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Showing 1 to 20 of 31 for “"Metabolomic Profiling"”.
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Metabolomic profiling of C4 grass responses to environmental stress
Made available in DSpace on 2020-08-26T23:51:25Z (GMT). No. of bitstreams: 4 WEDOW-DISSERTATION-2020.pdf: 2254191 bytes, checksum: 70fd380d7e3af29dde4932af185c7e5f (MD5) Supplemental Files.zip: 267027 bytes, checksum: e8fd73338d6bf5cbd1d0c0b0a9f857f6 (MD5) LICENSE.txt: 4210 bytes, checksum: …
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Metabolomic profiling to investigate effect of curcumin in lung cancer
… The objective of this study was to use the metabolomic approach to investigate early potential biomarkers for lung cancer. Golden Syrian hamsters were randomized into two groups (treatment and control). Lung cancer was induced in treatment group by a chemical carcinogen, …
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Discovering the biological and clinical implications of modulating glucocorticoid action using metabolomic profiling of human plasma samples
… spectrometry wasthen employed for the metabolomic profiling of all the plasma samples, andMzMatch software was used to identify the metabolites present. Multivariate andunivariate analyses were employed to determine the most reliable metabolites asbiomarkers for glucocorticoid …
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An exploration of the mechanism of hydrophilic interaction chromatography (HILIC) and the application of HILIC in metabolomic profiling
… (HILIC) and its application to metabolic profiling. The effect of different mobile phase modifiers on the retention behaviour of acidic and neutral test probes was studied on silica gel based columns which confirmed the hypothesis that HILIC is due to a combination of hydrophilic …
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Targeted and untargeted metabolomic profiling of human serum, urine and brain by liquid chromatography mass spectrometry (LC-MS)
… study to apply, and in some cases develop, metabolomic profiling methods based on LC-HRMS for application to different human biofluid and tissue samples.;In the first study concerns the potential of metabolic changes to give an indication of physical fitness. Urine samples were collected …
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Comparative metabolomic profiling of phenolics in the desiccation-tolerant “resurrection plant” Myrothamnus flabellifolia (Myrothamnaceae) using conventional and green chemistry-based solvent systems
… mass spectrometry (LC-MS/MS) metabolomics approach was used to screen for phenolic compounds, including anthocyanins, from leaf material sampled in the field from eight populations representing the western, southern, and eastern range of the species distribution. Putative …
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Applications of LC-MS metabolomic profiling in inflammatory bowel disease and the development of derivatisation methods to enhance selective detection of certain compound classes
… classes of urine samples on the basis of their metabolomic profiles by modelling with data using orthogonal partial least squares analysis (OPLSDA). A number of metabolites were found to vary between the three groups although the models for separation were weak. The OPLSDA models of the saliva …
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Improving Mass Spectrometry-Based Metabolite Identification and Quantification and Application to Cardiovascular Disease
<p>High-throughput molecular profiling is being increasingly applied to identify novel biomarkers and mechanisms of health and disease. One such application is the use of mass spectrometry-based metabolomic profiling in cardiovascular disease (CVD), whose underlying pathophysiology and risk …
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POST-MORTEM INTERVAL ESTIMATION THROUGH METABOLOMICS OF PINEAL GLAND
This study investigates metabolomic profiling of post-mortem pineal glands using 1H-NMR spectroscopy. Significant diurnal variations in metabolites correlated with the post-mortem interval, offering a novel approach for time-of-death estimation.
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Common 'Inborn Errors' of Metabolism in the General Population
… rare disease. Advances in genetic and metabolic profiling at an epidemiological scale now provide an opportunity to systematically identify such examples in the population and characterise their downstream effects on health. To assess the value of untargeted metabolomic profiling for the study of …
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Metabolomic Biomarkers for Colorectal Cancer
… improve the outcome of these patients. Metabolomic profiling, as a method for describing metabolic state and alterations in the molecular constituents and capable of yielding unique and invaluable information about tumor biology, has been employed. Using a range of spectroscopy and mass …
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Microbial, metabolic and molecular determinants of neonatal mortality in the rural areas of Limpopo Province, South Africa: umblical cord blood metabolomic profile and bacterial anaysis and their association with perinatal complications
… poorly understood. Interestingly, microbial and metabolomic approaches have emerged as effective techniques for the early detection and identification of biomarkers for microbial infections and perinatal complications, shedding more light on understanding the underlying molecular mechanisms of …
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Comprehensive evaluation of cow dung digestate composition for potential soil fertilization: Advanced analytical techniques
… composition, volatile organic compounds, and metabolomic profiles. Multivariate data analysis provided a comprehensive assessment of nutrient interactions and biochemical complexity. Results indicate that CDD maintains a moisture content of 45.95%–48.72% and an alkaline pH range of 7.73–8.62, …
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Cellular and Organismal Ramifications of de novo Purine Synthesis Dysregulation
… In this body of work, I use transcriptomic profiling techniques to provide cellular and organismal process characterization of a novel cellular model of <em>de novo</em> purine deficiency in three CRISPR generated HeLa cell lines. I examine the <em>de novo</em>purine synthesis enzymes ADSL, …
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The Contextual Roles of Isocitrate Dehydrogenase-1 and Isocitrate Dehydrogenase-2 in Electron Transport Chain Complex III Deficiency
… in order to model deficiency of this protein. Metabolomic profiling of the patient's plasma and UQCRC2 KO cell lines demonstrated strong overlap, including some abnormalities broadly characteristic of ETC defects and others that may be more specific for ETCIII defects. UQCRC2-deficient cells …
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COMBINATORIAL EFFECTS OF DIET-MICROBIOTA INTERACTIONS ON HOST METABOLISM
… of body weight. Through integrated microbial and metabolomic profiling, Dubosiella newyorkensis was identified as a key driver of glucose intolerance in a lipid-dependent manner. Its human homologue, Clostridium innocuum, similarly promoted glucose dysregulation and was enriched in individuals …
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Systems-Level Analysis of Rootstock–Scion Interactions in Apple Reveals Mechanisms of Cold Tolerance Under Field Frost Events
… we integrated RNA sequencing, untargeted metabolomics, and soluble sugar profiling across floral buds ('Gala'), scion leaves ('Gala'), and rootstock sucker leaves (B.9, M.26), sampled 12 hours before and 6 hours after a naturally occurring frost in April 2021. Transcriptomic analysis …
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Novel Serum Biomarkers For Lung Cancer Early Diagnosis and Clinical Outcome
… early detection. We first performed global metabolomic profiling followed by targeted validation of individual metabolites in a case-control design of 386 lung cancer cases and 193 matched controls. We then validated the most significant metabolite bilirubin as a risk marker for lung cancer …
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Physiological and Molecular Responses of Eurythermal and Stenothermal Populations of <i>Zostera Marina</i> L (Eelgrass) to Climate Change
… presence of high CO<sub>2</sub> concentrations. Metabolomic profiling revealed differences among CO<sub>2</sub> treatments and eelgrass populations. CO<sub>2</sub> enrichment increased the abundance of Calvin Cycle and nitrogen assimilation metabolites while suppressing the abundance of …
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