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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 191 for “"Metalloproteinase"”.
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Modulating metalloproteinase activity with protein nanofibrils
Matrix metalloproteinases (MMPs) belong to a family of over 20 structurally related zinc-dependent proteases. They play a crucial role in every stage of wound healing by regulating the balance between tissue synthesis and destruction. However, excessive proteolytic activity, especially of MMP9, …
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BIOSENSING OF MATRIX METALLOPROTEINASE ACTIVITY WITH CD-FREE QUANTUM DOTS
… and the ability to detect active matrix metalloproteinase (MMP) in a biosensing system, designed to identify direct biomarkers for pathological conditions, which in turn would enable early disease diagnosis and better treatment development. In this work, highly luminescent ZnSe:Mn/ZnS QDs …
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Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer
Membrane type-1 matrix metalloproteinase (MT1-MMP) is a metalloproteinase which becomes upregulated in prostate cancer and has been implicated in processes of prostate cancer metastasis. Here, we show that MT1-MMP is minimally expressed in nonmalignant primary prostate cells, moderately expressed …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matix (ECM) components during normal and pathogenic condition. Documented expression of MMPs contributes to tissue remodeling, atherosclerosis, and inflammatory diseases. MMPs are tight regulated by …
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Effect of Methamphetamine on Gingival Fibroblast Production of Matrix Metalloproteinase (MMP)-2 and -9 and Tissue Inhibitor of Metalloproteinase (TIMP)-1 and -2 In Vitro
… by rampant caries and periodontitis. Matrix metalloproteinases (MMPs) produced by gingival fibroblasts degrade the extracellular matrix (ECM) and play an important role in periodontitis and oral cancer metastasis. There is no information on effects of METH on fibroblast MMP production, or its …
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Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas
… ability to invade surrounding tissue. Matrix metalloproteinases are thought to contribute to the invaseive phenotype of human gliomas. Absent in normal brain, matrix metalloproteinase-1 (MMP-1) has been shown to be present in gliomas, and in particular in glioblastoma multiforme (GBM). To …
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Synthesis and characterization of matrix metalloproteinase sensitive hydrogels for articular cartilage engineering
… fumarate), developed in our laboratory. A matrix metalloproteinase sensitive peptide was used to crosslink the macromer, allowing for enzymatic degradation of the hydrogel and providing more void space for the production and deposition of extracellular matrix. Various formulations of OPF and …
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The Expression of Matrix Metalloproteinase-9 and -2 in Olfactory Injury and Recovery
… olfactory bulb (OB) remain unknown. The matrix metalloproteinases (MMPs) are important components in many central nervous system (CNS) injury paradigms, yet remain unexplored in olfactory injury and recovery. To address the role of MMPs, the temporal expressions of MMP-9 and MMP-2 were examined …
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Investigation of the functions of Matrix Metalloproteinase-8 (MMP-8) in Mammary Carcinoma Cells
… cancer require better understanding. The matrix metalloproteinases (MMPs) are a family of proteases thought to promote metastasis due to their matrix degradation capabilities. MMP-8 however has been discovered to be anti-tumourigenic in many cancers, and anti-metastatic in breast cancer. This …
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Extracellular Matrix Metalloproteinase Inducer (Emmprin) Regulates Matrix Metalloproteinases in Human and Baboon Uterine Endometrium
Human epithelial endometrial cells secreted a full-length functional form of EMMPRIN that stimulated stromal expression of MMP-1,-2 and -3 but not EMMPRIN. We also found that endogenous stromal cell expression of EMMPRIN was important but not required for MMP stimulation.
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Expression, activation, and regulation of matrix metalloproteinase 2 (MMP-2) in the bovine corpus luteum
<p>Matrix metalloproteinases (MMPs) have been postulated to be important for angiogenesis and for tissue remodeling events associated with corpus luteum (CL) development. The MMPs are mainly regulated at three levels, transcription, activation, and inhibition by endogenous tissue inhibitors of …
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Determination of the role and regulation of matrix metalloproteinase-25 during mouse secondary palate formation
… of the most common birth disorders. The matrix metalloproteinases (MMPs) are required for proper SP development, but a functional role for any one of them remains unknown. MMP-25 is a candidate MMP to have a functional role in SP formation as genetic scans of the DNA of human cleft palate …
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Tissue inhibitor of metalloproteinase-1 contributes to ovulatory dysfunction in a rat model of endometriosis
… reduced fecundity in endometriosis. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are involved in endometriosis, but both are crucial for ovulation. Endometriotic lesions produce TIMP1, upsetting the balance of MMPs and TIMPs which can affect the ovaries and other organs of …
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… of the adhesion molecule VCAM-1 and matrix metalloproteinases MMP-2 and 9 at peak of EAE in treated mice. The decrease in VCAM-1 correlates with our previous observation of decreased leukocyte rolling and adhesion to brain microvasculature. However, the reduction in MMP-2/9 expression …
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The Influence of a Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter on Glioma Biology
… for this invasive nature include the matrix metalloproteinase family. MMP-1 is a member of this family which has been well studied in many types of invasive tumors, with gliomas being an exception. We studied a single nucleotide polymorphism (SNP) in the MMP-1 promoter that may influence …
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The role of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-‐15 (ADAMTS-‐15) in Breast Cancer
… tumourigenesis and metastasis is required. Metalloproteinases were implicated as key drivers of metastasis through their ability to degrade the components of the extracellular matrix. This perspective is now superseded with evidence highlighting the involvement of metalloproteinases in an …
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A novel function of tissue inhibitor of metalloproteinase-1 as a chemoattract molecule for neural stem cells
Recently neural stem cells (NSCs) were reported to migrate to damaged brain area, such as brain tumor or ischemic region. So, we hypothesized that human glioma or ischemic tissues secreted chomoattract molecules that induce NSC migration toward that area. In present study, we reported one candidate …
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