Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Metabolic state"”.
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Linking genetic regulation and the metabolic state
… of high-throughput probing of cellular states have dramatically increased our ability to understand cellular compensation to perturbation. As such, integrating system-wide measurements (e.g. gene expression) with networks of protein-protein interactions and transcription factor binding …
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Quantifying pelagic primary production and respiration via an automated in-situ incubation system
… estimates of marine primary production and metabolic state. The resulting lack of data in these systems hinders efforts in scaling and including primary production in predictive models. To bridge the gap, we developed and validated a novel automated water incubator that measures in-situ …
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Leptin Action on Dopamine Neurons: Biochemical and Behavioral Analysis
… associated with them. Additionally, the metabolic state of an animal can affect drug seeking behavior. The discovery that leptin receptor (Lepr) is expressed on dopamine neurons in the ventral tegmental area (VTA) provides a link between metabolic state and rewarding behavior. By using a …
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THE RELATIONSHIP BETWEEN BRAIN AND SYSTEMIC METABOLISM IN ALZHEIMER’S DISEASE AS ASSESSED BY DUAL-TRACER ACETOACETATE/FLUORODEOXYGLUCOSE PET IMAGING
… an estimated 5.4 million people in the United States. Cerebral metabolic dysfunction is a well-established feature of AD. Despite an established relationship between systemic metabolic disease and AD we know very little about how brain metabolism is impacted in diabetes or related metabolic …
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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
… in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. PGC-1α is also integral for the maintenance of muscle mass and function during atrophic conditions. Autophagy is a highly conserved proteolytic pathway responsible for the …
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Perturbation-based Control of Industrial Fed-batch Bioprocesses
… by-products. By-product formation decreases metabolic efficiency and the by-products have inhibiting effects on microbial growth and production. At high concentrations these can even halt growth completely, leading to process failure. Due to large batch-to-batch variations and the complexity …
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Axonal transport and life cycle of mitochondria in Parkinson's disease model
… organelle motility behaviors, morphology and metabolic state. Instead, loss of Parkin produced tubular and reticular mitochondria specifically in motor neuronal cell body. In addition, unlike in immortalized cells <em>in vitro</em>, Parkin-dependent mitophagy was rarely found in our mature …
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K(ATP) channel Kir62 subunit distribution differs between muscles and between fiber types in skeletal muscle
… K+ flux together allow the channel to couple the metabolic state of a cell to its membrane excitability, is important in several tissues for the maintenance of glucose homeostasis and cytoprotection. In skeletal muscle specifically, the channel has been shown to be involved in cell volume …
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High resolution metabolic flux determination using stable isotopes and mass spectrometry
… are transcribed to proteins, which catalyze metabolic pathways, whose activity may in return affect gene expression. DNA microarrays allowed the measurement of the full gene expression profile under a particular set of environmental conditions and genetic backgrounds. To understand, however, …
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MFSD7C is an ATP Transporter that Supports Bacterial Killing by Alveolar Macrophages in a Lipid-Rich Microenvironment
… This is demonstrated to be due to their altered metabolic state, characterized by heightened glycolysis and reduced lipid oxidation. When Mfsd7c-deficient alveolar macrophages encounter bacteria with glucose available as a nutrient, their deficiency in bacterial killing is abrogated. We then …
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Early postmortem determination of porcine meat quality using Raman spectroscopy
… as they are known to correlate with the metabolic state of the muscle, which is again closely related to the resulting meat quality. Here, the pH value was shown to be calculable from only two vibrations of the Raman spectra assigned to the terminal phosphate moiety. More accurate …
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Meeting the oxygen requirements of an isolated perfused rat liver
… can be used as organ culture platforms for metabolic, genetic and systems engineering, tissue regeneration, pharmacokinetics, organ storage and marginal donor reconditioning for transplantation. The primary requirement of such a system is that it maintain ex vivo organ function in a stable …
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Spring Forward or Fall Back? Redox State as a Determinant in Glutamate Signaling Pathways Adjusting Our Brain Clock
… phase-resetting response depends on the temporal state of the clock: during the early night, light/glutamate delays clock phase, whereas during the late night, clock phase is advanced. Key signaling elements downstream of glutamate have been identified as ryanodine receptor (RyR) and soluble …
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A four-cysteine zinc finger in carboxyltransferase structurally links the functions of enzymatic activity and negative feedback regulation of translation
… of carboxyltransferase in response to the metabolic state of the cell. Comparison of experimental and simulation results validate the model while also suggesting a more complex mechanism of carboxyltransferase translational regulation not captured by the current model.
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Microscale controlled continuous cell culture
Measurements of metabolic and cellular activity through substrate and product interactions are highly dependent on environmental conditions and cellular metabolic state. For such experiments to be feasible, continuous cultures are utilized to ensure consistent conditions. However, since medium must …
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Modulation of Hepatic Lipid Metabolism by Dietary Fats in Neonatal Pigs: Implications for Steatotic Liver Disease
… influences the onset, progression, and metabolic regulation in SLD. In Study Ia, we demonstrated that steatosis develops as early as day 7 in pigs fed medium-chain fatty acid (MCFA)-rich formulas and rapidly progresses to steatohepatitis by day 14, independent of whole-body adiposity. In …
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Enhancing Metabolism of Donor Hearts for Cardiac Transplantation
… quantified using load-independent technique, and metabolic state was measured using magnetic resonance spectroscopy to define substrate utilization parameters. An inherent limitation to transplanting hearts, especially those stored for long intervals, is predicting the suitability of the organ …
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Restriction of Food Intake by Dorsomedial Hypothalamus
… intake can restrain food intake independent of metabolic state. This finding has potential implications for an understanding of binge eating and other nutritional disorders.</p>
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Characterizing the Nuclear Function of the Cell Adhesion Molecule Fat and Chromatin Regulation by the Inner Nuclear Membrane Protein Speg
… to regulate mitochondrial function and metabolic state. However, the coordination of Ft’s functions remains largely unknown. In the first part of my thesis, I present surprising results suggesting that Ft can be cleaved to release an intracellular fragment, which translocates into the …
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Enhanced Portability and Anti-Frosting Functionality of Cryostats for Synchrotron-Based X-ray Imaging
… of radiolysis and preserve samples in their metabolic state during X-ray imaging is to keep them cryogenically frozen. We have developed affordable cryostats and novel protocol to not only improve cryo-imaging at current third-generation synchrotrons, but also enable cryo-imaging at existing …
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