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Showing 1 to 8 of 8 for “"Metabolic Vulnerability"”.

  1. Targeting a Metabolic Vulnerability in Prostate Cancer

    Affronti, Hayley; 0000-0001-9751-0629State University of New York at Buffalo2018

    Ph.D.

    buffalo Repository record

  2. Metabolic vulnerability in HER2-positive Breast Cancer

    Ding, Yi2018

    … lethal targets. TALDO1, a gene encoding a metabolic enzyme in the non-oxidative pentose phosphate pathway was identified from the screen. Metabolic profiling with isotope-labeled glucose was used to understand the mechanism. The profiling results indicated that TALDO1 was necessary for …

    duke Repository record

  3. Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia

    Saglio, Giuseppe, Houshmand, MohammadUniversità degli Studi di Torino2021

    unito Repository record

  4. Antioxidant Programs Are Essential for Enzalutamide-Resistant Prostate Cancer

    Blatt, Eliot Benjamin2025

    … to improve patient outcomes. To identify the metabolic alterations involved in enzalutamide resistance, we performed metabolomic, transcriptomic, and cistromic analyses of enzalutamide-sensitive and -resistant PCa cells, xenografts, patient-derived organoids, patient-derived explants, and …

    utswmed Repository record

  5. Therapeutic Potential of Prmt5 and Mat2A As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors

    Barekatain, Yasaman, <p>0000-0002-4454-1496</p>2024

    … lung squamous cell carcinoma. MTAP is a critical metabolic enzyme in the methionine salvage pathway responsible for the breakdown of methylthioadenosine (MTA). As a result, <em>MTAP</em>-deleted cells cannot metabolize MTA, leading to the accumulation of MTA. High levels of MTA in …

    uthsc Repository record

  6. The Identification and Targeting of Altered NAD+ Metabolism in Glioblastoma

    Chang-Gu, Bruce Kenneth 1998-The University of Texas Medical Branch at Galveston2026

    … and evaluates multiple strategies to target this vulnerability. We first performed transcriptomic analyses from The Cancer Genome Atlas and Genotype Tissue Expression database and identified multiple enzymes involved in NAD+ synthesis and consumption are upregulated in GBM compared to normal brain …

    utmb Repository record

  7. Targeting Metabolic Adaptations to Anti-Angiogenic Therapy In Ovarian Cancer

    Glassman, Deanna M, Glassman, Deanna, <p><strong>0000-0003-4591-8272</strong></p>2022

    … inhibitor as a means of exploiting the metabolic vulnerability of glutamine dependence that develops as a result of adaptive resistance to AVA therapy.</p> <p><strong>Experimental Design: </strong>We used a glutaminase inhibitor (GLSi) synthesized at MD Anderson Cancer Center for all …

    uthsc Repository record

  8. Investigating Therapeutic Strategies to Target Metabolic Vulnerabilities of Nsclc Tumors With Mutant Keap1 Gene

    Koppula, Pranavi, <p>https://orcid.org/<strong>0000-0002-7567-1891</strong></p>2021

    <p>The metabolic vulnerability of cancers has long been envisaged as an attractive window to develop novel therapeutic strategies. Metabolic flexibility at the cellular level encompasses the efficient rerouting of anabolic and catabolic pathways in response to varying environmental stimuli to …

    uthsc Repository record