Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Metabolic imaging"”.
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Learning-based tumor segmentation using metabolic imaging features
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms
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Simultaneous fMRI and metabolic imaging of the brain using spice
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01
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Investigation of metabolism in glioblastoma patient-derived xenografts using deuterium metabolic imaging
The identification of metabolic subtypes of cancer could be used to indicate prognosis and sensitivity to treatment. Conventional anatomical imaging techniques provide morphological information, such as tumour size and perfusion. However, they do not provide any information on metabolic activity, …
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Development of Nitrogen-15- and Carbon-13-Labeled Biochemical Probes for Hyperpolarized Metabolic Imaging
Pages 44-75 are misnumbered as pages 43-74, pages 76-103 are misnumbered as pages 73-100, pages 104-129 are misnumbered as pages 100-125, and pages 130-134 are misnumbered as pages 125-129.
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Detecting tumour responses to treatment using metabolic imaging with hyperpolarised [1-13C]pyruvate and 2-([18F]fluoro)-2-deoxy-D-glucose
… and are occasionally misleading. Molecular imaging targeting dysregulated metabolic pathways in tumours can facilitate earlier detection of treatment response. The aim of this study was to directly compare two metabolic imaging techniques that measure different parts of glycolysis, …
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Carbon and Deuterium MRI studies of human brain metabolism
Metabolic changes to the brain can be due to brain disease causing impaired functioning. Imaging of the metabolic processes is an emerging area of research that can allow for greater understanding of the brain disease whilst offering clinical potential for improved diagnosis. Hyperpolarized (HP) …
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Interrogating Cancer Metabolism using Novel Imaging Techniques
… of cancer cells in changing microenvironments. Metabolic changes can be interrogated using non-invasive metabolic imaging techniques, which enable the investigation of tumour metabolism in vivo and the identification of imaging biomarkers. Hyperpolarised 13C Magnetic Resonance Spectroscopic …
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Label-free Optical Approaches for the Non-invasive Assessment of Embryo Quality
… fail to improve life birth rate. Optical imaging may address this gap providing an accurate and non-invasive means of assessing embryo quality. In recent years, optical imaging has gained prominence due to its innate capacity to unravel the intricacies of biological processes with …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
… study has demonstrated the feasibility of imaging hyperpolarized <sup>13</sup>C pyruvate metabolism in ovarian cancer and has demonstrated inter and intra-tumoural metabolic heterogeneity, where metabolic differences were observed between patients and between different tumour deposits …
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… to invasive disease by harnessing a non-invasive imaging modality called hyperpolarized magnetic resonance (HP MR) metabolic imaging. HP MR increases the signal of conventional MRI by over 10,000-fold and can interrogate the dynamic metabolic flux (lactate-to-pyruvate ratio) <em>in vivo</em> in …
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A subspace approach to spectral quantification for MR spectroscopic imaging
… for magnetic resonance spectroscopic imaging (MRSI) is addressed in this thesis. We present a novel approach to solving this problem, incorporating both spatial and spectral prior information. More specifically, a new signal model is proposed which represents the spectral variations of …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… and predict survival, these include metabolic subtypes. An outstanding question and technical challenge is to visualize the metabolism of a tumour within its native microenvironment and understand to what extent its metabolism is driven by the microenvironment. Using isotope tracing …
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Advancement of 31P Magnetic Resonance Spectroscopy Using GRAPPA Reconstruction on a 3D Volume
… this research is to improve currently available metabolic imaging techniques for clinical use in monitoring and predicting treatment response to radiation therapy in liver cancer. Liver metabolism correlates with inflammatory and neoplastic liver diseases, which alter the intracellular …
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Label-free multiphoton microscopy for imaging transient metabolic dynamics in living cells and tissue
… of pathological conditions. While clinical imaging tools have emerged to probe metabolism at the tissue and organ level, the tools to probe metabolic dynamics at the cellular level have been slow to develop. This thesis represents a step toward realizing one such tool through the use of …
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Advanced parallel magnetic resonance imaging methods with applications to MR spectroscopic imaging
Parallel magnetic resonance imaging offers a framework for acceleration of conventional MRI encoding using an array of receiver coils with spatially-varying sensitivities. Novel encoding and reconstruction techniques for parallel MRI are investigated in this dissertation. The main goal is to …
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Multimodal Imaging of Inflammation at the Neurovascular Interface in Cerebrovascular Disease
… stroke. While conventional clinical imaging simply measures the degree of vessel stenosis, it is a crude measure that reveals little of the metabolic processes affecting plaque vulnerability. Our research demonstrates the utility of positron emission tomography (PET) using …
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Potential of metabolic MRI to address unmet clinical needs in localised renal cancer.
… identify the unmet needs, and propose how metabolic imaging techniques could be used to tackle these needs. This proposal was the core of my PhD research, of which results I present in Chapters 2-4, as described below. 1. Chapter 2: here I investigated the potential of hyperpolarised …
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Investigating The Metabolic Progression of Glioblastoma With Hyperpolarized Magnetic Resonance
… goal of this project was to determine whether metabolic imaging with hyperpolarized magnetic resonance spectroscopy (MRS) could detect changes in tumor progression more rapidly than conventional anatomic magnetic resonance imaging (MRI) in patient-derived GBM murine models. To comprehensively …
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Preserving hyperpolarised nuclear spin order to study cancer metabolism
… To achieve this, we are using magnetic resonance imaging (MRI), which can provide detailed physiological information with relatively high temporal and spatial resolution. In combination with the dynamic nuclear polarisation (DNP) technique, high signal-to-noise is obtained, resulting in a powerful …
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