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Showing 1 to 7 of 7 for “"Methyl-coenzyme M Reductase"”.
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The Methyl-Coenzyme M Reductase System in Methanobacterium Thermoautotrophicum
Made available in DSpace on 2014-12-14T07:14:45Z (GMT). No. of bitstreams: 1 7804010.pdf: 4777401 bytes, checksum: fc91aa47a8e3f2b0af685858c4c06d47 (MD5) Previous issue date: 1977
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Recombinant Expression and Assembly of Methyl Coenzyme-M reductase
Methyl-coenzyme M reductase (MCR) is the key enzyme involved in the production of methane by methanogenic archaea and its consumption by anaerobic methanotrophs (ANME). MCR is a multimeric complex composed of six different subunits arranged in a 2α, 2β, 2γ configuration that requires two molecules …
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Post-translational modifications of methyl-coenzyme m reductase in methanosarcina acetivorans
Methyl-coenzyme M reductase (MCR) catalyzes the last step in methanogenesis and the first step in anaerobic methane oxidation, producing gigatons of methane annually and playing a vital role in the biological methane cycle. This enzyme is found solely in methanogenic and methanotrophic archaea, …
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The F(430) cofactor of methyl coenzyme M reductase: Ligand binding to the nickel and chemical modification of the tetrapyrrole substituents
… and spectroscopic studies on the nickel enzyme methyl-CoM reductase from M. thermoautotrophicum (strain $\Delta$H) were undertaken to better characterize the nickel site. The major goals of this work are two-fold: (1) To further characterize the molecular and electronic structure of the …
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The structure and reactivity of metallohydroporphyrins
… biological systems including nitrite and sulfite reductases and S-methyl coenzyme M reductase. Of particular interest is the highly reduced nickel-containing macrocyclic tetrapyrrole F$\sb{430}$, found in the latter enzyme of methanogenic bacteria. This cofactor possesses the most highly reduced …
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Functional and mechanistic elucidation of peptide backbone thioamidation
… modification in two essential protein complexes: methyl-coenzyme M reductase (MCR) and the ribosome. Genetic studies in the methanogen Methanosarcina acetivorans have linked the thioamide in MCR with ycaO and its neighboring gene tfuA, which has no known function. In this thesis, I report the in …
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Investigating the Distribution and Biosynthesis of Modified F<sub>430</sub> Cofactors in Methanogenic and Methanotrophic Archaea
… convert natural gas into liquid fuels. Methyl coenzyme M reductase (Mcr) catalyzes the final reaction of methanogenesis in methanogens and the first reaction in the anaerobic oxidation of methane (AOM) carried out by the anaerobic methanotrophs (ANME). Cofactor F<sub>430</sub>, a unique …