Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 171 for “"Metabolic changes"”.
-
Metabolic Changes in Astrocytes Following Traumatic Brain Injury
… effects, many of which occur due to functional changes in the brain after injury [2], [3]. Environmental changes within the brain after TBI are significant factors in determining functional changes and outcomes [4], [5]. It is accepted that the role of astrocytes is highly significant in the …
-
Cold-Induced Metabolic Changes in Lean, NAG-1 Transgenic Mice
<p>Obesity is a multifaceted metabolic disorder with severe worldwide public health consequences. While obesity can often be treated using diet and exercise, there are complex genetic interactions driving obesity that don’t always respond to such changes. One important research focus for addressing …
-
Obesity, 11β-hydroxysteroid dehydrogenase and metabolic changes in the pathogenesis of idiopathic intracranial hypertension
… and examined the roles of obesity, 11β-HSD1 and metabolic changes in the pathogenesis and treatment of IIH. We demonstrated that ICP regulating structures (choroid plexus and arachnoid granulation tissue), are potential glucocorticoid target tissues expressing 11β-HSD1. Metabolomic analysis …
-
Metabolic changes in cellular components of the vasculature : examining the link between diabetes and cancer
… to that of cancerous cells.First, certain metabolic alterations in cultured bovine pulmonary artery endothelial cells following treatment with metal-activated C-peptide were monitored using liquid scintillation, platereader, and microfluidic techniques. As recent reports from the Spence …
-
Understanding liver metabolic effects of estrogens and liver niche-related metabolic changes in metastatic breast cancer
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
-
Physiological and Metabolic Changes Induced by Lethal Concentrations of 2,4-Dichlorophenoxyacetic Acid in the Cocklebur (Xanthium Spp.)
Made available in DSpace on 2014-12-10T17:12:30Z (GMT). No. of bitstreams: 1 6706578.pdf: 3792209 bytes, checksum: 1ad9e763d2bb63189b74665f544af791 (MD5) Previous issue date: 1966
-
Local or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes and Downregulates c-MYC Oncoprotein
… contributes to the immune repolarization and metabolic reprogramming of tumor myeloid stroma. Additionally, we explore how STING signaling modulates myeloid cell metabolism, inducing a hypometabolic state that may be central to the STING-dependent shift from M2-like to M1-like myeloid …
-
Metabolic changes to GLUT-4 levels in urban Chacma baboons on the Cape Peninsula: raiding their way to type 2 diabetes?
The Chacma baboons (Papio ursinus) of the Cape Peninsula are established raiders of human food, leading to widespread conflict between this intelligent, adaptable species and humans. The modern Western diet that these baboons have become exposed to has many deleterious effects on health, including …
-
Effect of yacon flour (Smallanthus sonchifolius) consumption on body weight, body composition, intestinal permeability and metabolic changes in excess body weight adults
… root. The effect of yacon flour consumption on metabolic markers has not been studied in excess body weight adult humans. Thus, we evaluated the effect of the consumption of yacon flour associated with an energy restricted diet on body composition, food intake, intestinal function, biochemical …
-
Autocrine prolactin signaling in breast cancer cells leads to metabolic changes and therapeutic opportunities for anti-tumour and anti-bone metastatic treatment
Breast cancer is the most diagnosed cancer among women worldwide and is often associated with osteolytic bone metastasis, characterized by bone destruction. There is growing evidence for a role of autocrine prolactin (PRL) signalling in breast cancer progression, as well as for a role of prolactin …
-
Energetic costs of toxicant metabolism in rainbow trout ( Oncorhynchus mykiss)
… to detoxification. This study investigates the changes in energetic demands associated with increased detoxification. Two CYP1A inducers were employed, PCB-126 and BNF. Resveratrol, a documented inhibitor of CYP1A activity and gene expression, was used to correlate metabolic changes in CYP1A …
-
Carbon and Deuterium MRI studies of human brain metabolism
Metabolic changes to the brain can be due to brain disease causing impaired functioning. Imaging of the metabolic processes is an emerging area of research that can allow for greater understanding of the brain disease whilst offering clinical potential for improved diagnosis. Hyperpolarized (HP) …
-
Mitochondrial Metabolism Elucidated by Rapid Fractionation from Tissue
Mitochondria are metabolic hubs, with many diseases found to have altered metabolism and mitochondrial dysfunction, such as ischaemia-reperfusion injury. A detailed understanding of the metabolic changes in different cellular pools would aid diagnosis and treatment. However, the current methods of …
-
Integrating Genomics and Metabolomics to Inform Breeding for Powdery Mildew Resistance in Grapevine
… selection. In a follow-up study to characterize metabolic changes attributed to hap+chr2 and hap+chr15, a metabolomic experiment was conducted on whole-plant propagated grapes in a time-course response to in vivo inoculation. The use of several multivariate analyses systematically identified 52 …
-
Metabolic support in left ventricular hypertrophy
Aims: To examine the metabolic changes associated with LVH secondary to AS, to examine the role of GIK as an adjunct to myocardial protection during AVR, and to examine the mechanism of its action. Methods: 220 patients with LVH secondary to AS were randomised 1:1 to receive an infusion of GIK at …
-
Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
… PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high rates of glucose, glutamine, leucine and transferrin uptake, and expressed constitutively high levels of CD71, the transferrin receptor, and CD98, the System L amino …
-
Comprehensive Profiling of Dietary Responses Through Metabolomics
… (CVD). Much of the current understanding of the metabolic changes and dysregulation that accompanies ageing and the development of NCDs are determined by limited blood biochemical measurements, often in fasting conditions. Such measures provide little information of the dynamic metabolic …
-
In Vivo Metabolic and Vascular Response to Hypoxia in Twist Knockdown Murine Breast Cancer
… and invasiveness. It has also been linked to metabolic reprogramming and increased metastatic risk. Furthermore, metabolic preferences can increase proliferation, enhance metastatic potential, and influence the site of metastasis. We hypothesize that Twist directly affects the metabolism of …
-
The acute effects of propranolol on metabolic dysfunction in severely burned pediatric patients
… that develops after injury. This surge develops metabolic dysfunction that is categorized by significantly elevated energy mobilization through increased glucose production and lipolysis. These metabolic changes contribute to the morbidity associated with delayed recovery. Hyperglycemia, …
Page 1 of 9