Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Metabolic function"”.
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Dietary Manipulation of Metabolic Function in the Human Gut Microbiome
… of inflammation and gastrointestinal (GI) function, and may be central to the link between host and microbiota. Supplementing the diet with microbially accessible carbohydrates, termed prebiotics, is one mechanism by which SCFA production can be augmented or altered. While prebiotic …
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The impact of maternal obesity on vascular and metabolic function throughout pregnancy.
… Using non invasive techniques microvasular function was measured at each visit. Fasting bloods were taken. This assessment allowed us to observe microvascular function, inflammatory response, dislipidaemia and changes in fatty acid composition with advancing gestation and the degree of …
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Novel drug and exercise therapies to restore metabolic function in children with severe burns
… loss in lean body mass, and impaired physical function. This stress response can extend well beyond wound healing, which can negatively impact an individual’s quality of life and their ability to reintegrate into society. Clinical and translational research in the past few decades has vastly …
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The Impact of Excess Nutrients, Fatty Acids or Glucose, on BeWo Placental Trophoblast Metabolic Function
… has been well linked with the development of metabolic health disorders in the exposed offspring. Impairments in placental development, mitochondrial respiration, and nutrient processing are thought to specifically underlie the in-utero programming of these metabolic diseases. In these …
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Determining the Effects of Water Quality on Stream Metabolic Function of Urban Stream Corridors in Columbus, Georgia
<p>Urbanization alters streams, disrupting their natural habitat and inducing changes in nutrient dynamics and primary productivity. These human-induced interventions diminish ecological structure, homogenizing once-diverse ecosystems and posing a risk of impairment or destruction. Continuous …
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Oscillations in microvascular flow : their relationship to tissue oxygenation, cellular metabolic function and their diagnostic potential for detecting skin melanoma - clinical, experimental and theoretical investigations
Tumour vasculature is known to be inefficient and abnormal due to poorly regulated angiogenesis during tumour growth. This leads to irregular patterns of blood flow which are spatially and temporally heterogeneous. Many investigations into the characteristics of tumours are invasive and performed …
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Psychological and Biological Sequelae of Exposure to Prenatal Maternal Depression: Findings from the 25-Year Prospective South London Child Development Study
… of hypothalamic-pituitary-adrenal (HPA) axis function, inflammation and metabolic function. Previous research has shown that abnormalities in all three systems are associated with exposure to prenatal maternal depression, childhood maltreatment and depressive psychopathology. <br/>Methods: The …
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Do Probiotics Protect Against the Deleterious Effects of a High-Fat Diet?
… which is associated with low-grade inflammation, metabolic dysregulation and degradation of tight-junction proteins between intestinal cells. Probiotic supplementation is the practice of ingesting live strains of bacteria that are proposed to have a beneficial effect on the host by enriching the …
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Development Of Scaffold Architectures And Heterotypic Cell Systems For Hepatocyte Transplantation
<p>In vitro assembly of functional liver tissue is needed to enable the transplantation of tissue-engineered livers. In addition, there is an increasing demand for in vitro models that replicate complex events occurring in the liver. However, tissue engineering of sizable implantable liver systems …
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Sex differences in exercise-mediated changes in diet preference and its associated cognitive and metabolic outcomes
… in females than males. However, obesity-related metabolic and cognitive dysregulation is more severe in males. One mechanism by which exercise may protect against these negative outcomes and restore energy homeostasis is through changes in macronutrient selection, specifically decreasing intake …
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Body Composition Assessment After Pediatric Liver Transplant
… growth and development due to the disruption of metabolic function. Pediatric liver transplantation generally restores metabolic function and results in growth recovery; yet, some children who have undergone liver transplant continue to be malnourished, have increased adiposity and may develop …
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Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation
… parasympathetic, inflammatory cytokines and metabolic hormones, this dissertation focuses on glucocorticoids because of the extensive regulatory role they play in mounting the adaptative response to stress. Additionally, glucocorticoids act to regulate feeding and energy balance, and when not …
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The Impact of Cardiorespiratory Fitness on Cytotoxic T Cell Function and Metabolism
… (CRF) is a key indicator of the health and function of several bodily systems, but it is unknown how CRF impacts the function of specific immune cells such as cytotoxic CD8+ T cells (Tc). Tc utilize cytokines, such as interferon-γ (IFN-γ), to orchestrate cell mediated responses to viral …
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Computational methods for functional interpretation of diverse omics data
… transcriptomic, proteomic, and metagenomic data. Functional interpretation of these data is key to elucidating the potential role of different molecular levels (e.g., genome, transcriptome, proteome, metagenome) in human health and disease. However, the massive size and heterogeneity of raw data …
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Studies on the metabolism and excretion of chlorine chloride
… the physiologist because of its role in normal metabolic function, and to the pharmacologist because of its possible application in the treatment of several human diseases.</p><p>The overall function of choline in the biologic system must be seen as an equilibrium between its lipotropic activity …
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Mechanistic and Physiological Studies of the Insulin-Dependent Regulation of FOXA2
… mouse models, thereby enhancing their metabolic phenotypes. Foxa2 is activated under fasting conditions, but is inhibited by insulin signaling via PI3K/Akt in a phosphorylation-dependent manner, which results in its nuclear exclusion. However, the mechanism and relative importance of …
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A functional analysis of growth hormone receptor promoter regions in swine
… regulating growth, development, and reproductive function in animals. GHR expression in the liver is critical for postnatal growth and is regulated by tissue-specific promoters. While promoter 1 (P1) is considered the primary hepatic promoter in species such as cattle, the role of P1 and promoter …
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Impacts of microRNAs on Skeletal Muscle Protein Synthesis and Mitochondrial Quality
… promoters and affect muscle plasticity and metabolic health. A detailed review on the generation and processing of miRNAs with a view to skeletal muscle brings up intriguing connections in the transcriptional connections between multiple miRNAs. Additionally, exciting new research has …
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Identifying The Immune Related Metabolic Properties of Pancreatic Cancer Using Nuclear Magnetic Resonance Spectroscopy and Dynamic Magnetic Resonance Spectroscopic Imaging With Hyperpolarized Pyruvate
… cancer cells exhibit a significant increase in metabolic activity relative to normal tissue, an understanding of the metabolic function of tumors in systems with different levels of immunocompetence is a critical first step to develop an understanding of the immune-related metabolic properties …
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