Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Metallo-beta-lactamase."”.
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Discovery and optimization of inhibitors and probes that target New Delhi metallo-[beta]-lactamase
… of β-lactam hydrolyzing enzymes, known as β-lactamases, threatens their clinical efficacy. β-lactamases typically have a conserved serine in their active site that serves as a nucleophile in hydrolysis of the β-lactam substrate. Codrugs in the form of covalent inhibitors that target this …
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Molecular basis of the evolution of new protein functions: Kemp elimination and phosphoryl transfer reactions
… the de novo designed Kemp Eliminase (KE07), the metallo-beta-lactamases NDM1 and VIM2, and the N-acyl-homoserine lactonase AiiA. Based on these studies, I was able to identify three clear phenomena that are important in molecular evolution: first, preorganization of the active sites residues is …
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Molecular basis of the evolution of new protein functions: Kemp elimination and phosphoryl transfer reactions
… the de novo designed Kemp Eliminase (KE07), the metallo-beta-lactamases NDM1 and VIM2, and the N-acyl-homoserine lactonase AiiA. Based on these studies, I was able to identify three clear phenomena that are important in molecular evolution: first, preorganization of the active sites residues is …
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Characterization of the metallo-ß-lactamase from Pseudomonas aeruginosa, IMP-1.
… in microbes are a class of enzymes known as β-lactamases. These enzymes are effective in breaking down the most commonly prescribed antibiotics at present. This work investigates two separate metallo-β-lactamase enzymes, first IMP-1, which provides antibiotic resistance to Pseudomonas …