Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"Methicillin-resistant Staphylococcus aureus (MRSA)"”.
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Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in a university medical center day care facility
BACKGROUND: Few data are available on MRSA colonization in day care. We performed a study in a medical university child care center to determine the epidemiology of MRSA in this population. \r\n\r\nMETHODS: A cross sectional study was done involving 104 day care attendees and 32 adult employees. …
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Mechanistic Study of Antimicrobial Cyclic Peptide [R4W4] Antibacterial Effectiveness against Methicillin-resistant Staphylococcus aureus (MRSA)
… <em>Escherichia coli</em> (<em>E. coli)</em> and Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) by checkered board assay. The MRSA resistant to [R<sub>4</sub>W<sub>4</sub>] and possibility with other antibiotics was evaluated with serial passage. Moreover, we investigated the …
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MRSA: A Global Threat
Methicillin-resistant Staphylococcus aureus (MRSA) is the cause to some of the most common infections in the world. Its molecular distribution does not show the dissemination of one global strain. Studies show that, although community-acquired MRSA is more common in the United States, …
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The identification and characterization of a clinical isolate of a methicillin susceptible Staphylococcus aureus ST612
A previous study of 100 methicillin-resistant Staphylococcus aureus (MRSA) isolates, collected between January 2007 and December 2008 from five Cape Town hospitals, identified ST612-MRSA-IV as the predominant MRSA. This raised the question of whether methicillin-susceptible S. aureus (MSSA) …
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TARGETING MULTI-DRUG RESISTANT PATHOGENS WITH NOVEL ANTIMICROBIAL PEPTIDES
… In the United States alone, antibiotic-resistant bacteria infect at least two million people and kill around 23,000 patients each year. Half of these infections are attributed to the bacterial pathogen, methicillin resistant Staphylococcus aureus (MRSA) according to a report published in …
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In Vivo Imaging of Neutrophil Responses to Localized S. aureus Infection
Methicillin-resistant Staphylococcus aureus (MRSA) is a highly virulent, multidrug –resistant pathogen responsible for the majority of soft tissue infections. The role of neutrophils in S. aureus soft tissue infections is currently unclear. The objective of this thesis was to characterize early …
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MULTIPLEX ASSAY DESIGN
… Enterobacteriaceae (CPE), vancomycin-resistant Enterococcus (VRE) and colistin resistance has been developed in this thesis. The resulting amplicons can be distinguished based on the principles of size, melting-state transitions, and sequence-specific probes. The problem of …
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Surgical Site Infection Reduction Through Nasal Decolonization Prior to Surgery
… patients. The process involved screening for methicillin-resistant Staphylococcus aureus (MRSA) colonization via nasal swab preoperatively and treating positive patients with mupirocin ointment to nares BID and chlorhexidine showers for five days prior to surgery. Adherence to the protocol was …
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Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
… (RCFs) act as reservoirs for multidrug-resistant organisms (MDRO). There are scarce data on colonisation with MDROs in Africa. We aimed to determine the prevalence of MDROs and C. difficile and risk factors for carriage amongst residents of RCFs in Cape Town, South Africa. Methods We …
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Discovery and functional study of the novel bioactive peptide QUB-1980 from the skin secretion of Odorrana grahami
… to display weaker antimicrobial activity against Staphylococcus aureus (S. aureus) (ATCC CRM 6538), Escherichia coli (E. coli) (ATCC CRM 8739) and Candida albicans (C. albicans) (ATCC CRM 10231) than the natural peptide. Compared with natural peptide, QUB-1347NH2 showed better ability against …
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Ring-fencing : a strategy to enhance elective surgery performance
… as they have been previously screened for methicillin-resistant Staphylococcus aureus (MRSA) and staffed by a dedicated team of nurses and therapists. By providing a separate area for elective surgeries, the primary benefits of protected elective surgical units are their ability to reduce …
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Remote asymmetric induction in the organocatalytic azaDarzens synthesis of peptide aziridines: towards the assembly of new glycopeptide antibiotic analogues
… is used as a drug of last resort against methicillin-resistant Staphylococcus aureus (MRSA), but the increasing prevalence of vancomycin-resistant bacteria has intensified the search for new antibiotics. The introductory chapter of this thesis presents an overview of publications reporting …
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Institutional and Patient Level Predictors of Multi-Drug Resistant Healthcare-Associated Infections
… infections (HAI) caused by multi-drug resistant organisms (MDRO) are an important patient safety concern resulting in a substantial financial and clinical burden. This dissertation aims to contribute to the evidence base on institutional and patient level factors that predict multi-drug …
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Natural product chemistry in drug discovery
… among plant-derived compounds active against methicillin-resistant Staphylococcus aureus (MRSA). It links reported antibacterial activities to structural features, identifies molecular motifs associated with anti-MRSA efficacy, and proposes lead structures for further investigation. The second …
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Perceptions of Certified Athletic Trainers regarding Methicillin-Resistant Staphylococcus Aureus Prevention Strategies
Methicillin Resistant Staphylococcus Aureus (MRSA) has been receiving significant attention, highlighting an increased risk of infectious transmission associated with athletic participation. As MRSA infections are becoming increasing virulent, athletic trainers are presented with immediate …
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A Mathematical Model For Optimal Admission Screening For Methicillin Resistant Staphylococcus aureus In Acute Care Facilities
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare associated infections (HAIs) worldwide. It has both an economic and personal cost to the healthcare system and infected individuals. Admission screening for MRSA is one method to detect MRSA entering the acute …
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Prevalence and Characterization of Staphylococcus Species, Including MRSA, in the Home Environment
… of this study is to assess the prevalence of Staphylococcus, including Methicillin-Resistant Staphylococcus aureus (MRSA), in a home environment. Staphylococcal species are among the most common bacteria causing joint infections, and emerging methicillin-resistant Staphylococcus aureus strains …
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Fabrication of intensity-based Long-Period-Gratings fiber sensor with CO2 Laser
… and verification of pathogenic bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA), Francisella tularensis, and so on. We have previously demonstrated that a UV-induced long-period-grating (LPG) based fiber sensor is extremely sensitive to small variation of refractive index (RI) …
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Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2
… impossible, to treat and cure. In recent years, methicillin-resistant Staphylococcus aureus (MRSA) has emerged as one of the most threatening resistant strains. MRSA infections are now responsible for more deaths each year than AIDS in the United States.4 Due to the multidrug resistance of these …
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Development and evaluation of novel antimicrobial solutions against biofilms and planktonic microbial growth
… the four microorganisms, Pseudomonas aeruginosa, Methicillin Resistant Staphylococcus aureus (MRSA), Candida albicans, and Bacillus cereus endospores. The Planktonic assay demonstrated the effectiveness of these solutions as high-level disinfectant solutions per FDA standards, which includes use …
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