Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"Metabolic phenotypes"”.
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RELATING METABOLIC PHENOTYPES TO MOVEMENT BEHAVIOR IN BROOK TROUT
… often failing to explain the phenomenon. Metabolic phenotypes have been suggested as a possible driver for expression of different movement life histories. I investigated if metabolic phenotypes are related to movement strategies within a population of brook trout (<em>Salvelinus …
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The role of intrinsic and extrinsic factors in shaping alternative migratory tactics and metabolic phenotypes in brown trout
… to changes in the environment. Alternative phenotypes – i.e. discrete phenotypic variation – can arise from a combination of proximate and ultimate mechanisms. Proximate mechanisms reflect how environmental factors shape phenotypic variation via intermediate physiological processes, which …
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Metabolic phenotypes of infants with normal birth weight, small-for-gestational-age, or after maternal gestational diabetes mellitus
… overnutrition during early life with long-term metabolic outcomes. Those conditions are typically represented by two groups of infants in animal and human studies: infants born small-for-gestational-age (SGA; reflecting intrauterine undernutrition) and offspring of mothers with gestational …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… and predict survival, these include metabolic subtypes. An outstanding question and technical challenge is to visualize the metabolism of a tumour within its native microenvironment and understand to what extent its metabolism is driven by the microenvironment. Using isotope tracing …
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Low-Protein Meal Challenge as a Predictor for Weight Loss Success in Severe Obesity
… identify weight loss resistant and susceptible metabolic phenotypes, respectively, rely on prolonged fasting and overfeeding using whole-room calorimetry assessments, which represents a substantial barrier to the prospective implementation in routine obesity care. To establish a clinically …
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Towards precision medicine in psychiatry: investigating the contribution of cellular aging, pleiotropy and gender differences in psychiatric disorders and pharmacological response
… risk-taking propensity, telomere length and metabolic phenotypes). In the latter study we also focus on exploring gender differences in genetic determinants shared between mental disorders and metabolic phenotypes, highlighting the relevance of gender in the identification of pleiotropic loci …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
… for growth. Inhibition of growth-promoting metabolic pathways may prove to be a useful therapeutic strategy in cancer. However, neither the full breadth of cancer cell metabolic diversity, nor the complement of mechanisms by which tumor mutations elicit metabolic reprogramming, are known. We …
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Modeling cellular metabolism in multiple scales
… our description of physiological variability in metabolic phenotypes of yeast, we improved the Population FBA method to dynamically constrain a genome-wide metabolic reconstruction of S. cerevisiae using comprehensive proteomics and microarray data sets. Moreover, a genetic algorithm approach was …
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Metabolic heterogeneity in microbial populations
… how variability in the copy numbers of metabolic enzymes affects how individual cells extract nourishment from their environment and grow. We model independent microbial cells, each with their own set of enzyme copy numbers sampled from experimental distributions, and use flux balance …
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Mechanistic and Physiological Studies of the Insulin-Dependent Regulation of FOXA2
… mouse models, thereby enhancing their metabolic phenotypes. Foxa2 is activated under fasting conditions, but is inhibited by insulin signaling via PI3K/Akt in a phosphorylation-dependent manner, which results in its nuclear exclusion. However, the mechanism and relative importance of …
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… a deeper understanding of the cellular and metabolic changes that drive platinum resistance. Here, we dissect the interplay between platinum-induced genotoxic stress, type-I protein arginine methyltransferases–mediated post-translational modifications, and mitochondrial metabolic plasticity …
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Spatiotemporal Regulation of the NADP(H) Phosphatase Nocturnin
… of output genes involved in almost every metabolic pathway. Among these oscillating genes, Nocturnin (also Noct; protein name: NOC) has one of the highest amplitude rhythms at the mRNA level. Mice with a loss-of-function in Noct possess metabolic phenotypes, where they are protected from …
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Evolutionary Consequences of Metabolic Competition and Cooperation in Microbial Communities
… interaction, competition and cooperation over metabolic resources, and use a computational model that captures mechanistic detail of the genomic and metabolic basis of such interactions and yet is amenable to studying large scales of replicates and conditions. In chapter 1, I describe the …
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Examining cancer metabolism in vivo
… that are responsible for creating different metabolic dependencies, is critical to understanding the basic requirements of rapid proliferation and identifying potential therapeutic vulnerabilities. In particular, oncogene status, tissue-of-origin, cell-of-origin, and microenvironmental …
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Genetic Effects Mediated Through Epistatic Networks Onto Metabolic Traits
… to unravel the genetic architecture of multiple metabolic traits. These studies found that parent-of-origin effects are surprisingly common, and that they can be mediated by the environment. This indicates that our ability to predict variation in metabolic phenotypes from genotype alone will be …
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NOVEL ROLES FOR GRK2 IN METABOLIC HOMEOSTASIS AND SKELETAL MUSCLE PHYSIOLOGY
… of this dissertation, we report surprising novel metabolic phenotypes that arise from modulating GRK2 activity exclusively in the heart. We show that transgenic βARKct (TgβARKct) mice (cardiac specific expression of a GRK2 inhibitory peptide) are more susceptible to high-fat diet (HFD) induced …
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Evaluating metabolism in human renal cancer using novel surgical models
… increasing recognition of the pivotal roles of metabolic reprogramming in cancers. Indeed, this evidence has cumulated in the establishment of dysregulated metabolism as a contemporary hallmark of cancer. Metabolomics has been vital to define the metabolic landscape of cancers. This technique …
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Proteomic Signatures of Type 2 Diabetes and Related Metabolic Traits
… from genome via proteome to a variety of metabolic phenotypes, providing unique opportunities to better understand disease mechanisms and identify molecular signatures that can help to predict, screen for and diagnose different diseases using agnostic discovery approaches. The proteome is …
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Bioenergetic and Metabolic Signatures of Maternal Overnutrition in the Offspring Heart
… predisposition of offspring towards cardiometabolic disease, whilst hearts of mice born to obese dams exhibit hypertrophic remodelling and contractile dysfunction. Programmed alterations in mitochondrial respiratory function, substrate metabolism and oxidative stress have been implicated in …
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