Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 999 for “"Methylation"”.
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DNA Methylation: Methods and Analyses
… using the high-throughput, cost-effective HumanMethylation450 microarray (450k) developed by Illumina. With the recent release of the HumanMethylationEPIC microarray, the size of data is expected to increase considerably so advances are needed in the methodologies used to analyse such data. The …
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On the Analysis of DNA Methylation
… support to the idea that the patterns of DNA methylation are in some way related either causally or as a readout of cell-type specific protein binding. We lay the groundwork for a framework to test whether the pattern of DNA methylation levels in a cell combined with protein binding models is …
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APPROACHING DNA METHYLATION AT THE NANOSCALE
… modulation have been extensively studied: DNA methylation, histone post-translational modification, non-coding RNA, and nuclear organization. A fast-growing body of evidence suggests that epigenetic mechanism plays a fundamental role in physiology and pathology. Of the elucidated epigenetic …
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The methylation of aminopteridines and aminopyrimidines
This thesis describes the methylation of a number of aminopteridines and aminopyrimidines. In actual fact however, it consists of much more than an investigation of one type of reaction, since emphasis has been placed upon the chemistry of the methylation products and the manner in which they can …
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The methylation of aminopteridines and aminopyrimidines
This thesis describes the methylation of a number of aminopteridines and aminopyrimidines. In actual fact however, it consists of much more than an investigation of one type of reaction, since emphasis has been placed upon the chemistry of the methylation products and the manner in which they can …
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Methylation and High Dimensional Data Integration
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo terms
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DNA methylation: the "stable" epigenetic mark
DNA methylation is regarded as a stable epigenetic mark given its faithful maintenance across successive cell divisions. Methylation occurs at most CpG sites in mammalian genomes and is generally associated with transcriptional repression. An accepted evolutionary role for DNA methylation is to …
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Shape-selective methylation of meta-cresol
… isomers was investigated via acid catalysed methylation of m-cresol with methanol, and focusing on shape-selective or potentially shape-selective zeiolites and the effects of varying reaction parameters. Attention was drawn to specifically producing the "slim" isomers, 2,5-xylenol and …
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DNA methylation in early mammalian development
… by epigenetic modifications, including DNA methylation. In this thesis, I analyze genome-scale DNA methylation profiles across pre-implantation development to identify the targets and characterize the dynamics of global demethylation that lead to totipotency and the subsequent changes to …
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Tissue- specific DNA methylation profiles in newborns
… tissues are a suggested mechanism of which DNA methylation is best understood. DNA methylation profiles in human tissue are mostly performed in DNA from white blood cells. The objective of this study was to assess DNA methylation profiles of IGF2 DMR and H19 in DNA derived from four tissues of …
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REDEFINING PROMOTER DNA METHYLATION CHANGE IN CANCER
Promoter DNA methylation has been recognized for decades as one of the major mechanisms of epigenetic gene regulation and has consistently been found to be perturbed during cancer development. However, among the many genomic regions that have been found to display altered methylation in different …
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Regulation of PAX6: DNA methylation and MicroRNAs
… of PAX6, which are microRNAs (Study 1) and DNA methylation (Study 2 and Study 3), respectively. Study 1 examines three predicted microRNA-7 (miR-7) target sites within the 3'untranslated region (3'UTR) of the human PAX6 gene. A Luciferase reporter assay demonstrates that two of the predicted …
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Inferential Methods for High-Throughput Methylation Data
The role of abnormal DNA methylation in the progression of disease is a growing area of research that relies upon the establishment of sound statistical methods. The common method for declaring there is differential methylation between two groups at a given CpG site, as summarized by the difference …
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Regulation of Set1-Mediated Methylation of Dam1
… of posttranslational modifications including methylation, phosphorylation, and ubiquitination, which are integral to a range of DNA-templated processes including transcriptional regulation. A hallmark for transcriptional activity is methylation of histone H3 on lysine (K) 4 within active gene …
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Carboxyl Methylation of Non-Histone Chromosomal Proteins
<p>The <u>in vitro</u> methylation of non-histone chromosomal proteins (NHCP) was investigated in nuclei isolated from the brain, liver, and thymus of 6-8-day-old rats. After incubating the nuclei in the presence of 20 μM S-adenosyl-L-[methyl-<sup>3</sup>H]methionine(l Ci/mmol), the NHCP were …
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DNA methylation in the early porcine embryo
… effects on the epigenetic factor of cytosine methylation in cytosine-guanine dinucleotides. The purpose of this research is to study the dynamics of DNA methylation in porcine gametes, clonal cell lines, adult somatic cells, and early embryos produced by using in vivo, in vitro, …
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Regeneration, DNA Methylation, and Transformation in Rosaceae
The effects of different concentrations of kanamycin, carbencillin, cefotaxime, and combinations of carbencillin and cefotaxime on regeneration from different tissues of rose (Rosa hybrida cv. Carefree Beauty) were investigated. Agrobacerium tumefaciens strain GV3101 containing pCAMBIA 2301 plasmid …
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Chemotactic Methylation in Bacillus Subtilis (Chemosensory, Adaptation)
… and away from high concentrations of repellents. Methylation and demethylation of methyl-accepting chemotaxis proteins (MCPs) has been demonstrated to play a central role in this process. The goal of this work was to clarify the nature of the response of the Bacillus subtilis …
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Regulation of yeast development by mRNA methylation
The internal methylation of mRNA post-transcriptionally is an essential component of the mRNA editing machinery in virtually every eukaryotic system. Despite this ubiquity, little is known about the relevance, consequences or machinery involved in this process. The recent demonstration of this …
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