Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Metabolic Rewiring"”.
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The role of metabolic rewiring in endocrine resistance
… resistance, nuclear export system, and cellular metabolic pathways, and to evaluate the metabolic impact of combinational ER and XPO1 targeting by using combination of endocrine therapy agents and a XPO1-specific small molecule inhibitor (Selinexor-SEL) in different endocrine resistant ER (+) …
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MULTI-OMICS PROFILING DECODES BACE2-DEPENDENT METABOLIC REWIRING IN METASTATIC MELANOMA
… metastatic melanoma is characterized by high metabolic plasticity, we explored the novel role of BACE2 in regulating lipid homeostasis and metabolic adaptation. By combining proteomics, metabolomics, and LiP-MS within an integrative R-based analytical framework, we characterized metabolic …
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An integrated approach to understanding the metabolic rewiring of cancer cells
… recently begun to appreciate the extent of metabolic rewiring required to sustain the uncontrolled growth of tumors. Cancer metabolism is now an active area of research, and efforts are underway to expand the range of oncology diagnostics and therapeutics through targeting metabolism. …
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… a deeper understanding of the cellular and metabolic changes that drive platinum resistance. Here, we dissect the interplay between platinum-induced genotoxic stress, type-I protein arginine methyltransferases–mediated post-translational modifications, and mitochondrial metabolic plasticity …
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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment
… of cancer cells exhibit high plasticity as many metabolic pathways and enzymes are redundant. This allows for cancer cells to adapt to the changing nutritional and intercellular context of the tumor. Though metabolic rewiring helps cancer cells survive and grow, the resultant reliance on specific …
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A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
… of cancer-related mortality worldwide, yet the metabolic mechanisms that underlie its initiation and progression remain poorly defined. Mitochondrial metabolism, particularly the function of respiratory complex I, has emerged as a key determinant of tumor bioenergetics and signaling. This …
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"Interrogating the genomic and metabolomic landscape of pseudohypoxic phaeochromocytoma and paraganglioma syndromes"
… systems has limitations[4, 5]. The discovery of metabolic rewiring of SDHx deficiency at the tumour level holds promise as a non-invasive disease biomarker. Endothelial PAS domain protein 1 (EPAS1 or HIF2A) is another pseudohypoxia-associated gene that is rarely identified in sporadic PPGLs and, …
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STUDY ON HISTONE DEACETYLASE 3 AND ITS PHARMACOLOGICAL REGULATION IN THE PATHOPHYSIOLOGY OF ADIPOSE TISSUE
… or genetic alterations of HDAC3 have shown metabolic rewiring of white adipocytes towards browning via the activation of a futile cycle of lipolysis and lipogenesis. Obesity is characterized by chronic low-grade inflammation due to secretion of pro-inflammatory cytokines by immune cells, but …
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Mitochondrial metabolism in cancer transformation and progression
Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological implications and clinical relevance are unclear. In this study, I systematically …
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ACUTE ISCHEMIC STROKE: CANCER-RELATED STROKE AND MULTIMODAL ANALYSIS OF THROMBI.
… degranulation, complement cascades, and metabolic rewiring. Integrative proteomic–transcriptomic networks identified central hubs (FN1, GAPDH, HSP90AA1, ACTB, MYH9) linking immune and stress-response modules. Conclusions These studies show how AC, its subtypes and its therapies shape AIS …
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Computational Modeling of Planktonic and Biofilm Metabolism
… description of intracellular metabolism (e.g., metabolic fluxes) of microorganisms. Therefore, in this study, I have applied computational modeling approaches (i.e., 13C assisted pathway and flux analysis, flux balance analysis, and machine learning) to both planktonic and biofilm cells for …
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… which are caused by germline mutations in metabolic enzymes and nutrient transporters, provide an opportunity to observe how discrete metabolic defects cause human disease. Glycogen Storage Disease Type 1a (GSD1a), or von Gierke's disease, is an autosomal recessive IEM caused by defects in …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… In this study, we aim to characterize the metabolic profiles of cancer persister cells mediated by cancer therapeutics, as epigenetic changes induced by drugs can lead to a transient metabolic rewiring of persister cells that can be associated with the phenotypic switch between normal and …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… CA-PSCs and PC cells undergo significant metabolic changes. A key alteration is increased expression of nutrient transporters to promote nutrient uptake. Solute carrier transporters have gained significant attention as a novel class of therapeutic targets, particularly solute carrier …
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The generation of a human cell line to elucidate the role of Fumarate Hydratase loss in cancer
… conditions. These cancer-associated metabolic changes can affect several pathways one of which is mitochondrial metabolism. The suppression of mitochondrial metabolism has been associated with poor clinical outcomes and mitochondrial dysfunction has been associated with some …
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Oncogenic KRAS drives heterogeneity in metabolic and signalling pathways through genetic and non-genetic mechanisms
… alleles might rewire cellular signalling and metabolic networks causing phenotypes and adaptation in an allelespecific manner. On the other hand, cell-to-cell variability within mutant clones might permit a population of cells to escape tumour suppressive mechanisms such as senescence and …
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Characterising the effects of 1,4,5-Oxathiazinane-4,4-dioxide (OTD) on non-neoplastic cells and primary and metastatic melanoma cells in vitro
… This response may be attributed to metabolic rewiring of melanoma cells in response to glycolytic inhibition, promoting tumour survival. Immunosuppression post-operatively results in impairment of adaptive immune responses such as anti-tumoural CD8+ T lymphocyte function. Thus, the …
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Local or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes and Downregulates c-MYC Oncoprotein
… contributes to the immune repolarization and metabolic reprogramming of tumor myeloid stroma. Additionally, we explore how STING signaling modulates myeloid cell metabolism, inducing a hypometabolic state that may be central to the STING-dependent shift from M2-like to M1-like myeloid …