Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Methacholine"”.
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Sensory-Mechanical Responses to High-Dose Methacholine Bronchoprovocation: The Modulating Effects of Deep Inspirations
… asthma (CA), cough variant asthma (CVA), and methacholine (MCh)-induced cough with normal airway sensitivity (COUGH) are incompletely understood. Defining the range of normal responses associated with deep inspirations (DIs) during high-dose MCh is key to understand the clinical relevance of …
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A Study of the Action of Prostaglandin F2a on the Guinea-Pig Isolated Trachea
… PGF2a possesses a weak inhibitory activity on methacholine-induced tracheal tone. That this inhibitory activity is not mediated through the beta- adrenergic receptor was shown in experiments where beta blocker (MJ 1999) failed to inhibit the activity of PGF2a. Inhibition of methacholine-induced …
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AN INVESTIGATION OF THE MECHANISM BY WHICH ALUMINIUM AND OTHER POLYVALENT CATIONS INHIBIT ECCRINE SWEATING
… in 0,01 ml of isotonic saline) of carbachol and methacholine and also by localised heat stress, These effects could all be reduced or abolished by prior administration of atropine ( 100 - 750 ug/kg). Systematically administered isoprenaline (400 µg/kg) was found to be more effective than either …
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THE IMPACT OF ACROLEIN ON LUNG FUNCTION: EXPLORATION OF NITROSATIVE STRESS-INDUCED LUNG INJURY AND THERAPEUTIC APPROACHES
… conduct Forced Oscillation Techniques (FOT) with methacholine nebulization to understand the dynamic airway responsiveness as well as Negative Pressure Forced Expiration (NPFE) to determine the static airway properties to determine lung compliance. In addition to using mechanical measurements of …
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Predictors of obstructive lung disease among seafood processing workers along the west coast of the Western Cape of South Africa
… airborne allergen. Lung function spirometry and methacholine challenge tests (tidal breathing method) conducted using Vitallograph S-model bellows volume-time spirometers according to ATS guidelines. Serum omega-3 and omega-6 fatty acid levels also analysed to examine the association between …
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Effort-Independent Asthma Severity Classification
… We show that for an adult population undergoing methacholine challenge pulmonary function testing, capnography recordings from subjects with asthmatic exacerbation may be distinguished from their normal/baseline recordings with an AUROC of 0.92 (0.84 -- 1.00). Additionally, using data from an …
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A Study of the Adrenergic Receptors in Mammalian Tracheal Smooth Muscle
… did not affect the contractile response to methacholine. Thus, alpha-adrenergic receptors have been demonstrated in the tracheal muscles of man and guinea-pig. | Studies on the effect of cortisol on the beta-adrenergic action of catecholamines on guinea-pig tracheal smooth muscle were done. …
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Development and validation of a diagnostic tool for occupational asthma based on serial lung function measurements
… FENO. FENO was significantly correlated to methacholine reactivity. In shift workers, mean ABC scores were increased on morning shifts compared to nights, but the cut off of 15 L/min/h would be applicable across all shift types. The ABC score is a new robust method of confirming occupational …
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Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy
… respiratory abnormalities in KO mice using the methacholine (MCh) challenge, indicating that increased breathing rate, apnea and respiratory failure is associated with SUDEP. We have also found that the metabolic therapy, ketogenic diet (KD), significantly reduces seizures and prolongs lifespan …
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Learning and model-based approaches to improved patient monitoring, assessment and treatment in capnography and procedural sedation
… capnograms of 25 asthmatic patients undergoing a methacholine challenge showed approximately a third fewer exhalations classified as normal when challenged with methacholine, and approximately a third more exhalations classified as normal when treated with bronchodilators after the challenge. …
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Histamine Metabolism During Asthma Induced By Inhalation Challenge
… first second (FEV(,1)) in 18 subjects inhaling methacholine(MCH) by increments to permissible limits of 224 cumulative units (cu). HM was measured in plasma ultrafiltrates by an isotropic assay based upon the specificity of HM-N-methyltransferase harvested from rat brains. DAO was determined …
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From sneeze to wheeze: Non-invasive studies on asthma and rhinitis
… perception of the obstruction induced during methacholine challenge test compared to patients with rhinitis and bronchial hyperresponsiveness. By using non-invasive techniques such as induced sputum, exhaled nitric oxide and impulse oscillometry in addition to bronchial provocation tests we …
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
… ELISA. RESULTS: P113 treatment decreased AHR to methacholine and airway inflammatory cell numbers in BAL fluid following OVA challenge (P< 0.01, respectively), attenuated the levels of Th2 cytokine such as Interleukin(IL) -4, IL-5 and IL-13, but not Th1 cytokine in the BAL fluid. The numbers of …
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Predictors of obstructive lung disease among seafood processing workers along the West Coast of the Western Cape of South Africa
… airborne allergen. Lung function spirometry and methacholine challenge tests (tidal breathing method) were conducted using Vitallograph S-model bellows volume-time spirometers according to ATS guidelines. Serum omega-3 and omega-6 fatty acid levels were also analysed to examine the association …
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A Novel Mouse Model of Asthma Induced by Cockroach
… can induce airway hyper-responsiveness (AHR) to methacholine, eosinophilic and neutrophilic inflammation, and airway mucus gland hyperplasia. Endotoxin added in CR attenuated eosinophilic inflammation, IL-13 in BAL fluid, and goblet cell hyperplasia of respiratory epithelium, however, did not …
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Isolation and partial characterization of three members of the GGR-1 family in the parasitic nematode Haemonchus contortus
… to acetylcholine, and to a higher degree, methacholine. A ligand for the Hco-GGR-2 homomeric channel has not yet been identified. Additionally, homology modelling of Hco-LGC-39 and Hco-LGC-40 provided further insight into receptor ligand interactions, and helped to identify several residues …
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The regulation of allergic airway disease by type V collagen-induced tolerance
… challenge. Airway hyper-responsiveness (AHR) to methacholine was measured; and RT-PCR utilized to determine local Il17 transcripts. Bronchoalveolar lavage levels of C3a¸ C5a and OVA-specific IgE were measured; and immunohistochemistry utilized to detect expression of complement regulatory …
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Characterization of the airway epithelial bioelectric mechanisms associated with the effects of epithelium-derived relaxing factor in guinea pig-isolated trachea
… events as well as airway reactivity to methacholine (MCh). In vitro tracheal smooth muscle contractile and relaxant responses as well as V ms responses were measured utilizing the isolated and modified isolated, perfused trachea apparatuses while the two-chambered, whole-body …
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Genetic Effect of MBL2 Polymorphisms in Patients with Diisocyanate-induced Occupational Asthma
… G>C, and ht2 [CAG] had significantly lower PC20 methacholine levels (P=0.030, and P<0.001, respectively) than non-carriers. Serum MBL levels were significantly higher in DI-exposed subjects (including both DI-OA and AEC) carrying the GG genotype of -554 G>C and/or -225 G>C than those of other …
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The study of occupational risk factors and interventions for baker's allergy and asthma among supermarket bakery workers
… questionnaire, immunological tests (sIgE, sIgG), methacholine challenge test and fractional exhaled nitric oxide (FeNO). Exposure assessment conducted pre- and post-intervention entailed determination of inhalable concentration of particulate mass and specific allergen levels. The intervention …
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