Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 71 for “"Metastatic melanoma"”.
-
Characterizing The Role of Uchl5 In Metastatic Melanoma
<p>Metastatic melanoma is one of the most aggressive cancers. In recent years, the survival rate has improved with the introduction of immunotherapy. Our lab conducted an <em>in vivo</em> ORF screen to identify potential drivers of metastasis. UCHL5/UCH37 was identified as one of the top …
-
Photoacoustic detection of metastatic melanoma in the human circulatory system
… as an early warning system, alerting the metastatic spread or recurrence of the disease. Early detection of such cells can result in preventative treatment of the disease while late stage detection can serve as an indicator of the effectiveness of chemotherapeutics. We propose a system for …
-
MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… our group recently demonstrated that, in metastatic melanoma, BACE2 activity is deregulated and amyloid-like fibrils are secreted, altering tumor microenvironment stiffness and promoting invasive features. While investigating BACE2 role in cancer, we identified a deregulation of …
-
Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
… (CTL) frequently infiltrate tumors, yet most melanoma patients fail to undergo tumor regression. We studied the differentiation of the CD8<sup>+</sup> tumor-infiltrating lymphocytes (TIL) from 44 metastatic melanoma patients using known T-cell differentiation markers. We also compared …
-
Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy
… the tumor, we performed a multi-omic study on a metastatic melanoma cohort with RNA sequencing (39 samples), single cell RNA sequencing (222,351 cells; 39 samples), and single nucleus transposase-accessible chromatin sequencing (45,478 cells; 15 samples). We identified marker genes and functional …
-
Long-Term Survival In Metastatic Melanoma Patients With Leptomeningeal Disease Treated With Intrathecal Interleukin-2
<p><strong>BACKGROUND:</strong> Metastatic melanoma patients with leptomeningeal disease (LMD) have an extremely poor prognosis and a paucity of effective treatment options. We assessed the safety and efficacy of intrathecal interleukin-2 (IT IL-2) in metastatic melanoma patients with LMD.</p> …
-
University of Washington/Seattle Cancer Care Alliance Experience with Single Agent Ipilimumab in Advanced Unresectable/Metastatic Melanoma
… in a phase III clinical trial of patients with metastatic melanoma and was approved by the US Food and Drug Administration (FDA) in 2011. However, the response rates with ipilimumab are low (~10%) and toxicities considerable. The optimal dose and schedule still remain unclear and there is an …
-
Characterization of Skin Immune Reactions Induced by the Contact Sensitizer Diphencyprone in Healthy Volunteers and Metastatic Melanoma Patients
<p>Melanoma is a life-threatening malignant disease, of which the standard of care treatment is rapidly becoming immunologically driven, due to favorable recent clinical trials using immune checkpoint inhibitors. Diphencyprone (DPCP), a topically applied contact sensitizer, has been used with an …
-
Activating The 4-1Bb Pathway For The Expansion of Tumor-Infiltrating Lymphocytes For Adoptive T-Cell Therapy For Metastatic Melanoma Patients
… using TIL is a promising therapy for late stage melanoma patients, resulting in a 50% response rate and durable long-term survival in over 20% of patients. Current research is aiming at improving the quality of the expanded cells and their persistence <em>in vivo</em> after adoptive transfer to …
-
Characterising the effects of 1,4,5-Oxathiazinane-4,4-dioxide (OTD) on non-neoplastic cells and primary and metastatic melanoma cells in vitro
Melanoma is an aggressive form of skin cancer, responsible for the largest proportion of skin cancer related deaths in Ireland (69.4%) despite only accounting for 9% of all skin cancers leading to the development of several adjuvant therapies aiming to reduce mortality. Tissue damage inflicted by …
-
Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma
The incidence of melanoma is increasing. Immunotherapy commonly fails due to the immunosuppressive tumor microenvironment (TME). The aim of my dissertation is to develop strategies that dampen the TME’s immunosuppressive capacity and improve the antitumor performance of vaccine-induced …
-
Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… the management of several malignancies including metastatic melanoma. Although preliminary studies in patients with untreated metastatic melanoma demonstrated significantly increased progression-free survival, there is an unmet need for clinical decision-making tools that can be used for …
-
Differente Expression der Multidrug-Resistenz-Proteine 4/5 in nicht und stark metastasierenden Melanomzellen unter Hypergravitationsbedingungen
… leads to an increased cGMP efflux in non-metastatic melanoma cell lines, whereas the highly metastatic phenotype appeared to be insensitive. Biochemical analysis let assume that overexpressed MRP4, 5 and 8 could be responsible for these effects. Based on these results the aim of the …
-
Developing a Screening Process for Early Detection of Melanoma
… early signs of potentially life threatening melanoma through a simple blood test before the cancer reaches an untreatably fatal stage. There is promising data to support that such an assay is possible to determine whether a patient may have metastatic melanoma. This early detection is …
-
Optimisation of the isolation and identification of circulating melanoma cells
Although melanoma is largely curable when detected in its earliest stages, it can metastasise to other tissues, drastically reducing survival rates. The most recent therapies used to treat metastatic melanoma are effective long-term in only 11 to 33% of patients. Our ability to monitor treatment …
-
Identification of a MicroRNA Network that Regulates Melanoma Metastasis and Angiogenesis by Targeting ApoE
<p>Metastatic melanoma, a prevalent and deadly form of skin cancer, remains an aggressive clinical outcome that lacks effective preventative and/or curative therapeutics. Patients diagnosed with advanced metastatic melanoma face a dreaded 10-year survival rate of less than 10%. By performing in …
-
Mcam/Muc18 Regulates Melanoma Progression By Modulating The Expression of Id-1
The acquisition of the metastatic melanoma phenotype is associated with increased expression of the melanoma cell adhesion molecule MCAM/MUC18 (CD146). However, the mechanism by which MUC18 contributes to melanoma metastasis remains unclear. Herein, we stably silenced MUC18 expression utilizing …
-
Integrative Cancer Immunogenomic Analysis of Serial Melanoma Biopsies Reveals Correlates of Response and Resistance to Sequential Ctla-4 and Pd-1 Blockade Treatment
<p>Melanoma is the most malignant form of skin cancer. The five-year survival rate for metastatic melanoma is 19.9%. Although targeted therapy of BRAF and MEK inhibitors were developed for melanoma, resistance to therapy is inevitable. Immune checkpoint blockade, which reverses the suppression of …
-
Einfluss von Hypergravitation auf den cGMP-Efflux in Stickstoffmonoxid-stimulierten humanen Melanozyten und Melanomzellen
… isoforms in normal human melanocytes (NHM) and melanoma cell lines we used direct NO donors (NONOates) which differ in their kinetics of NO release as stimulators of sGC and ANP as a GC-A modulator. Our results demonstrate that long-term application of hypergravity (5g for 24 h) in the presence …
-
Investigation of The Functional Impact of Anti-Pd-1 On Tumor-Infiltrating Lymphocytes (Til) and Mapping of Tumor Genomic Features Relevant For Response to Til Therapy
… a 43% response rate to therapy when treating metastatic melanoma patients with adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TIL), but it is unknown what makes the other 57% of patients not respond to therapy. It is further unknown how particularly early doses of checkpoint …
Page 1 of 4