Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Metabolic Endotoxemia"”.
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An investigation of the effects of diet on the gastrointestinal microbiota, inflammation, and metabolic endotoxemia in adults
… need to understand the mechanisms of obesity and metabolic disease and recommend strategies for prevention and treatment has never been greater. Dietary strategies for weight loss and weight maintenance offer the greatest opportunity to provide low-cost, safe, and universally available treatments …
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Characterization of an in vitro exercise model and the effects of a metabolic endotoxemia on skeletal muscle adaptation to electric pulse stimulation
… dismutase 2 (SOD2), substrate metabolism, metabolic enzyme activity, heat stress markers, and pH. To recreate the inflammatory milieu observed in metabolic disease states we treated the myotubes with a low dose of 20 EU lipopolysaccharide (LPS). Following the 24-hour stimulation we observed …
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A Mechanism for the Metabolic and Inflammatory Alterations Associated with Low-dose Endotoxemia
… recent publications have demonstrated severe metabolic alterations after LPS challenge, suppressing lipid oxidation and concurrently up-regulating glucose oxidation. Unfortunately, this switch in metabolism is inefficient for the great energy demands of the host during a systemic microbial …
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Signaling Cross-Talk Regulating the Expression of Arginase 1 in Murine Macrophages
… Gram negative bacteria, and a potent pyrogen. In metabolic endotoxemia, LPS concentration in the blood is slightly elevated, and over the long term this contributes to diverse inflammatory diseases such as atherosclerosis, obesity, and diabetes. LPS promotes the M1 phenotype and suppresses the M2 …
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Diet and exercise modulate the gut microbiome with implications for health and disease
… of insulin sensitivity, inflammation, and metabolic endotoxemia in previously sedentary, lean and obese humans, and how these correlated with already published effects of the exercise intervention on the gut microbiota and microbial metabolites. We found that exercise training reduced …
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Understanding The Role Of Pentraxin 3 In Adipose Tissue Inflammation And Aging
… low-grade inflammation in adipose tissue. Metabolic endotoxemia (elevated circulating lipopolysaccharide [LPS] level) is the inducer of systemic and adipose tissue inflammation and dysfunction, which is developed during obesity and aging. As a soluble pattern recognition receptor, Pentraxin …
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The Effects of Low Dose Endotoxin on Glucose Homeostasis
… elevated blood endotoxin levels, also known as metabolic endotoxemia. In healthy rodents (non-obese and insulin sensitive), there is evidence that blood endotoxin levels fluctuate over the course of the day with elevations in the post-prandial state that return to baseline levels in the …
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Cellular Reprogramming in Skeletal Muscle after Repeated Exposures to Endotoxin
Obesity-related metabolic derangements have been linked to toll-like receptor 4 (TLR4), an innate immune system receptor, due to its role in proinflammatory pathways. Lipopolysaccharide (LPS), a gram-negative bacteria cell wall component, is the ligand for TLR4, and has been shown to be elevated in …
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Novel Mechanisms Underlying the Inflammatory Effects of Leptin and Low Dose Endotoxin
… and low dose endotoxin most recently coined metabolic endotoxemia. Interleukin-Receptor Associated Kinase 1 (IRAK-1) is an intracellular signaling component shown to activate NFκB which leads to the induction of proinflammatory mediators. Deletion of IRAK-1 in mice has beneficial effects in …
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Berries in Prevention of Metabolic Disease – focus on obesity, diabetes and gut microbiota
… is associated with increased risk of several metabolic disorders including insulin resistance, nonalcoholic fatty liver disease and type 2 diabetes. Hence, there is a great need to identify dietary strategies for the prevention of obesity and related diseases. This thesis investigates the …
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Role of IRAK-1 in the Dynamic Regulation of Reactive Oxygen Species
… dependent. Low dose LPS (as seen in chronic metabolic endotoxemia) fails to induce Nrf2 and induces mild and prolonged expression of Nox1. Cells pre-challenged with low dose LPS are primed for more robust expression of ROS following a second LPS challenge. The conclusions and implications …
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Do Probiotics Protect Against the Deleterious Effects of a High-Fat Diet?
… which is associated with low-grade inflammation, metabolic dysregulation and degradation of tight-junction proteins between intestinal cells. Probiotic supplementation is the practice of ingesting live strains of bacteria that are proposed to have a beneficial effect on the host by enriching the …