Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"Metalloenzymes"”.
-
Structure-function relationships of metalloenzymes
Anhand der Modellsysteme [NiFe] Hydrogenase und Superoxid Reduktase wurden Struktur-Funktionsbeziehungen von Metalloenzymen, die die Umwandlung kleiner Moleküle katalysieren, mittels theoretischer und spektroskopischer Methoden analysiert. Der erste Teil dieser Arbeit ist der Charakterisierung …
-
How do metalloenzymes propagate and control chemical reactions?
… and reactions cleaving carbon-carbon bonds. Metalloenzymes, which contain a metal cofactor, are particularly adept at propagating these reactions. This thesis focuses on several metalloenzymes; each an example of a different unique reaction control strategy. Both experimental and …
-
Engineering novel tandem reactions using organometallic catalysts and metalloenzymes
… epoxidation and others. On the other hand, metalloenzymes and enzymes with bound metal centers have been investigated and engineered to catalyze reactions with organic compounds that are synthetically and industrially important. While these two fields of transition metal catalysis have grown …
-
Investigations of metalloenzymes involved in bacterial natural product biosynthesis
Just as the structures of bacterial natural products have long been a source of inspiration for new developments in drug discovery and organic synthesis, so have investigations of their biosynthetic pathways led to the discovery of countless new enzyme-catalyzed reactions that open new frontiers of …
-
Metalloenzymes required for glycan processing and morphological development in Streptomyces lividans
Streptomyces are filamentous soil-dwelling bacteria with a complex life cycle. Elucidating the signals that regulate morphological change in microbes is of fundamental importance for biotechnology applications. In the case of Streptomyces a development switch occurs with the concomitant production …
-
Engineering an oxygen storage metalloprotein into carbon dioxide and oxygen reduction metalloenzymes
Made available in DSpace on 2021-09-17T04:03:56Z (GMT). No. of bitstreams: 4 DWARAKNATH-DISSERTATION-2021.pdf: 5841120 bytes, checksum: ce2ff36f34d268a44ae248b23c61d93f (MD5) Dissertation Master Document_SD3.doc: 122368 bytes, checksum: 4309f4f0e2e18bdcfb871a2e77a38be9 (MD5) LICENSE.txt: 4217 …
-
Computational Investigation of the Catalytic and Structural Roles of Metals in Metalloenzymes
Metalloenzymes capitalize on the unique roles of metal co-factors and protein scaffolds in catalyzing crucial chemical transformations at ambient conditions with exquisite selectivity. Some metalloenzymes exploit the redox properties of metal cofactors to catalyze challenging reactions, while …
-
Polar Tris(pyrazolyl)borates for the modeling of Zinc metalloenzymes in aqueous solution
… nature in the catalytic activity of zinc metalloenzymes. The zinc complexes of novel poly(pyrazolyl)borate ligands bearing polar substituents on the 3-position of the pyrazoles were expected to contribute to this. These comprise the carboxyester substituted BpC(O)OR,Me (R = Me, Et), the …
-
Generating artificial metalloenzymes containing new-to-nature organometallic cofactors via controlled ligand exchange and microfluidic screening technologies
Artificial Metalloenzymes (ArMs) containing non-natural organometallic cofactors have commanded increasing attention for their ability to catalyse transition-metal dependent transformations with the selectivity and mild conditions associated with enzymes. This work investigates novel ArMs where an …
-
Tail-anchored Triphosphate Tunnel Metalloenzymes in Arabidopsis thaliana: An Investigation into the Molecular Mechanisms underlying their Biological Functions
The Triphosphate Tunnel Metalloenzymes (TTMs) superfamily is a group of proteins that contain a tunnel-shaped β-barrel structure, called a TTM domain. They exist in all domains of life where they act on a range of triphosphate substrates. However, the biological function of most TTM proteins is not …
-
Investigating the role of secondary coordination sphere in designed metalloenzymes and engineering protein interactions for enhanced electron transfer
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
-
Enantioselective epoxidation catalyzed by manganese-substituted human carbonic anhydrase
<p>Artificial metalloenzymes are an important class of hybrid catalysts for enantioselective, regioselective and chemoselective organic transformations. Despite several limitations associated with this type of hybrid catalysts system and their limited development relative to small molecule …
-
Magnetic properties of a diferrous-water complex and ligands for modeling the active site of MMOH
… Diiron Sites in Nature.There are a variety of metalloenzymes that have nearly identical carboxylate-bridged diiron active sites. An example is sMMOH, an enzyme that catalyzes the conversion of methane to methanol. A detailed description of the active site of sMMOH[red] is given and attempts at …
-
The crystal structure of a mutant nitrile hydratase
… et at., 2002). Nitrile hydratases (NHases) are metalloenzymes made up of α and β subunits, and exist mostly as heterotetramers (αβ)₂. They are categorized into Co-containing and Fe-containing types depending on their co-factor requirements.
-
Using myoglobin models of oxidases for mechanistic understanding of the oxygen reduction reaction
… aspects of the oxygen reduction reaction in metalloenzymes that have remained elusive. There are many pathways for the oxygen reduction reaction to take place in metalloenzymes like oxidases, but strangely, there is a high degree of variance in the active site of these enzymes. Studying the …
-
METAL COMPLEXES AND THEIR BIOLOGICAL ACTIVITY IN VIVO
… are very relevant. The significance of these metalloenzymes has spurred intensive research in recent years, with a particular focus on the synthesis of artificial metalloenzymes that mimic the catalytic processes of their natural counterparts. To achieve the goal of mimicking enzymatic …
-
Bioinspired Catalysts for Phosphoryl Transfer Reactions
… in biology and are usually catalyzed by metalloenzymes. For a number of phosphoryltransfer enzymes, including the exonuclease subunit of DNA polymerase I, a mechanism involving two metal ions and double Lewis-acid activation of the substrate, combined with leaving group stabilisation, has …
-
Bio-inspired first-row transition metal complexes for small molecule activation
… important roles in the activity and function of metalloenzymes: they can help stabilize reactive intermediates and shuttle protons or electrons over the course of enzymatic transformations. Accordingly, there have been numerous efforts to mimic these advantageous structural and functional …
-
The effect of selected colonic metabolites of polyphenols on the copper-triggered Fenton reaction and hemolysis
… within the human body. It is a component of many metalloenzymes that are crucial for the proper functioning of biochemical pathways in human cells. Copper homeostasis is tightly regulated, as both its excess and deficiency can result in serious pathophysiological conditions. When copper is present …
Page 1 of 4