. We found that baseline-levels of Th2 …
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Flavor development in lactic fermentation of ultrafiltered cottage cheese whey
… increased the production of glyoxal, methylglyoxal, and diacetyl as detected by high performance liquid chromatography.</p>
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Aqueous-phase Organic Chemistry in the Atmosphere
… aqueous-phase OH oxidation of glyoxal and methylglyoxal. Quantification of all the major reaction products was achieved, permitting complete reaction mechanisms to be presented. An unexpected class of compounds, α-hydroxyhydroperoxide (α-HHP), was observed during the experiments, and the …
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