Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Metastable Epiallele"”.
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Epigenetic Response to Low-Dose Ionizing Radiation
… disease susceptibility due to the presence of a metastable epiallele that modulates coat color (Waterland and Jirtle 2003). Pregnant dams were whole-body exposed to one of five doses of X-ray radiation ranging from 0-10.0 cGy on gestational day 4.5. Using a phantom mouse model, the intrauterine …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
… and other similarly behaving loci, are termed metastable epialleles, or variably methylated IAPs (VM-IAPs), and are widely cited as the best examples of mammalian epigenetic inheritance. A recent screen in the C57BL/6J mouse strain identified over 100 candidate VM-IAPs providing novel insights …
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Identification and characterisation of murine metastable epialleles conferred by endogenous retroviruses
… silenced between individuals – so called ‘metastable epialleles’. The best known example is the Avy locus where an endogenous retrovirus (ERV) of the intracisternal A-particle (IAP) class was spontaneously inserted upstream of the agouti coat colour gene, resulting in variable IAP promoter …
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Variable methylation of endogenous retroviruses: epigenetic inheritance, environmental modulation, and genetic modifiers
… a naturally occurring genetically-conferred epiallele that influences neighbouring gene expression is identified and characterised. This body of work highlights the value of using VM-IAPs as a model to study TE regulation and mammalian epigenetic stochasticity, and serves as a foundation to …
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Role of Retrotransposons as a Major Source of Intra- and Inter-Individual Epigenetic Variations in the Mammalian Genome
… and LINEs only) in the mouse genome known as ‘epialleles’ which escape the repression variably even in individuals with an identical genome sequence. Using bioinformatic approaches, 143 candidate epialleles were first identified based on their promoter activity and association with active …