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Showing 1 to 8 of 8 for “"Metallaphotoredox"”.
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Decarboxylative Strategies in Cobalt and Metallaphotoredox Catalysis: Approaches to Aroylation, Allylation, and Strain-Driven Reactivity
Herein, the design of distinct decarboxylative strategies to access synthetically valuable molecules is described. The primary goal has been to achieve environmentally friendly cross-coupling reactions that align with the principles of green chemistry. This was successfully achieved through the use …
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DEVELOPMENT OF BASE METAL-CATALYZED HYDROGEN TRANSFER AND CROSS-COUPLING REACTIONS
… C-heteroatom coupling reactions following the ‘metallaphotoredox’ approach exploiting readily available organic photocatalysts. Thanks to their attractive features, (cyclopentadienone)iron complexes (CICs) have been applied in several transformations. However, important limitations such as the …
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CONTINUOUS-FLOW STRATEGIES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS AND RELEVANT INTERMEDIATES
… processes. The second part describes the use of metallaphotoredox catalysis for the synthesis of tryptamine derivatives, highlighting the potential of light-driven processes to access structurally complex motifs under mild conditions. The thesis further addresses one of the major limitations of …
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EXPLORING UNPRECEDENT SYNTHETIC ROUTES FOR CHIRAL AMINO DERIVATIVES
… of levetiracetam. The thesis also explores metallaphotoredox catalysis as a powerful platform for complexity-building reactions. In particular, deoxygenative arylation strategies were applied to the synthesis of dopamine-like compounds, both in batch and continuous-flow conditions, …
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Mechanistic Studies and Rational Catalyst Design of Nickel/Photoredox Dual-Catalyzed C–C Cross-Coupling Reactions
… of the mechanistic pictures of these nickel metallaphotoredox systems, the need for more accurate computational methods, readily available and user-friendly dynamics simulation tools, and data-driven approaches is clear in order to understand at the molecular level of these transformations.
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DEVELOPMENT OF PRECIOUS METAL-FREE, LIGHT-ENABLED SYNTHETIC METHODOLOGIES
… methodology. At the same time, a “metallaphotoredox” C-O and C-N cross-coupling methodology has been developed combining a base metal (nickel) with donor-acceptor cyanoarene photocatalysts. Moreover, my work demonstrated that the D-A cyanoarenes can be conveniently incorporated into …
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FROM BATCH TO FLOW: RETHINK THE WAY OF DOING CHEMISTRY
… of photochemistry. First, we examine the use of metallaphotoredox chemistry to perform cross coupling reaction, then the importance of tryptamine is discussed, pointing out current synthetic challenges and the absence of photochemical methodologies for this transformation. In the fourth chapter, …
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Light-Mediated Dual Catalysis for C–N Bond Formation
The advent of dual catalysis for organic synthesis, involving the implementation of two catalytic species in a single reaction process, has allowed new streamlined and efficient synthetic methods to be developed. This thesis describes efforts towards the development of novel transformations for …