Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"Metabolic Regulation"”.
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Metabolic Regulation of Cellular Signaling
… system, we have previously characterized a novel metabolic regulation of cell death. We found that glucose-6-phosphate (G6P) via the pentose phosphate pathway leads to increased nicotinamide adenine dinucleotide phosphate (NADPH) levels, a subsequent increase in cytosolic acetyl-coenzyme A and …
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The dynamics of metabolic regulation
… complex network of biochemical reactions, whose regulation enables living cells to cope with variable environments and perturbations. Since metabolic regulation occurs at multiple time scales and involves diverse molecular mechanisms, understanding and manipulating the dynamics of metabolism in …
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Metabolic Regulation of Circadian Timekeeping
… of the relative flux through early primary metabolic pathways. This is accompanied by the development and optimisation of a microfluidic system for long-term perfused tissue culture, which allows for longitudinal study of metabolic flux within the same population of cells with simultaneous …
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Metabolic Regulation of Mast Cell Regranulation
… Thus, MC regranulation is regulated by a metabolic reprogramming that requires the interaction of the glucose-6-phosphate transporter Slc37a2 and the nutrient sensor mTORC1. </p>
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Metabolic Regulation by Fibroblast Growth Factor 21
… is expressed in liver and contributes to the regulation of adipose tissue and hepatic ketogenesis during the fasted state. Using in vitro and in vivo methods to investigate the effects of FGF21, a model whereby FGF21 stimulates lipolysis in adipose tissue was generated. Intriguingly, using our …
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Metabolic Regulation of Protein Phosphorylation and Acetylation
Pages i-xviii are misnumbered in a variety of ways.
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Metabolic regulation of trained immunity in atherosclerosis
Contains fulltext : 250459.pdf (Publisher’s version ) (Open Access)
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Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
… Responds to extracellular information requires metabolic alterations and differential gene expression. Recently emerging concept of metabolic regulation of transcription reveals that fluctuation of metabolite levels could modulate the activities of enzymes involved in gene regulation, which …
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Molecular and Metabolic Regulation of Gastrointestinal Cancer Metastasis
<p>Most of the cancer related mortality caused by metastatic disease rather than primary tumor growth. More than 80% of gastrointestinal cancers initially metastasize to the liver first. While the prognosis of early-stage cancers is improving, a significant proportion of patients have metastatic …
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Metabolic regulation of mammalian cell growth and proliferation
… by environmental factors that influence how the metabolic network is used. This dissertation examines how cells regulate their biosynthesis to enable coordinated growth and division, and how metabolic dependencies impact proliferation. We first investigated why cells that genetically upregulate …
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UNDERSTANDING THE MOLECULAR MECHANISM LINKING ATM TO METABOLIC REGULATION.
… in A-T cells. In addition, we identified a metabolic regulator as a major driver of glycolysis impairment and poor cell growth in A-T tissues. Respectively, the downregulation and inactivation of this metabolic regulator in A-T cells restored normal glycolysis, reduced metabolites …
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Metabolic regulation of human vascular endothelial cell function in vitro
… and AMP-dependent kinase (AMPK) activity to the regulation of endothelial chemokine production (chapter 6). The potential of insulin to modify the subcellular distribution of eNOS was investigated in chapter 5. Clinical hyperinsulinaemia correlates with attenuated NO-mediated vasodilation, but it …
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Metabolic Regulation and Cryotolerance of In Vitro-Produced Holstein Embryos
… studies was to examine the effects of various metabolic regulators on the viability and cryotolerance of <em>in vitro</em>-produced embryos. Pilot studies revealed that evaluating early (stage 6) versus late (stage 7) blastocysts did not affect the trend seen in results, nor did culturing …
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Metabolic regulation of denitrification in the opportunistic pathogen Pseudomonas aeruginosa
… intrinsic antimicrobial resistance and diverse metabolic physiology. Denitrification allows P. aeruginosa to utilise N-oxides as alternative electron acceptors to enable maintenance of proton motive force and thus the generation of ATP under nutrient- and oxygen-limited scenarios, and may also …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… to increased workload, the heart responds metabolically by increasing its reliance on glucose and structurally by increasing the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth …
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Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
… of transformed cells and suggests a novel metabolic regulation of these processes.
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Metabolic Regulation at Sub-Organelle Length Scales: Inter-Organelle Contacts and Lipid Droplets
Page xii is misnumbered as page xi.
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A mechanistic examination of the metabolic regulation of insulin resistance, sarcopenia, and osteoporosis
Aging is associated with a number of physiological changes, including increased risk of insulin resistance and type 2 diabetes mellitus (T2DM), decreased muscle mass and strength, and decreased bone mass and bone mineral density (BMD). The aim of the studies presented were to investigate 1) the …
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
… PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high rates of glucose, glutamine, leucine and transferrin uptake, and expressed constitutively high levels of CD71, the transferrin receptor, and CD98, the System L amino …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… is a “disease”. Obesity increases the risk of metabolic related diseases, including type 2 diabetes, cardiovascular disease, fatty liver diseases and other human disease like female infertility, mental depression and even certain types of cancer. Obesity, characterized by excessive body weight, …
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