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Showing 1 to 20 of 41 for “"Metabotropic Glutamate Receptor"”.

  1. Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain

    Montana, Michael2012

    Metabotropic glutamate receptor 5: mGlu5) has been suggested to play a role in the development and maintenance of chronic pain. mGlu5 is expressed at synapses throughout the pain neuraxis where it is believed to modulate the function of ion channels that underlie nociceptive transduction and …

    wustl Repository record

  2. Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction

    Timmer, Kristin Marie2016

    … presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and nucleus accumbens (NAc), consequently facilitating drugseeking behavior. Metabotropic glutamate receptor 5 (mGluR5) has been implicated in cocaine …

    tenn-hsc Repository record

  3. Role of Medial Prefrontal Cortical Group II Metabotropic Glutamate Receptor in the Development of Cocaine Sensitization

    Xie, Xiaohu2016

    … of medial prefrontal cortical (mPFC) group II metabotropic glutamate receptors (mGluR<sub>2/3</sub>) in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR<sub>2/3</sub> receptor agonist, APDC, dose-dependently reduced acute behavioral …

    tenn-hsc Repository record

  4. Dopamine Transporter (DAT) and Metabotropic Glutamate Receptor 5 (MGLU5) Irreversible Probes for Identifying Anti-Psychostimulant Therapeutics

    Velagaleti, Ranganadh2018

    … that dopamine transporter (DAT) inhibitors and metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) possess promising anti-addiction therapeutic properties. However, the lack of human DAT (hDAT) and mGlu5 X-ray crystal structures makes it difficult to understand how …

    duquesne Repository record

  5. Investigating the dependency of metabotropic glutamate receptor 1 signaling for sustaining rapid proliferation of hemangiosarcoma cells

    Masyr, Alison ReneeUniversity of Illinois at Urbana-Champaign2022

    Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01

    uiuc Repository record

  6. THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING

    Nicodemo, Alexander A.2008

    Group I metabotropic glutamate receptors (mGluRs) - mGluRl and mGluR5 - are believed to contribute to neuronal death upon overstimulation and may be neuroprotective under other conditions. To develop treatment for mGluRs, we must identify proteins involved in their signalling. We have identified …

    uwo Repository record

  7. Role of group II metabotropic glutamate receptor subtype 2 (mGluR2) in appetitive and consummatory aspects of ethanol reinforcement

    Windisch, Kyle Allyson

    <p>Background: Group II metabotropic glutamate receptors (mGluR2/3) are predominately presynaptically located G<sub>i/o</sub> coupled receptors that are highly expressed in the cortex, nucleus accumbens, amygdala, and hippocampus. Previous studies suggest that group II mGluRs are involved in …

    purdue-thes Repository record

  8. Metabotropic glutamate receptor 5 : a therapeutic target in Fragile X and a regulator of plasticity in visual cortex

    Sidorov, Michael S. (Michael Samuel)Massachusetts Institute of Technology2014

    … Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor 5 (mGluR5) act in functional opposition to regulate local translation of synaptic mRNAs. Fragile X is the most common form of inherited intellectual disability and autism, and is expressed by a loss of FMRP. Previous …

    mit Repository record

  9. INTERACTION BETWEEN ESTROGEN RECEPTOR AND METABOTROPIC GLUTAMATE RECEPTOR 1 MEDIATES THE DUAL EFFECT OF ESTROGEN IN NEUROPROTECTION AND NEURODEGENERATION

    SPAMPINATO, SIMONA FEDERICAUniversità degli studi di Catania2011

    Estrogen receptors (ER) are known to exert important action in the central nervous system, including neuroprotection. These effects are due to interaction of estrogen with membrane localized receptors that signal through rapid transduction pathways. How membrane ERs initiate rapid signal …

    catania Repository record

  10. Dopamine Transporter (DAT), Nicotinic Acetylcholine Receptor (nAChR), and Metabotropic Glutamate Receptor 2 (mGlu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics

