Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Methyl-CpG-Binding Protein 2"”.
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Exploring induced secondary structure and unmethylated DNA binding domains of methyl CpG binding protein 2 (MeCP2)
Our understanding of Methyl CpG binding protein 2 (MeCP2) structure and function has changed and expanded considerably over the last two decades. Mutations along the entirety of the human MeCP2 gene product lead to a disease state - Rett syndrome. The clinical connection of this protein has …
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Characterizing interactions between cAMP responsive element binding protein 1 and methyl-CpG-binding protein 2 as a potential transcriptional activation complex
… activity is controlled by many types of DNA binding proteins. In addition to transcription factors that activate transcription by recruitment of RNA polymerase II, there are proteins like methyl-CpG-binding protein 2 (MeCP2). MeCP2 regulates transcription by binding to methylated DNA. MeCP2 …
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A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
Methyl CpG binding protein 2 (MeCP2) was originally characterized as a transcriptional repressor that preferentially bound methylated DNA, however, recent data indicates MeCP2 is a multifunctional protein. MeCP2 is now shown to associate with expressed genes as well as repressed genes indicating …
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MicroRNA and Epigenetic Controls of CD4+ T cells' Activation, Differentiation and Maintenance
… leads to the accumulation of DNMT1, elevated CpG methylation in the foxp3 promoter, and suppression of foxp3 transcription. Furthermore, we demonstrated that an epigenetic regulator, methyl CpG binding protein 2 (MeCP2), is critical to sustain Foxp3 expression in Tregs, and to support Th1 and …
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Biomolecular Condensates in Transcriptional Regulation
… of specific components. Notably, we find that methyl-CpG binding protein 2 (MeCP2) is a key component of heterochromatin condensates. Mutations in MeCP2 cause the neurodevelopmental disorder Rett syndrome, and we link disease-causing mutations in MeCP2 to the disruption of heterochromatin …
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Lung Defects Contribute to Respiratory Symptoms in a Mecp2-mutant Mouse Model of Rett Syndrome
… caused by mutations in the X-linked gene, methyl-CpG-binding protein 2 (MECP2). After a period of seemingly normal post-natal development, RTT patients experience a developmental regression, consisting of loss of acquired verbal and motor skills, stereotypic hand movements, respiratory …
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Human induced pluripotent stem cell models of Rett Syndrome reveal deficits in early cortical development
… by sporadic mutations in the gene encoding methyl CpG-binding protein 2 (MeCP2), which is expressed in the brain during prenatal neurogenesis and continuously throughout adulthood. MeCP2 is a pleiotropic gene that functions as a complex, high-level transcriptional modulator. It both …
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Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
… mechansomes contain an adhesion-associated protein and a nucleocytoplasmic shuttling transcription factor. “GO” mechanosomes functions to promote the anabolic response of bone to mechanical loading, while “STOP” mechanosomes function to suppress the anabolic response of bone to mechanical …
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… in one such gene, the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2), lead to a form of mental retardation called Rett Syndrome (RTT). Though the MeCP2 protein is expressed ubiquitously, symptoms of RTT patients are primarily neurological, which include reduced mental capacity, …
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Decoding 5HMC as an Active Chromatin Mark in the Brain and its Link to Rett Syndrome
… such as histone modifications and DNA methylation, that are frequently altered in neurological disorders. 5-hydroxymethylcytosine (5hmC), a recently identified DNA base derived from 5-methylcytosine, accounts for ~40% of modified cytosines in the neuronal genomes, suggesting that 5hmC …
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THE INTERPLAY BETWEEN HPCAL4 AND MECP2: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PUTATIVE TARGET FOR RETT SYNDROME THERAPY
… within the X-linked gene coding for the methyl-CpG binding protein 2 (MeCP2). It is an important epigenetic regulator that is ubiquitously expressed and particularly abundant in brain and important for proper neuronal maturation and function. In fact, MeCP2 deficiency in neurons is …
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Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
… we and others have demonstrated that the methyl-CpG-binding protein 2 (MeCP2) contributes to both neural and behavioral adaptations induced by repeated psychostimulant exposure (Deng et al, 2010, Im et al, 2010). Psychostimulants induce rapid and robust phosphorylation of MeCP2 at Ser421 …
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NEURAL PRECURSOR/STEM CELL-BASED THERAPY: A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF RETT SYNDROME
… mutations in the MECP2 gene encoding for the methyl-CpG binding protein 2 (MeCP2), an epigenetic factor involved in gene transcription regulation and chromatin remodeling, particularly abundant in the central nervous system. RTT features include cognitive and motor impairments, hand …
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Making Molecular Movies: Using Single-Molecule Techniques to Unveil Hidden Features of Protein-Chromatin Interactions
… that regulates the function of every DNA-binding protein that exists. These proteins can assemble, translocate, and change conformation while bound to DNA and can even alter its physical state, which are often crucial to their physiological roles in the cell. Eukaryotic genomic DNA is also …