Global ETD Search
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Showing 1 to 2 of 2 for “"Metalloendopeptidases"”.
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Expression and glycosylation of meprin isoforms
… A and meprin B are disulfide-linked, oligomeric metalloendopeptidases in renal brush border membranes. Meprin A contains 90-kDa subunits (α subunits) and is expressed in random-bred and some inbred strains of mice. Meprin B contains subunits of 110 kDa (β subunits) <i>in situ</i>, and the enzyme …
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Sequential Actions of VCP/p97 and the Proteasome 19S Regulatory Particle in Sterol-Accelerated, ER-Associated Degradation of HMG CoA Reductase
Accelerated endoplasmic reticulum (ER)-associated degradation (ERAD) of the cholesterol biosynthetic enzyme HMG CoA reductase results from its sterol-induced binding to ER membrane proteins called Insig-1 and Insig-2. This binding allows for subsequent ubiquitination of reductase by …