    Aggarwal, Shaili2018

    Numerous in vitro and in vivo studies implicate that certain ligands that interact with DAT, nAChRs, and mGlu2 have tremendous potential as anti-addiction therapeutics. However, understanding how these promising anti-addiction compounds interact with their major drug targets at the molecular level …

    duquesne Repository record

  11. Studies on the optimization of expression and purification & Functional characterization of Class C – GPCRs

    Venkata Sai Badireenath, KonkimallaUniversität Heidelberg

    G-protein coupled receptor (GPCRs) is a multigene family consisting of more than 1000 genes. They are the most abundant membrane proteins found on a cell surface and are involved in several signaling pathways. In a cell, the signal is transduced by diverse activating endogenous ligands binding on …

    heid-diss Repository record

  12. GROUP I METABOTROPIC GLUTAMATE RECEPTORS ON SELECTIVE CELLULAR SUBTYPES IN EPILEPTOGENIC MALFORMED CORTEX

    Bruch, William2017

    … model indicated an increased response to group I metabotropic glutamate receptor agonists in the region adjacent to the malformation (PMZ). In addition there was a novel response in low threshold spiking (LTS) interneurons via mGluR5 activation. To determine whether cell specific expression of …

    vcu Repository record

  13. The role of amygdala group I mGluRs in synaptic plasticity and conditioned place preference in rodents

    Kady B. SchmidtThe University of Texas Medical Branch2007

    … available. Previous studies found that group I metabotropic glutamate receptor (mGluR) antagonists can block the induction of conditioned place preference (CPP), a measure of cocaine seeking behavior, but their functions after clinically relevant withdrawal periods are not known. Our study …

    utmb Repository record

  14. Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders

    Kaplan, Eitan SMassachusetts Institute of Technology2016

    … response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs …

    mit Repository record

  15. THE GROUP II METABOTROPIC GLUTAMATE AGONIST, LY379268, DECREASES METHAMPHETAMINE SELF-ADMINISTRATION IN RATS

    Crawford, Jordan ThomasWake Forest University2011

    … there is no effective pharmacotherapy. Group II metabotropic glutamate receptor (mGluR) agonists are proposed to serve as an addiction treatment and have been shown to reduce the reinforcing properties of cocaine, but their efficacy has yet to be tested in METH. <italic>Objectives</italic>: The …

    wfu Repository record

  16. A Study on an FMRP-Mediated Translational Switch in the MGluR-Triggered Translation of Arc and Synaptic Plasticity

    Niere, Farr2012

    The group 1 metabotropic glutamate receptor (mGluR)-stimulated protein synthesis and long-term synaptic depression (mGluR-LTD) are altered in a mouse model of Fragile X Syndrome, Fmr1 knockout (KO) mouse. Fmr1 encodes the Fragile X mental retardation protein (FMRP), a dendritic RNA-binding protein …

    utswmed Repository record

  17. Regulation of mGluR7 trafficking by SUMOylatio in neurons

    최, 지희2014

    … axonal mRNA transport, channel activity, and receptorendocytosis. The metabotropic glutamate receptor type 7 (mGluR7), a presynaptic G protein-coupled receptor modulates excitatoryneurotransmission and synaptic plasticity by inhibiting neurotransmitter release. mGluR7 at Lys889 has been …

    ajou Repository record

  18. Targeting troubled translation : investigating novel therapeutic targets in mouse models of fragile X and 16p1 1.2 deletion syndrome

    Stoppel, Laura J. (Laura Jane)Massachusetts Institute of Technology2017

    … local protein synthesis via activation of metabotropic glutamate receptor 5 (mGlu₅), yet the mechanism by which mGlu₅ couples to the intracellular signaling pathways that regulate synaptic mRNA translation is poorly understood. In this dissertation, we show that manipulation of two novel …

    mit Repository record

  19. Plasticity of the pain control system induced by neuropathic pain: the amygdala-medulla system

    Gonçalves, Leonor2009

    … increased after AMY administration of a metabotropic glutamate receptor 1 and 5 (mGluR1/5) agonist and decrease after the local injection of a metabotropic glutamate receptor 1 (mGluR1) antagonist. The AMY administration of an mGluR1/5 agonist has also induced an increase in the discharge …

    minho-thes Repository record

  20. Orbitofrontal Cortex and Social Processing in Rodent Models

    Andrews, Katharine DiAnn2019

    … to social processing. Measuring GABA and Glutamate-related gene expression in OFC of mbTBI or sham-exposed rat brain revealed specific elevations of metabotropic glutamate receptor type 1 and 5 (mGluR1/5) expression in mbTBI but not sham OFC. Exposure-naïve rats intracranially injected …

    iupui Repository record

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