Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"Metastatic cancer"”.
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Comfort: Voices of adolescents with metastatic cancer
… experiences while undergoing treatment for metastatic cancer is limited. Expanded knowledge of how young patients explicate the meaning and significance of their comfort experience would be valuable information that would help bridge the gap in our knowledge and practice. This study explored …
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CELLULAR MRI: TRACKING THE MIGRATION OF METASTATIC CANCER CELLS IN THE LYMPHATIC SYSTEM
… of critical importance since a majority of cancer deaths result from metastatic dissemination away from the primary tumor. In the studies performed in this thesis novel cellular MRI technology and a unique murine intranodal implantation model are used to track the movement of iron-labeled …
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Targeting the actin cytoskeleton in HER2+ metastatic cancer cells using a macrolide toxin
Breast and ovarian cancers are among the leading causes of cancer related deaths in women worldwide. In a subset of these cancers, dysregulation of the human epidermal growth factor receptor 2 (HER2) leads to overexpression of the receptor on the cell surface. Previous studies have found that these …
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Cell and nanomaterial-based approaches for diagnosis and chemotherapy of metastatic cancer cells
… development is the cause of more than 90% of cancer related deaths. Therapies and diagnostics can be targeted to metastasis at three points in its progression: the primary tumor, the secondary tumor, and circulating tumor cells (CTCs). While much work has focused on primary tumors, less effort …
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Long-Term Opioid Prescribing among Patients Living with Metastatic Cancer as a Chronic Disease
Patients living with metastatic cancer often experience pain which requires involvement of palliative care and symptom management teams. Opioids are a commonly used tool for the treatment of this cancer-related pain. While opioids serve an important purpose in symptom management and end-of-life …
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Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
… as well as inducing resistance to various cancer treatments including chemotherapy, radiotherapy and immunotherapy. Mechanistic understanding of how the tumor-stromal interaction contributes to tumor progression and therapeutic resistance will advance cancer therapies and improve clinical …
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Influence of Fibroblasts on Metastatic Cancer Cell Drug Resistance in a 3D Microfluidic Cell Array
… might have on the tumor <em>in vivo.</em> In cancer therapy specifically, the outcomes of clinical treatments are heavily dependent on drug testing methods despite the cytotoxic effects these methods might have on the patient. Our lab has previously developed a three layered microfluidic cell …
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Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
… healing that is pathologically activated during cancer progression. During this process, cells undergo complex changes at the transcriptional and translational levels leading to dissolution of cell-cell junctions, loss of apical-basal polarity, and cytoskeleton reorganization. Transforming Growth …
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Detection and monitoring of treatment resistance in metastatic cancer through non-invasive DNA methylation-based biomarkers
… and disease monitoring during initial lines of metastatic treatment, represent a major challenge in ctDNA applications. Despite several approaches for ctDNA analysis have been developed in the last decade, tumor tissue agnostic detection and quantification of ctDNA in low tumor content (TC) …
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The perceived barriers to exercise and physical activity for individuals with metastatic cancer undergoing chemotherapy: a qualitative exploration
… of Life (QoL) benefits for individuals with metastatic cancer. What is less known are the formal barriers that inhibit participation within this population. This study was a qualitative exploration that investigated the barriers to exercise and PA for individuals with metastatic cancer who …
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Preparedness for end-of-life in patients with advanced metastatic cancer enrolled in a clinical trial (phase I/phase II)
Patients with advanced metastatic cancer enrolled in a phase I clinical trial have a life expectancy of less than nine months. Advance care planning (ACP) is a means of tailoring care to patients’ needs, especially at the end-of-life (EOL). An extensive review of literature identified a positive …
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Genome sequencing and phenotypic analysis of single cells in cancer
Relatively little is known about metastatic cancer. The vast majority of cancer genome profiling (~99%) is done on primary tumors; yet, metastatic cancer is attributed to >90% of cancer-related deaths. The underlying challenge is that metastatic cancer is difficult to sample: surgical resections …
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Developing C–H bond Functionalization, Organocatalytic Hydrophosphination Reactions and Anti-Invasion Agents
… anti-invasion agents for the treatment of metastatic cancer. Metastasis remains the leading cause of anti-cancer treatment therapy and cancer-related death. The rapid spread and mutation of the cancerous cells complicates treatment and increases the chance of recurrence. Treatment options …
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ΔΙΕΡΕΥΝΗΣΗ ΤΟΥ ΡΟΛΟΥ ΤΟΥ ΕΙΔΙΚΟΥ ΠΡΟΣΤΑΤΙΚΟΥ ΑΝΤΙΓΟΝΟΥ (PSA) ΣΤΗΝ ΠΑΘΟΛΟΓΙΑ ΤΟΥ ΠΡΟΣΤΑΤΗ
… SPECIFIC ANTIGEN (PSA) FROM 135 MEN (55 PROSTATE CANCER, 39 BENIGN PROSTATE HYPERTROPHY, 9 PROSTATITIS, 32 NORMAL). PSA IS A SPECIFIC-CELL TYPE ANTIGEN OF PROSTATE AND IS MORE SENSITIVE MARKER THAN PROSTATE ACID PHOSPHATASE (PAP)-71% TO 27,3%. PSA CAN NOT SOLVE THE PROBLEM OF PRIMARY DIAGNOSIS OF …
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Computational Modeling and Validation of the Deformation and Failure Response of Human Metastatic Vertebrae
Metastatic cancer, the spread of cancer cells from the primary cancer site, is responsible for many cancer-related complications and deaths. Particularly, metastatic cancer affecting the vertebra leads to the degradation of bone quality and architecture, which weakens the vertebra's load carrying …
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Ultrahigh resolution optical coherence tomography for the detection of early stage neoplastic pathologies
… outcome because advanced disease, such as metastatic cancer, can be difficult to impossible to cure. Many existing diagnostic modalities, including x-ray imaging, magnetic resonance imaging, ultrasound, and endoscopy do not have sufficient resolution to detect changes in architectural …
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Risk Factors and Epidemiologic Characteristics of Post Procedural Acute Kidney Injury in Patients from the National Surgical Quality Improvement Program (ACS NSQIP) Participant Use Data File (PUF), 2014
… CHF, male gender, hypertension, preoperative metastatic cancer, dyspnea, diabetes, smoking, COPD, open management of the wounds, non-elective, and emergent operation were the risk factors for post procedural AKI across surgical specialties, as we as in general specifically. These findings will …
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Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer
Cancer diagnosis and treatment can provoke anxiety. Anxiety is accompanied by worry, which is the continual rehearsal of potential future negative consequences. Anxiety and worry in cancer patients are related to worse outcomes. However, the link between anxiety, worry and inflammation is …
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The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells
In metastatic cancer, cells must be able to migrate from their original environment, move through the blood or lymphatic system, and colonize a distant organ. Mena, a member of the Ena/VASP family of proteins, is upregulated in invasive populations of breast cancer cells. The Ena/VASP …
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Effect of renal replacement therapy on acute kidney injury in sepsis patients
… Organ Failure Assessment score, cirrhosis, and metastatic cancer had a great impact on patient outcomes. This work concludes that RRT does in fact benefit the patient outcome and dialysis is a statistically significant feature within the dataset.
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