Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Methylating agents"”.
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Homology-Directed Repair of Dna Lesions Generated by the Mismatch Repair Dependent Processing of Cytotoxic Guanine Adducts
<p>Methylating agents are widely used in chemotherapy and kill cancer cells by causing DNA damage. The O6-methylating anticancer drugs procarbazine, dacarbazine, and temozolomide generate O6-MeG adducts, while a thiopurine antimetabolite 6-thioguanine (6-thioG) generates S6-MeG DNA adducts. Instead …
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
Methylating agents are ubiquitous in our internal and external environments and can cause damage to all cellular components, including our DNA. If left unrepaired, methylated DNA can cause mutations, cell death, and disease, such as cancer and neurodegeneration. The majority of DNA lesions caused …
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ΜΕΤΑΛΛΑΞΟΓΕΝΕΣΗ ΚΑΙ ΕΝΕΡΓΟΠΟΙΗΣΗ ΤΟΥ RAS ΟΓΚΟΓΟΝΙΔΙΟΥ ΑΠΟ ΑΛΚΥΛΙΩΤΙΚΟΥΣ ΚΑΡΚΙΝΟΓΟΝΟΥΣ ΠΑΡΑΓΟΝΤΕΣ
… AND PRECARCINOGENIC LESION INDUCED BY METHYLATING AGENTS, WAS INTRODUCED, BY MEANS OF SITE-DIRECTED MUTAGENESIS, INTOTHE CODONS 12 AND 13 OF THE HUMAN HA-RAS1 PROTO-ONCOGENE. THE 06MEG MUTAGENESIS WAS STUDIED IN E. COLI CELLS OF DIFFERENT REPAIR CAPACITIES: 1) O6MEG INDUCEDEXCLUSIVELY …
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Role of TLS Polymerases in Replication of DNA Lesions in Human Cells
… lesions result from exposures to endogenous methylating agents and naturally occurring methyl halides. They might interfere with base pairing and are cytotoxic. The long-term goal is to understand the mechanisms by which replication through such ubiquitous lesions occurs in human cells. …
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Folate: Friend or Foe? An investigation into the opposing roles of folate in glioma
… methylation is often seen in glioma cells, but methylating agents such as folate, may reverse aberrant methylation. Folate treatment has shown a beneficial effect, reducing risk of certain cancers (colorectal, breast, squamous cell carcinoma) but other studies have shown detrimental results …
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Understanding cell fate decisions in response to 0⁶-Methylguanine DNA lesions
… by both endogenous and exogenous DNA damaging agents. DNA damage, if left unrepaired, can give rise to permanent genetic alterations that ultimately increase our risk of cancer and other diseases. To combat these threats, eukaryotic cells activate a DNA damage response (DDR) that coordinates a …
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Synthetic approaches to the understanding of DNA nucleobase methylation
… occurs when nucleophilic DNA bases react with methylating agent methyl methanesulfonate (MMS), dimethyl sulfate (DMS), N-methyl-N-nitrosourea (MNU), N-methyl-N-nitro-N-nitrosoguanidine (MNNG), etc. N7-methyl-2'-deoxyguanosine (N7-methyl-dG, or ^{7Me}dG) adduct is the most abundant DNA …
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The Role of Hiwi in Stem Cell Maintenance and Sarcomagenesis
… tumorigenic effects are reversible using DNA de-methylating agents. These studies reveal for the first time not only a novel oncogenic role for Hiwi as a driver of tumorigenesis, but also suggest that the use of epigenetic agents may be clinically beneficial for treatment of tumors that express …
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Studies on the mechanism of action on antitumour imidazotetrazinones
… are clinically active antitumour agents, temozolomide currently proving successful in the treatment of melanomas and gliomas. The exact nature of the biological processes underlying response are as yet unclear.This thesis attempts to identify the cellular targets important to the …