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Showing 1 to 2 of 2 for “"Metallothionein 3"”.
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Characterization of Cu-rich aggregates in neurogenic niches of the rodent brain by X-ray fluorescence microscopy
… increase of Cu concentrations within aggregates. Metallothionein is a sulfur-rich protein known to be critical in Cu homeostasis in astrocytes cells. Metallothionein(1,2) knockout mice exhibit lower subventricular Cu concentrations owed in part to the fact that there are about one third as many …
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Uncovering Zn2+ and Ca2+ Homeostasis and Crosstalk in Primary Hippocampal Neurons
… but not in HeLa cells. When brain-specific metallothionein (MT3) was overexpressed in HeLa cells, Ca<sup>2+</sup> influx can induce Zn<sup>2+</sup> spikes, while silencing of MT3 expression in neurons depleted the Ca<sup>2+</sup>-induced Zn<sup>2+</sup> spikes. Our results revealed that …