Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 388 for “"Metabolomics"”.
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Microfluidic tools for metabolomics
A primary challenge in embryology is to understand the factors that govern the development of preimplantation (PI) embryos and how these factors relate to embryo viability in the field of in vitro fertilization (IVF). This is particularly important as clinical policy moving towards single embryo …
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Imputing metabolomics with graph denoising autoencoders
The student, Kowshika Sarker, accepted the attached license on 2024-12-06 at 19:10.
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Quantitative genetics and metabolomics of aerobic metabolism
The quantitative genetic, biochemical, and physiological bases of variation in maximal aerobic metabolic rate (MMR) are important for understanding exercise physiology and the evolution of aerobic performance, but they still are not well understood. To this end, I studied three aspects of MMR. …
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Comprehensive Profiling of Dietary Responses Through Metabolomics
… the loss of health and onset of serious disease. Metabolomics technologies, including mass spectrometry, enables large-scale and comprehensive analysis of the complex changes in the metabolome. This systems biological approach presents an instantaneous snapshot of the physiological status of an …
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Capillary Electrophoretic Technologies for Single Cell Metabolomics
Understanding the functioning of the brain is hindered by a lack of knowledge of the full complement of neurotransmitters and neuromodulatory compounds. Single cell measurements aid in the discovery of neurotransmitters used by small subsets of neurons that would be diluted below detection limits …
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Metabolomics of desiccation tolerance in Xerophyta humilis
Resurrection plants are unique in the ability to survive near complete water loss in vegetative tissues without loss of viability. In order to do so, they employ multifaceted strategies which include structural adaptations, antioxidant and photoprotective mechanisms, and the accumulation of …
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Using Random Forest in the field of metabolomics
Metabolomics is the science of comprehensive evaluation of changes in the metabolome with a goal to elucidate underlying biological mechanisms of a living system. There is an opinion in the field of metabolomics, the study of the set of metabolites present within an organism, cell, or tissue, that …
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Metabolomics of Mammalian and Cellular Models of Aging
… report changes in the both global and targeted metabolomics (the study of small molecules) in the brains of the Ts65Dn mouse. We also report that long-term treatment with microencapsulated dietary rapamycin changes the metabolomic profiles in a manner consistent with increases in healthspan.</p> …
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Large-scale storage, analysis and integration of metabolomics data
… and experimental methods in the field of metabolomics lead to rapidly increased amounts of data originating from different sources. These large amounts of data introduce a challenge on large scale metabolomic analytics as current computational methods have reached their limits on the …
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Metabolomics and chemical library screening for antibacterial drug discovery
There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; however, they play important roles in many biological systems and processes. Amino …
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The application of metabolomics in human health and disease
Metabolomics remains one of the rapidly growing tools for the identification of new disease diagnostic biomarkers. Mass spectrometry (MS) coupled to a liquid chromatographic (LC) system and nuclear magnetic resonance (NMR) are the two major analytical plaforms currently employed in metabolomic …
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Exploring metabolomics through NMR: from early life to aging
Metabolomics occupies a unique yet demanding position in translational research. Its proximity to phenotype and its sensitivity to clinical and environmental perturbations make it a powerful tool for understanding biological processes in real-world settings. At the same time, this very sensitivity …
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POST-MORTEM INTERVAL ESTIMATION THROUGH METABOLOMICS OF PINEAL GLAND
This study investigates metabolomic profiling of post-mortem pineal glands using 1H-NMR spectroscopy. Significant diurnal variations in metabolites correlated with the post-mortem interval, offering a novel approach for time-of-death estimation.
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Chemometrics and NMR spectroscopy for metabolomics analysis of neurological disorders
Contains fulltext : 94175.pdf (Publisher’s version ) (Open Access)
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A metabolomics investigation of in utero antiretroviral exposure to neonates
This thesis, with the title "A metabolomics investigation of in utero antiretroviral exposure to neonates", deals with the concern over adverse metabolic consequences reported for some neonates prenatally exposed to antiretroviral treatment (HIV-ART). The pandemic due to HIV infection, the cause of …
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
… advances made toward the application of urinary metabolomics to cancer biomarker discovery. The term urinary metabolomics here refers to the investigation of small metabolites in urine as potential disease biomarkers. The advantage of using this approach lies in its noninvasive sampling …
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Gut microbes and serum metabolomics in canine with diabetes mellitus
Enteric microbial dysbiosis contributes to the pathobiology of canine diabetes mellitus (DM) in several ways, including interference with the host metabolism, promotion of inflammation, and altered incretin hormone responses. Enriching and diversifying an unbalanced gastrointestinal (GI) microbiome …
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Computational methods for integrating metabolomics data with metabolic engineering strain design
… genome-scale analysis of cellular metabolites, “metabolomics”, provides data ideal for applications in metabolic engineering. However, many of the computational tools for strain design are built around Flux Balance Analysis (FBA) and were developed using assumptions that preclude direct …
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