Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Methylation signatures"”.
-
A Method for Identification of Pancreatic Cancer through Methylation Signatures in Cell-Free DNA
… to screen for early signs of disease. DNA methylation signatures found in cfDNA can serve as a biomarker for detection of cancer. Previous efforts to detect pancreatic cancer using cfDNA showed limited sensitivity for detection. This manuscript describes work to develop a method for early …
-
Functional genomics of developmental disorders
DNA methylation, or the epigenetic modification of primarily cytosine bases within DNA to 5-methylcytosine through the addition of a methyl group, is an epigenetic mark with a variety of biological and cellular roles. Genetic and environmental influences can perturb DNA methylation patterns in …
-
Deconvolute Brain Tumor Genomic Alterations Based On Dna Methylation
… is associated with genome-wide hypermethylation of CpG islands in gliomas. But other subtype-associated alterations, including telomerase reverse transcriptase (<em>TERT</em>)<em> </em>promoter mutation, alpha thalassemia/mental retardation syndrome X-linked (<em>ATRX</em>) mutation, …
-
DNA methylation in early mammalian development
… by epigenetic modifications, including DNA methylation. In this thesis, I analyze genome-scale DNA methylation profiles across pre-implantation development to identify the targets and characterize the dynamics of global demethylation that lead to totipotency and the subsequent changes to …
-
Investigating CD8+ T-cell gene expression signatures as disease prognostic biomarkers in paediatric inflammatory bowel disease.
… in adult IBD cohorts identified promising signatures, including a T-cell exhaustion signature, to predict disease outcome in these patients. Hypothesis and aim: We hypothesised that adult CD8+ T-cell prognostic signature and T-cell exhaustion signature would also predict outcome in …
-
Social-Demographics, Health Behaviors, Telomere Length In Mexican-American Cohort and Circulating Dna Methylation In Bladder Cancer
… with age (r=-0.15, p</p> <p><strong>II. METHYLATION IN SERUM CELL-FREE DNA AND CPG-SNP WITH BLADDER CANCER RISK</strong></p> <p>Epigenetic alterations are early events of cancers, including bladder cancer. In the present study, we aimed to examine methylation profiles of circulating DNA …