Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 323 for “"Metastases"”.
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Liver metastases of colorectal cancer. The impact of the primary tumour on growth of metastases.
Contains fulltext : 52573.pdf (Publisher’s version ) (Open Access)
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Molecular detection of melanoma nodal metastases
… specificity for the detection of melanoma nodal metastases. A novel protocol for the efficient homogenisation of nodal tissue was developed, with clinical applicability as the objective.
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Mathematical Models of Tumors and Their Remote Metastases
… factors, or inhibitors, to keep its remote metastases from growing. Thus, we model the depleting effect of such a growth inhibitor after the removal of the primary tumor (thus removing the source) as a function of time t and distance from the original tumor r.</p> <p>It has also been shown …
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Relevance of Fgfr1 and Its Isoforms In Prostate Cancer Bone Metastases
… FGFR1 a and b increased the incidence of bone metastases (<em>P</em> = 0.00005 and <em>P</em> = 0.025 compared to controls). Accordingly, immunohistochemical analysis of castration-resistant human PCa bone metastases revealed a significant enrichment of FGFR1 expression compared with …
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Detecting prostate cancer metastases - PET/CT and the sentinel node technique
… highly dependent on the presence or absence of metastases. The available invasive and non-invasive modalities for detecting metastases are imperfect. Positron-emission tomography fused with computed tomography (PET/CT) is a non-invasive method for detecting metastases that is presently evaluated …
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Tumor metastases of the vertebral column: diagnostic and prognostic assessments for treatment
Spinal tumor metastases are secondary tumors in the bone of the vertebral column that arise from primary cancers from other areas of the body. Metastatic neoplasms in the spine have significant implications for the overall quality of life of patients with all cancer types. Bone is one of the most …
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Metabolic Adaptations of Ovarian Cancer Metastases to Physiological Conditions and Disease Progression
Ovarian cancer is the fifth leading cause of all cancer deaths in women and the most lethal gynecologic cancer in the United States. During metastasis, cancer cells exfoliate from the primary tumor and aggregate to form spheroids, enhancing their survival within the peritoneal cavity during …
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OXIDATIVE PHOSPHORYLATION IN MELANOMA BRAIN METASTASES: A REGULATOR of THE TUMOR IMMUNE LANDSCAPE
… and immune regulation of melanoma brain metastases (MBMs).</strong></p> <p><strong> </strong>The functional significance of OXPHOS was assessed through genetic inhibition, involving knockout (KO) of key regulatory genes such as <em>Ppargc1a </em>(PGC1a) and <em>Ndfus4 </em>(NDUFS4), a …
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Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
<p>Melanoma brain metastases (MBMs) are diagnosed in up to 60% of metastatic melanoma patients. Previous studies have identified clinical factors that correlate with overall survival (OS) after MBM diagnosis. However, molecular and immune features associated with OS are poorly understood. An …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… analysis of clinical samples that melanoma brain metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including <em>PPARGC1A</em> or <em>PGC1α</em>) than patient-matched extracranial metastases (ECMs). <strong>Thus, the central hypothesis of this dissertation is …
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A Theoretical Model Of Breast Tumor Metastases In The Context Of Tumor Dormancy
Metastasis is responsible for most breast cancer deaths and currently considered as a late event in the primary tumor process. Recent evidence suggests that tumor cells dissemination may occur when the tumor is at a size that does not normally warrant a systemic treatment. Current breast cancer …
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Improved Target Coverage of Spinal Metastases Through The Use of Flattening Filter Free Beams
… up to 40% will develop vertebral osseous metastases. These metastases tend to be located in close proximity to the spinal cord itself, making it difficult to achieve the recommended minimum dose of 14 Gy for single fraction SBRT or 21 Gy<sup>1</sup> for three fraction SBRT while …
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Role of TRAF2/6 in tumour growth and bone metastases associated with breast cancer
Tumour necrosis factor receptor associated factors (TRAFs) play a key role in signal transduction in mammalian cells. Several members of the TRAF family have been identified but only TRAF2 and TRAF6 are implicated in the regulation of both osteoclastic bone resorption and breast cancer. Here I …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… mice develop significantly fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we examine the interplay between liver NKT cells and NK cells in resistance to liver metastases from intraocular melanomas. NKT cell-deficient CD1d-/- mice and WT C57BL/6 mice …
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Completion Lymph Node Dissection or Observation for Melanoma Sentinel Lymph Node Metastases: A Decision Analysis
… melanoma patients with sentinel lymph node (SLN) metastases should undergo completion lymph node dissection (CLND). Background: Randomized trial results comparing CLND with observation for patients with SLN metastases are not available. Methods: We developed a Markov model to simulate the …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… deaths is tumour metastasis. The formation of metastases is a complex multistep process, involving invasion of the basal membranes and connective tissue, penetration of the blood vessel walls, invasion of the host tissue, and initiation of growth at the new location. The degradation of …
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