Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Metabolic heterogeneity"”.
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Metabolic heterogeneity in microbial populations
… how variability in the copy numbers of metabolic enzymes affects how individual cells extract nourishment from their environment and grow. We model independent microbial cells, each with their own set of enzyme copy numbers sampled from experimental distributions, and use flux balance …
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A Multiplexed, Multi-scale Optical Imaging Platform to Quantify Tumor Metabolic Heterogeneity
… or treatment. It is understood that tumor heterogeneity is a driving force in tumor recurrence. Temporal heterogeneity is associated with therapeutic treatment, where the administration either selects for resistance subpopulations of tumor cells that are able to recur or a de novo resistant …
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Imaging Metabolic Signatures in High Grade Serous Ovarian Cancer
… and has demonstrated inter and intra-tumoural metabolic heterogeneity, where metabolic differences were observed between patients and between different tumour deposits within the same patient. Here I compared the use of <sup>13</sup>C magnetic resonance spectroscopic imaging (MRSI) of …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
… for growth. Inhibition of growth-promoting metabolic pathways may prove to be a useful therapeutic strategy in cancer. However, neither the full breadth of cancer cell metabolic diversity, nor the complement of mechanisms by which tumor mutations elicit metabolic reprogramming, are known. We …
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Catching a glimpse: the visualization of Mycobacterium tuberculosis from TB patient bioaerosols
… how and when Mtb is aerosolized nor the key metabolic and morphological determinants driving successful transmission. To address these knowledge gaps, my doctoral research sought to develop a microscopic method for the detection of aerosolized Mtb following liquidcapture within the …
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Clinical and biological validation of hyperpolarised MRI of prostate cancer
… and associated patient morbidity. Imaging the metabolic alterations that occur during tumour development is a promising approach for improving the diagnostic potential of MRI. Hyperpolarised [1-13C]pyruvate MRI (HP-13C-MRI) is an emerging clinical metabolic imaging technique that can probe the …
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Biochemistry in healthy and neoplastic human tissues: metabolic alteration revealed by HR-MAS nuclear magnetic resonance spectroscopy
… MRS shows high specificity in detecting the main metabolic alterations in the primitive cerebellar lesion; which consist of very high amounts of the choline-containing compounds and of very low levels of creatine derivatives and N-acetylaspartate. Ex vivo HR-MAS NMR, performed at 9.4 Tesla on the …
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Metaboloptics: In Vivo Optical Imaging to Enable Simultaneous Measurement of Glucose Uptake, Mitochondrial Membrane Potential, and Vascular Features in Cancer
… is a hallmark of almost all cancers. A tumor’s metabolic phenotype can drastically change its ability to proliferate and to survive stressors such as hypoxia or therapy. Metabolism can be used as a diagnostic marker, by differentiating neoplastic and normal tissue, and as a prognostic marker, by …