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Showing 1 to 12 of 12 for “"Metallothioneins"”.
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Functional Characterization of Metallothioneins in Arabidopsis and Barley
<p>Metalothioneins (MTs) are metal binding proteins that can bind metals such as Cu, Zn, and Cd but the functions of MTs in plants are largely unknown. To understand the function of MTs in Arabidopsis, T-DNA insertion mutants lacking 4 MT genes including <em>MT1a, MT2a, MT2b</em> and <em>MT3</em> …
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The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators
… in patients. In the second part, the role of metallothioneins (MTs) as immunomodulators in intestinal inflammation is investigated. We found a significantly lower mRNA and protein expression in the epithelium of unaffected tissue of Crohn’s disease patients. In vitro studies with an …
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Identification, localization and metal-catalyzed induction of specific metallothionein isoforms expressed by the adult human lens
Purpose. Metallothioneins (MT s) are a large family of proteins involved in multiple protective pathways, including binding of toxic metals and oxidative stress. Previously we detected increased expression of MT IIA in age-related human cataractous lenses. As a first step towards defining the …
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Production of Copper-Complexing Ligands in Response to Elevated Concentrations of Copper in Marine <i>Synechococcus</i> spp.
… <em>Synechococcus</em> spp. are known to produce metallothioneins (MT) in response to cadmium and zinc stress. In the present study the hypothesis that marine <em>Synechococcus</em> produce MT in response to copper was tested. Three marine <em>Synechococcus</em> spp. i.e., PCC 7001, PCC 73109, and …
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Molecular characterisation of XvRG6 and XvRF17 genes isolated from the resurrection plant Xeropyta viscosa
… by in silico analyses to belong to the family of metallothioneins, a family of metal-binding proteins. Anaylis of the XvRG6 mRNA transcript showed that the gene was not dehydration stress inducible, but was induced by ethylene, endogenous ABA, SA and JA application. In contrast, the XvRF17 mRNA …
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Genetic Profiling in Soft Tissue Sarcoma
… genes, transcription factors, histones, and metallothioneins suggests that the gene fusion variants have distinct downstream effects. In Study III, 177 STS of mixed histopathological subtypes were profiled using cDNA microarrays. Distinct gene expression patterns were identified in subtypes …
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The role of genetic alterations in the gut-joint axis of Crohn's disease and Spondyloarthropathies
… identification of new disease-modifying genes. Metallothioneins are substantially down-regulated in CD patients with colonic involvement. Furthermore, we identified a polymorphism in MTF1, a gene for the main transcriptional regulator for MT, which also was related with disease location in CD. …
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THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… mice, but not in Nrf2-null mice. Surprisingly, metallothioneins, cysteine-rich proteins that scavenge cadmium to prevent toxicity, were induced markedly in both Nrf2-null and Nrf2-enhanced mice. Thus, there are at least two distinct pathways to protect cadmium-induced toxicity: Nrf2-dependent …
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Nitric oxide reactions of bio-Inspired zinc and cobalt complexes
… interactions of NO with nitric oxide synthases, metallothioneins, and cobalamin-containing enzymes are discussed. Bioinspired small molecule models for metalloprotein active sites are introduced, and the ability of ligands to control the steric and electronic properties of coordinated metal …
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Characterization of Cu-rich aggregates in neurogenic niches of the rodent brain by X-ray fluorescence microscopy
… protein in aggregate formation remains unclear; metallothioneins may simply facilitate Cu uptake into the cell. Exposure to Mn, which is known to disrupt brain barriers, did not affect Cu concentrations for rats in either the subventricular zone or rostral migratory stream. Furthermore, the …
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Zinco, invecchiamento e sistema immunitario: effetti sull'apoptosi e sulla proliferazione dei linfociti
… stress pathogenesis. Moreover, the expression of metallothioneins (MTs), proteins well known for their zinc-binding ability and involved in many cellular processes, i.e. apoptosis, metal ions detoxification, oxidative stress, differentiation, was evaluated in total lymphocytes, in CD4+ and in CD8+ …
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Phytoextraction of heavy metal from contaminated soils using genetically modified plants
The use of plants to clean-up soils contaminated with trace elements could provide a cheap and sustainable technology for phytoremediation. The introduction of novel traits into plants that produce high levels of biomass using a transgenic approach is a promising strategy for the development of …