Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 212 for “"Metagenomics"”.
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Genomics, Metagenomics and Phylogenomics of Cyanobacteria
This PhD thesis concerns the genomics, metagenomics and phylogenomics of Cyanobacteria. It is composed of five main parts, of which four are result manuscripts. In the first part (i.e., Introduction), I review a decade of cyanobacterial phylogeny and molecular dating. I show that, in spite of a …
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Viral metagenomics and phylogenomics for One Health
… these results show how the integration of viral metagenomics and phylogenomics in One Health is essential to answer fundamental questions about the diversity of viruses and how they spread and evolve. Furthermore, the methods and protocols developed in these studies can be applied to similar …
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Shotgun metagenomics exploration of fermented food microbiomes
… from various parts of the world using shotgun metagenomics. These 58 foods consist of a wide range of products, many of which have seen a recent resurgence in popularity, due to the emerging importance of the human microbiome and health. Many of these foods have not been investigated using …
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Shotgun metagenomics-based exploration of kefir microbiomes
… can provide. Chapter 2 is focused on the shotgun metagenomics-based analysis of 256 kefir milk samples produced from milk kefir grains sourced from various parts of the world. This chapter provides considerable insight into the heterogeneity of these populations, while also uncovering conserved …
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Microbiome and Metagenomics: Statistical Methods, Computation and Applications
Human microbial communities are associated with many human diseases such as obesity, diabetes and inflammatory bowel disease. High-throughput sequencing technology has been widely used to profile the microbial communities in order to understand their impact on human health. In the first part of …
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Comparative Gene-Centric Metagenomics of the Rumen Microbiome
The complex microbiome of the rumen functions as an exceptionally effective system for the conversion of plant cell wall biomass to microbial protein, short chain fatty acids, and gases including hydrogen and methane. As such, it provides a unique genetic resource for plant cell wall degrading …
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Bacterial Plant Pathogen Identification using Genomics and Metagenomics
The timely identification of pathogens responsible for disease outbreaks is crucial for implementing effective control measures and minimizing the spread of infectious diseases. Conventional methods of identification are limited to specific pathogen species because they require prior knowledge and …
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The Application of Functional Metagenomics to Natural Products Research
… currently in use (collectively termed "metagenomics"), the strategies of functional metagenomics provide access to important functions, phenotypes and activities encoded on fragments of environmental DNA (eDNA) as evidenced by the expression of these traits in model cultured bacterial …
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Metagenomics-Based Environmental Monitoring of Antibiotic Resistance: Towards Standardization
… Maria demonstrated the effectiveness of metagenomics in defining direct impact of anthropogenic stress and human fecal contamination on the proliferation of ARGs in riverine systems. The contribution of treated wastewater effluents to the dissemination of highly mobile and …
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Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
… tryptophan dimers (TDs), we have designed a metagenomics-based TD natural product discovery and development pipeline that consists of seven steps: 1) soil eDNA extraction; 2) eDNA library construction; 3) homology-based screening; 4) bioinformatics analysis; 5) heterologous expression; 6) …
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Integrative Analysis of the Human Gut Phageome Using a Metagenomics Approach
Bacteriophages (or phages; viruses that infect bacteria and archaea) profoundly influence microbial communities. Given the impact of the gut microbiome composition and function on human health, there is a growing focus on phages that inhabit the gut ecosystem. However, the extent of viral …
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Applications, complexities, and opportunities of metagenomics for clinical diagnostics and viral discovery
Metagenomic next-generation sequencing (mNGS) has transformed infectious disease research by enabling broad-range detection of microbial nucleic acids from clinical and environmental samples. However, despite its growing adoption in diagnostic and surveillance settings, substantial variability in …
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Impact of Dietary Bioactive Components in Chronic Diseases Using Nutrigenomics, Nutriepigenomics, and Metagenomics Approaches
<p>Chronic diseases that include seven of the top ten leading causes of premature deaths in the United States demand more than eighty percent of all health care cost. Although typical Western diets--high fat (HF), low fiber and low vegetables-- are frequently associated with increased risk for …
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Global meta-analysis and metagenomics approach on the soil microbiome associated with cover cropping
… effects on the soil microbial diversity, a metagenomics study was conducted. This second part of the study was to observe compositional changes in the soil microbiome in response to cover cropping and tillage. Also, this study sought to identify microbial indicators that can be used to gauge …
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Antibiotic Resistance Characterization in Human Fecal and Environmental Resistomes using Metagenomics and Machine Learning
… various environmental data types (especially metagenomics data) and present a path to advance incorporation of data analytics approaches in Environmental Science and Engineering research and applications. Chapter 3 presents a novel approach, ExtrARG, that identifies discriminatory ARGs among …
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Developing a Computational Pipeline for Detecting Multi-Functional Antibiotic Resistance Genes in Metagenomics Data
Antibiotic resistance is currently a global threat spanning clinical, environmental, and geopolitical research domains. The environment is increasingly recognized as a key node in the spread of antibiotic resistance genes (ARGs), which confer antibiotic resistance to bacteria. Detecting ARGs in the …
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Combining microbial functional metagenomics and Caenorhabditis elegans genetics to uncover and characterise novel bioactive compounds
Marine bacteria produce a wide array of biologically active metabolites involved in defence strategies and pathogenesis against a range of metazoans target organisms. In return bacteriovorous metazoans, including nematodes, have developed sophisticated strategies to neutralise or avoid such …
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